Acute respiratory disorder, rhinoconjunctivitis and fever associated with the pyrolysis of polyurethane derived from diphenylmethane diisocyanate.

Littorin, Margareta; Truedsson, Lennart; Welinder, Hans; Skarping, Gunnar; Mårtensson, Ulla; Sjöholm, A G

doi:10.5271/sjweh.1405

Cited by 33 publications

(16 citation statements)

References 26 publications

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“…The authors indicated these findings support to their patients autoimmune disposition. However, although detailed examinations they also stated that the mechanism behind the isocyanate-related disease was still obscure [23]. In our patients we did not find additional disease or laboratory findings which can support to an autoimmune disposition.…”

Section: Discussionmentioning

confidence: 47%

Untitled

2014

Glob Dermatol

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Lichen Planus (LP) is a chronic mucocutaneous disease with several variants defined by the configuration of lesions, the morphological appearance, and the site of involvement. Although exact cause of LP is not known, it is thought that it is most likely an immunologically mediated reaction especially a cell-mediated immune response of unknown origin. Typical lesion is seen as a pruritic, papular eruption characterized by its violaceous color; polygonal shape; and, sometimes, fine scale. The size can vary from 1 mm to greater than 1 cm in diameter . It is most commonly found on the flexor surfaces of the upper extremities, on the genitalia, and on the mucous membranes. The clinical presentation of the disease has several forms: actinic, annular, atrophic, erosive, follicular, hypertrophic, linear, pigmented, vesicular/ bullous and eruptive/exanthematous. "Exanthematous" or "eruptive" LP is a rare variant of the disease. Herein we report a 15 year-old boy, and a 32-year old man with a 1.5 and 3-month history respectively, of acute, episodic and eruptive mucocutaneous LP after a toluene exposure. To the best of our knowledge, our patients are the first cases of exanthematous mucocutaneous lichen planus that were caused by toluene exposure.

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Section: Discussionmentioning

confidence: 47%

Untitled

2014

Glob Dermatol

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“…All inhalation exposure was below the existing occupational ACGIH exposure standards of 51 µg/m 3 . Low exposure was also observed by other researchers [6,12,13]. There are various sampling methods, all of which have some limitations in assessing air concentration of MDI [14].…”

Section: Discussionmentioning

confidence: 75%

“…There are various sampling methods, all of which have some limitations in assessing air concentration of MDI [14]. Sampling of isocyanates also poses many challenges due to their reactivity and varying physical states in air [13,14,15]. It has been suggested that impingers should be favored for sampling [15]; therefore, in the present study this method was selected to be used for measuring MDI, followed by evaluating its adverse effects on exposed workers.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Workers’ Exposure to Methylene Diphenyl Diisocyanate (MDI) in an Automobile Manufacturing Company, Iran

Kakooei

Shahtaheri

Karbasi

2006

International Journal of Occupational Safety and Ergonomics

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“…As albumin conjugates of MDI have been shown to produce a weak immediate type respiratory hypersensitivity in previously sensitized guinea pigs [38], we may predict similar responses to albumin conjugates of NDI. Raised levels of IgE antibodies to human serum albumin-MDI conjugates have been observed in both guinea pigs and exposed workers [43]. Whether the NDI-adducts detected in the workers at issue play a part in the irritation or sensitization responses to NDI is still not certain.…”

Section: Discussionmentioning

confidence: 99%

Albumin adducts and urinary metabolites resulting from occupational exposure to 1,5-naphthalene diisocyanate

Sepai

Sabbioni

2017

Int J Occup Med Environ Health

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Objectives: 1,5-Naphthalene diisocyanate (NDI) is used in the plastic industry as a curing agent. 1,5-Naphthalene diisocyanate is classified as a sensitizing agent. The objective of this study has been to develop biomonitoring methods for the evaluation of exposure to NDI. Material and Methods: We obtained blood and urine samples from a group of 20 male workers exposed to NDI. The workers answered a questionnaire about their exposure history, job description, the number of years with the company and the time spent working with NDI over the 10 days of the study. Total plasma, albumin, and urine were analyzed for the presence of 1,5-naphthalenediamine (NDA) after acid hydrolysis using gas chromatography-mass spectrometry (GC-MS). Results: 1,5-Naphthalenediamine was found in about 60% of the samples obtained from the workers. 1,5-Naphthalenediamine was obtained after acid hydrolysis of plasma, albumin, and urine at levels up to 1.5 pmol NDA/mg of plasma proteins, 1.15 pmol NDA/mg of albumin, and 55.3 pmol NDA/ml of urine, respectively. Conclusions: 1,5-Naphthalenediamine found in urine correlates best with the plasma levels (r = 0.91, p < 0.01). The albumin-adduct levels did not correlate with the NDI-specific immunoglobulin E (IgE) or total IgE present in the workers. The adduct and metabolite levels correlate with the air levels of NDI. Int J Occup Med Environ Health 2017;30(4):579-591

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Acute respiratory disorder, rhinoconjunctivitis and fever associated with the pyrolysis of polyurethane derived from diphenylmethane diisocyanate.

Cited by 33 publications

References 26 publications

Untitled

Untitled

Evaluation of Workers’ Exposure to Methylene Diphenyl Diisocyanate (MDI) in an Automobile Manufacturing Company, Iran

Albumin adducts and urinary metabolites resulting from occupational exposure to 1,5-naphthalene diisocyanate

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