Acute Respiratory Infection and Use of Nonsteroidal Anti-Inflammatory Drugs on Risk of Acute Myocardial Infarction: A Nationwide Case-Crossover Study

Abstract

Nonsteroidal anti-inflammatory drugs use during ARI episodes, especially parenteral NSAIDs, was associated with a further increased risk of AMI.

Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland

“…The finding that other respiratory viruses for which vaccines are not available also act as cardiovascular triggers merits further exploration. It potentially strengthens the case for considering antithrombotic strategies during acute respiratory tract infections for vulnerable groups, especially as recent evidence points to a dual effect of acute respiratory tract infections and symptomatic nonsteroidal anti-inflammatory drug treatment on cardiovascular risk [ 29 ]. Future research should focus on informing development and delivery of stratified interventions to reduce vascular risk associated with a range of respiratory organisms.…”

Non-steroidal anti-inflammatory drugs and covid-19

“…In observational studies, long term use of NSAIDs such as ibuprofen, naproxen, and diclofenac has been associated with higher rates of cardiovascular outcomes such as myocardial infarction, heart failure, and stroke2—albeit with ongoing debate about residual confounding 3. Acute respiratory tract infections are already associated with increased risk of stroke and myocardial infarction, and short term use of NSAIDs during the illness is associated with further increases in risk 45. NSAIDs cause nephrotoxicity,67 which is more likely among the patient groups most likely to be seriously affected by covid-19 and is exacerbated by fever and dehydration.…”

The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19

“…However, since the use of both NSAIDs and acetaminophen could be associated with a masking of the symptoms during COVID-19, and thus to a diagnostic delay and a prolonged illness, complications may be more common when NSAIDs are used-both respiratory and cardiovascular [66]. In patients with acute respiratory infection, NSAIDs have been widely used and evidence suggests that in these circumstances NSAIDs are associated with an increased risk of stroke and myocardial infarction [67][68][69]. Moreover, large randomized trials support that NSAIDs may cause more prolonged illness or complications when taken during respiratory tract infections [70,71].…”