Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

Majdinasab, Nastaran; Motl, Robert W.; Mokhtarzade, Motahare; Zimmer, Philipp; Ranjbar, R; Keytsman, Charly; Cullen, Tom; Negaresh, Raoof; Baker, Julien S.

doi:10.1016/j.ctcp.2018.03.004

Cited by 21 publications

(28 citation statements)

References 33 publications

(70 reference statements)

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“…This inflammatory hypothesis is supported by findings from clinical studies and animal experiments showing that anti-inflammatory agents attenuated neuronal dysfunction in AD [27,28]. Physical exercise confers broad anti-inflammatory effects in many neurodegenerative diseases, probably by affecting the secretion of inflammatory cytokines/adipokines via the muscle-adipose crosstalk [29,30]. It has been shown that exercise can improve the immune status of the brain, either by inhibiting the production of pro-inflammatory factors such as IL-1β [31], or by promoting the synthesis of anti-inflammatory factors such as IL-10 [32].…”

Section: Discussionmentioning

confidence: 83%

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice

Liu

Chu

Yan

et al. 2020

J Neuroinflammation

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Background: Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the elderly. However, the neuroprotective effects of resistance training in cognitive impairment are not well characterized. Methods: We evaluated whether short-term resistant training could improve cognitive function and pathological changes in mice with pre-existing cognitive impairment. Nine-month-old 3xTg mouse underwent a resistance training protocol of climbing up a 1-m ladder with a progressively heavier weight loading. Results: Compared with sedentary counterparts, resistance training improved cognitive performance and reduced neuropathological and neuroinflammatory changes in the frontal cortex and hippocampus of mice. In line with these results, inhibition of pro-inflammatory intracellular pathways was also demonstrated. Conclusions: Short-term resistance training improved cognitive function in 3xTg mice, and conferred beneficial effects on neuroinflammation, amyloid and tau pathology, as well as synaptic plasticity. Resistance training may represent an alternative exercise strategy for delaying disease progression in Alzheimer's disease.

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Section: Discussionmentioning

confidence: 83%

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice

Liu

Chu

Yan

et al. 2020

J Neuroinflammation

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“…Weight gain is associated with releasing leptin from adipose tissue which stimulates proinflammatory cytokines produced from T helper 1 cells such as TNFα (Majdinasab et al, 2018;Mokhtarzade et al, 2017). In addition, there are more macrophages, T cells, and inflammatory molecules connected with more subcutaneous adipose tissues (Esser et al, 2014).…”

Section: Exercise-related Neurotrophic Factors Modulationmentioning

confidence: 99%

“…

Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis Ranjbar, R. (2018). Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis.

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confidence: 95%

Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis

et al. 2018

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Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60-70% peak power. Resting blood concentrations of s100 calcium-binding protein B (s100b) and neuron-specific enolase as BBB permeability markers, neurotrophic factors and cytokines (Interleukin-10 and tumor necrosis factor alpha) were evaluated before and after the intervention. There were significant weight, training, and interaction effects on brain-derived neurotrophic factor and platelet-derived growth factor; however, ciliary neurotrophic factor and nerve growth factor did not demonstrate any effect. Brain-derived neurotrophic factor and platelet-derived growth factor were significantly increased from pre-post in normal weight exercise. Significant weight, training, and interaction effects were found for s100b. In detail, s100b was significantly increased from pre-post in normal weight exercise. In contrast, neuron-specific enolase and cytokines did not demonstrate any effect. Generally, Exercise training may alter markers of BBB permeability and neurotrophic factor status in normal weight persons with multiple sclerosis; however, overweight participants may be more resistant to these effects of exercise.

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“…Multiple sclerosis (MS) is a common neurological disease of the central nervous system (CNS) that occurs when lymphocytes cross the blood–brain barrier (BBB) and initiate axonal demyelinating processes . MS is further characterized by the presence of plaques in the brain that are detectable through magnetic resonance imaging (MRI), disturbances in neurotrophic factors, BBB dysfunction and accelerated whole‐brain atrophy .…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status: a systematic review of intervention studies

Negaresh

Motl

Zimmer

et al. 2019

Euro J of Neurology

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Background and purpose Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS) that can be tracked through biomarkers of disease status. We investigated the effects of exercise on MS biomarkers associated with CNS status including imaging, blood–brain barrier (BBB) function and neurotrophic factors. Methods We conducted open‐dated searches of Scopus, Medline, EMBASE and the Cochrane Library. We included studies written in English describing interventions of exercise that measured one or more of the biomarkers associated with MS published up to October 2018. Results We located a total of 3012 citations through searches in electronic databases. Of these, 16 studies were eligible for review; six studies focused on magnetic resonance imaging (MRI) markers, nine studies focused on neurotrophic factors and three studies focused on BBB function markers. It is of note that two studies included both neurotrophic factor and BBB function markers and are therefore included across categories of biomarkers in this review. The existing evidence from MRI studies confirmed that exercise training can improve CNS integrity and function. There is evidence of a positive effect of exercise training on modulation of BBB permeability markers and brain‐derived neurotrophic factor. Conclusions Exercise successfully improves MRI outcomes and peripheral biomarkers (i.e. brain‐derived neurotrophic factor) in people with MS. This suggests that exercise can be recommended as an adjuvant therapy for MS treatment. This conclusion is tempered by some methodological limitations including small sample sizes and high drop‐out rates in the reviewed studies.

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Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

Abstract: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.

Cited by 21 publications

References 33 publications

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice

Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis

Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status: a systematic review of intervention studies

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