Acute Respiratory Distress Syndrome Associated with Tumour Lysis Syndrome in Leukemia

Bell, Chaim M.; Stewart, Thomas E.

doi:10.1155/1997/947060

Cited by 3 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is characterized by electrolyte abnormalities (hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia) leading to acute kidney injury, cardiac arrhythmias and potentially multiorgan failure [19]. Life-threatening acute respiratory failure and ARDS associated with tumor lysis syndrome have been described [21,22].…”

Section: Non-infectious: Treatment-related-tumor Lysis Syndromementioning

confidence: 99%

Acute Respiratory Failure in the Oncologic Patient: New Era, New Issues

Ferreyro

Munshi

2019

Annual Update in Intensive Care and Emergency Medicine 2019

View full text Add to dashboard Cite

Section: Non-infectious: Treatment-related-tumor Lysis Syndromementioning

confidence: 99%

Acute Respiratory Failure in the Oncologic Patient: New Era, New Issues

Ferreyro

Munshi

2019

Annual Update in Intensive Care and Emergency Medicine 2019

View full text Add to dashboard Cite

“…20 Lysis of leukemic myeloid cells may result in diffuse alveolar damage. [21][22][23] The chest radiograph may be normal, show a bilateral reticular pattern with septal lines, or bilateral airspace consolidation. 24,25 These findings are similar to those of interstitial and airspace pulmonary edema.…”

Section: Leukemic Pulmonary Infiltratesmentioning

confidence: 99%

Myeloid Leukemias and Lung Involvement

Koh

Colby

Müller

2005

Seminars in Respiratory and Critical Care Medicine

View full text Add to dashboard Cite

Myeloid leukemias are clonal malignancies characterized by the presence of increased numbers of immature myeloid cells in the marrow and peripheral blood. Pulmonary involvement by myeloid leukemia is relatively uncommon and seen mainly in patients with severe disease. The most common form of pulmonary involvement consists of leukemic infiltration along the lymphatics in the peribronchovascular, septal, and pleural interstitial tissue. Less common manifestations include myeloid sarcoma, leukostasis, leukemic cell lysis pneumopathy, and hyperleukocytic reaction. The radiological manifestations of pulmonary leukemic cell infiltration and leukostasis consist mainly of bilateral thickening of the peribronchovascular interstitium and interlobular septa, a pattern that resembles that of interstitial pulmonary edema. The radiological manifestations of leukemic cell lysis pneumopathy and hyperleukocytic reaction consist of symmetric bilateral areas of consolidation. This manuscript reviews the histological and radiological intrathoracic manifestations of myelogenous leukemias.

show abstract

Spontaneous Acute Tumor Lysis Syndrome in Acute Myeloid Leukemia? A Single Case Report with Discussion of the Literature

Loth

Brandwein

1998

Leukemia & Lymphoma

View full text Add to dashboard Cite

Acute tumor lysis syndrome (ATLS), a condition which results from a rapid destruction of tumor cells with massive release of cellular breakdown products, has been well described following the treatment of various malignancies. However, only a handful of cases of spontaneous ATLS have been reported in the literature. We describe the first reported case of spontaneous ATLS in acute myeloid leukemia (AML). A previously healthy 63 year old woman presented with a two month history of fatigue and a one week history of easy bruising. On admission she had oliguric acute renal failure, with marked elevation in serum uric acid and phosphate. A bone marrow biopsy showed AML M7 with fibrosis. The renal failure resolved with supportive care and institution of allopurinol therapy. Following this, AML induction chemotherapy resulted in complete remission. Her biochemical and clinical course were very similar to the classical ATLS seen in patients after chemotherapy. Therefore, this case represents a rare instance of acute renal failure from spontaneous ATLS, and in our opinion the first reported occurrence of spontaneous ATLS associated with AML.

show abstract

Acute Respiratory Distress Syndrome Associated with Tumour Lysis Syndrome in Leukemia

Cited by 3 publications

References 13 publications

Acute Respiratory Failure in the Oncologic Patient: New Era, New Issues

Acute Respiratory Failure in the Oncologic Patient: New Era, New Issues

Myeloid Leukemias and Lung Involvement

Spontaneous Acute Tumor Lysis Syndrome in Acute Myeloid Leukemia? A Single Case Report with Discussion of the Literature

Contact Info

Product

Resources

About