Acute rhabdomyolysis associated with troglitazone.

Pioglitazone-Induced Acute Rhabdomyolysis

“…In our review of the literature and according to data from a MEDLINE search, previous case reports of elevated serum creatinine phosphokinase, myopathy, or rhabdomyolysis have been identified in patients taking rosiglitazone or troglitazone (2,3). Potential risk factors identified in these cases included concomitant therapy with fibrate, alcohol abuse, and asymptomatic mild creatinine phosphokinase elevation prior to initiating therapy.…”

Safety of olmesartan in a patient with telmisartan‐induced myotoxicity: a case report

“…Increased activity of PPAR-γ has been associated with myalgia and rhabdomyolysis. Drugs that primarily modulate PPAR-γ activity, such as pioglitazone, troglitazone and rosiglitazone, are associated with similar adverse events; thus, the off-target action of telmisartan on PPAR-γ activity could be one of the reasons for myotoxicity in our case [10][11][12]. Lipophilicity is an important factor that enables drugs to cross cell membranes, and lipophilic drugs have greater affinity for the PPAR-γ receptor.…”

McArdle disease: a “pediatric” disorder presenting in an adult with acute kidney injury

“…Another described its association during the concomitant use with an antipsychotic drug [15]. To our knowledge, there have been no reports in the literature describing a direct link between metformin and rhabdomyolysis, although there have been case reports connecting other antidiabetic agents to rhabdomyolysis, such as sitagliptin, rosiglitazone, pioglitazone, and troglitazone [16][17][18][19]. In all of the cases, the described association has occurred in patients who were also taking other medications in addition to the antidiabetic agent of interest, including ones notoriously known to cause rhabdomyolysis, such as statins and fibrates.…”