Acute rhabdomyolysis following administration of high-dose cyclophosphamide: case report

Shima, Etsuko; Hino, Masayuki; Yamane, Takahisa; Aoyama, Yasutaka; Nakamae, Hirohisa; Yamamura, Ryosuke; Makita, Kaori; Sugano, Yukiko; Yasuda, Seidai; Takubo, Takayuki; Ohta, Kensuke; Tatsumi, Noriyuki

doi:10.1007/s00277-001-0399-2

Cited by 21 publications

(13 citation statements)

References 5 publications

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“…4,5 Currently, the use of taxanes following doxorubicin and cyclophosphamide therapy for breast cancer treatment is becoming increasingly common. Taxane preparations are known to induce a wide range of peripheral sensory neuropathy; thus, current chemotherapy protocols predispose women to both myotoxicity and neurotoxicity from these agents.…”

Section: Effects Of Breast Cancer Chemotherapy On Skeletal Musclementioning

confidence: 99%

Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherapy for Breast Cancer

Visovsky

2006

Integr Cancer Ther

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There is evidence to suggest that treatment of breast cancer with chemotherapy can induce metabolic changes in skeletal muscle. Women undergoing treatment for breast cancer with certain chemotherapeutic agents can experience declines in lean body mass and muscle strength and a subsequent increase in body weight. These alterations not only can lead to declines in physical function but also predispose women to weight-related chronic illness. Excess body weight may also play a role in the development or recurrence of breast cancer. There is evidence that physical exercise may improve body composition and enhance muscular endurance, flexibility, and quality of life (QOL) in women with breast cancer. While studies of aerobic, resistance, and combinations of aerobic and resistance exercise for women with breast cancer have been conducted, most studies employed supervised aerobic exercise sessions. Few studies have examined the role of resistance exercise or the combination of resistance and aerobic exercise in maintaining or increasing muscle strength while preserving lean body mass in this population. The relatively small sample sizes and short duration of physical activity interventions in previous studies make it difficult to detect dose responses to exercise training. Physical activity interventions with larger sample sizes and of longer duration are necessary to achieve longterm health outcomes. Physical activity interventions that include the older or more obese women with breast cancer are also needed, as this population may be most at risk of functional decline and the development of chronic illness. Interventions appropriate for women treated for breast cancer who have comorbid disease are also needed. Newer, more intense chemotherapy regimens may induce a differential effect on muscle strength and body composition. However, the role of physical activity during dose-dense chemotherapy protocols has not been established. Keywords: breast cancer; muscle strength; body composition; physical activityThe role of exercise and physical activity in cancer prevention, recovery, and rehabilitation has been the focus of much recent literature. In terms of cancer prevention, physical activity and exercise have been touted as part of a healthy lifestyle that can reduce the incidence of obesity-related chronic illnesses, cancer, and cancer recurrence. However, the mechanism by which physical activity or exercise exerts its effect and the amount of activity necessary remains unknown. There is evidence that physical exercise may improve body composition and enhance muscular endurance, flexibility, and quality of life (QOL) in women with breast cancer. However, most studies of exercise and cancer survivorship have been limited by small sample sizes, similar cancer disease stages, the use of single-modality exercise regimens, and limited duration of follow-up. Investigations of breast cancer disease and treatment side effects on muscle strength and body composition have been limited. The purpose of this article is to examine t...

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Section: Effects Of Breast Cancer Chemotherapy On Skeletal Musclementioning

confidence: 99%

Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherapy for Breast Cancer

Visovsky

2006

Integr Cancer Ther

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“…Rhabdomyolysis can be caused by exercise, crush injuries, muscle ischemia, hypothermia, hyperthermia, and by use of some drugs such as statins commonly used for lipid disorders. Some chemotherapy drugs are known to cause rhabdomyolysis and they include: ifosfamide, CE [5], trabectedin [8], gemcitabine/paclitaxel [9], cytarabine [10], doxorubicin, thioguanine, vincristine [11], mitoxantrone/cyclophosphamide [12], pemetrexed [13], high-dose cyclophosphamide (120 mg/kg) [14], and 5-azacytidine.…”

Section: Discussionmentioning

confidence: 99%

Delayed rhabdomyolysis with paclitaxel, ifosfamide, carboplatin, and etoposide regimen: a case report

Sokolova¹,

Chan²,

Ullah³

et al. 2017

J Med Case Reports

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BackgroundHigh-dose chemotherapy with autologous stem cell rescue is commonly used for the treatment of relapsed germ cell tumors. We report the first case of delayed rhabdomyolysis with paclitaxel, ifosfamide, carboplatin, and etoposide regimen.Case presentationWe report a case of a 21-year-old African-American man diagnosed with relapsed non-seminomatous germ cell tumor who received high-dose chemotherapy with carboplatin and etoposide following TIGER trial arm B off-protocol. His course was complicated by muscle pain and rhabdomyolysis after cycle 4 on day +12 after infusion of autologous stem cells. To the best of our knowledge, this complication has not been reported with this regimen. A differential diagnosis of sepsis and neutropenic fever along with side effects of high-dose chemotherapy were considered, but based on the timing of events, it was concluded that the etiology of rhabdomyolysis is high-dose chemotherapy. Rhabdomyolysis was successfully treated with hydration and did not recur during subsequent cycle 5.ConclusionsDelayed rhabdomyolysis after high-dose chemotherapy with paclitaxel, ifosfamide, carboplatin, and etoposide regimen has not been previously reported and needs to be considered for preventive strategy and prompt diagnosis and treatment to avoid renal complications. Physicians should have a low threshold to check creatine kinase enzymes in patients with unexplained muscle pain or renal insufficiency after high-dose chemotherapy.

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“…In adults, there are several reports of rhabdomyolysis associated with anticancer drugs. The anticancer drugs and their combinations which cause rhabdomyolysis include ET-743 [8], paclitaxel and gemcitabine [9], cytarabine [10], high-dose ifosfamide, carboplatin and etoposide [11], stem cell transplantation conditioning using thiotepa and melphalan [12], doxorubicin, cytarabine, thioguanine and vincristine [13], mitoxantrone and cyclophosphamide [14], pemetrexed [15], high-dose cyclophosphamide [16], vincristine, cytarabine and adriablastin [17], and 5-azacytidine [18] (table 1). …”

Section: Discussionmentioning

confidence: 99%

“…and anthracenediones (mitoxantrone, etc.) induce cardiac muscle damage, although skeletal muscle damage is uncommon [14, 16]. Anthracyclines and anthracenediones induce the generation of oxygen free radicals leading to cardiac muscle injury, although it is unclear why a similar phenomenon does not occur in skeletal muscle [14].…”

Section: Discussionmentioning

confidence: 99%

Severe Acute Rhabdomyolysis Induced by Multi-Agent Chemotherapy for Alveolar Rhabdomyosarcoma in a 15-Year-Old Female: A Case Report

Matsuzaki

Koga²,

Suminoe

et al. 2013

Case Rep Oncol

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This is the first paper to report the association of cancer chemotherapy with rhabdomyolysis in children. A previously healthy, 15-year-old Japanese female was diagnosed as having alveolar rhabdomyosarcoma. She received the first cycle of multi-agent chemotherapy without any adverse effects. However, she developed severe acute rhabdomyolysis shortly after the second cycle of multi-agent chemotherapy, which consisted of etoposide, ifosfamide, actinomycin-D and vincristine. Her condition deteriorated rapidly and she was treated with mechanical ventilation and fluid replacement. After further evaluation, anticancer drugs were thought to be responsible for the rhabdomyolysis.

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Acute rhabdomyolysis following administration of high-dose cyclophosphamide: case report

Cited by 21 publications

References 5 publications

Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherapy for Breast Cancer

Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherapy for Breast Cancer

Delayed rhabdomyolysis with paclitaxel, ifosfamide, carboplatin, and etoposide regimen: a case report

Severe Acute Rhabdomyolysis Induced by Multi-Agent Chemotherapy for Alveolar Rhabdomyosarcoma in a 15-Year-Old Female: A Case Report

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