Acute rhabdomyolysis during treatment with amisulpride and metformin

Ursini, Francesco; Succurro, Elena; Grembiale, Alessandro; Arturi, Franco

doi:10.1007/s00228-009-0773-x

Cited by 10 publications

(7 citation statements)

References 10 publications

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“…There is only one previous report in the literature that describes a CK elevation in a patient receiving amisulpride; however, this report was inconclusive as the patient had also been taking met formin, which might have also contributed to the CK elevation, and no further elevation of CK followed rechallenge [3]. In our first case, CK elevation was observed under a combination of clo zapine and amisulpride.…”

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confidence: 55%

Reversible Amisulpride-induced Elevation of Creatine Kinase (CK): A Case Series from the German AMSP Pharmacovigilance Project

et al. 2015

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The elevation of creatine kinase (CK) levels without neuroleptic malignant syndrome has been reported for several antipsychotics. We present here 4 cases with CK elevation induced by amisulpride, which have been registered for the German pharmacovigilance project, Arzneimittelsicherheit in der Psychiatrie (AMSP). The magnitude of the CK elevation ranged between 1, 498 IU/L and 21,018 IU/L. All 4 patients reported myalgia. In each case CK returned to normal after amisulpride discontinuation. In the fourth case, fluids were administered intravenously in order to prevent acute renal failure. None of the cases showed deterioration of renal function. Finally, we present recommendations for clinical practice.

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confidence: 55%

Reversible Amisulpride-induced Elevation of Creatine Kinase (CK): A Case Series from the German AMSP Pharmacovigilance Project

et al. 2015

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“…Although there are cases of metformin-induced rhabdomyolysis, they are typically associated with overdose. [ 34 , 35 ] Interestingly, atorvastatin is the second most prescribed statin (24.4–36%), [ 36 , 37 ] and the incidence of atorvastatin-induced myopathy is approximately 14.9%. [ 38 ] However, the patient had discontinued atorvastatin for 1 month before the onset of rhabdomyolysis, and we are not aware of any delayed cases of atorvastatin-induced rhabdomyolysis.…”

Section: Discussionmentioning

confidence: 99%

A Klebsiella pneumoniae liver abscess presenting with myasthenia and tea-colored urine

Deng

Jia²,

Li³

et al. 2017

Medicine

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“…One case described the association of metformin to rhabdomyolysis in the context of a combined overdose of metformin, ramipril, and alcohol [14]. Another described its association during the concomitant use with an antipsychotic drug [15]. To our knowledge, there have been no reports in the literature describing a direct link between metformin and rhabdomyolysis, although there have been case reports connecting other antidiabetic agents to rhabdomyolysis, such as sitagliptin, rosiglitazone, pioglitazone, and troglitazone [16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

McArdle disease: a “pediatric” disorder presenting in an adult with acute kidney injury

Zhao

Soni

et al. 2017

CEN Case Rep

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Rhabdomyolysis is characterized by the acute breakdown of skeletal muscle, resulting in the release of muscle cell contents, subsequent myoglobinuria, and in severe cases, acute renal failure. A number of etiologies have been identified in acute rhabdomyolysis, in which drugs and trauma account for the majority of cases. One etiological category that is commonly overlooked in the adult population is an underlying genetic defect. This may be challenging to diagnose due to its rarity in the adult demographic and the marked heterogeneity, often requiring a high level of clinical suspicion before investigation is pursued. Once diagnosed, however, appropriate steps can be taken to reduce future episodes of rhabdomyolysis, further renal injury, and other systemic complications. Here, we report a case of an adult patient presenting with acute rhabdomyolysis secondary to McArdle disease, a genetic disease causing defective glycogenolysis. The case highlights the importance of recognizing the potential of undiagnosed ''pediatric'' disorders in adulthood and particularly for underlying genetic causes of rhabdomyolysis.

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Acute rhabdomyolysis during treatment with amisulpride and metformin

Abstract: . Acute rhabdomyolysis during treatment with amisulpride and metformin.

Cited by 10 publications

References 10 publications

Reversible Amisulpride-induced Elevation of Creatine Kinase (CK): A Case Series from the German AMSP Pharmacovigilance Project

Reversible Amisulpride-induced Elevation of Creatine Kinase (CK): A Case Series from the German AMSP Pharmacovigilance Project

A Klebsiella pneumoniae liver abscess presenting with myasthenia and tea-colored urine

McArdle disease: a “pediatric” disorder presenting in an adult with acute kidney injury

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