Acute Renal Failure, Microangiopathic Haemolytic Anemia, and Secondary Oxalosis in a Young Female Patient

Stępień, Karolina M.; Prinsloo, Peter; Hitch, Tony; McCulloch, Tom; Sims, Rebecca

doi:10.4061/2011/679160

Cited by 8 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These side effects have been generally associated with using high doses of vitamin C. However, “high dose” is not clearly defined and is arbitrarily considered a dose of more than 10 g/day in adults. 24 Although most of the cases in the present meta-summary had taken “high dose” of intravenous vitamin C, 8 , 11 , 15 – 17 we also found cases reported after prolonged low-dose oral vitamin C, 14 and even after low-dose intravenous therapy. 9 , 10 , 18 …”

Section: Discussionsupporting

confidence: 47%

Vitamin C-induced Hemolysis: Meta-summary and Review of Literature

Juneja¹,

Nasa²,

Jain³

2022

Indian Journal of Critical Care Medicine

View full text Add to dashboard Cite

Vitamin C is increasingly being used, and even high doses are considered safe. However, complications including hemolysis have been reported. We performed a systematic search from PubMed, Science Direct, and Google Scholar databases from January 1975 till July 31, 2021. Search terms used were “Vitamin C” OR “ascorbic acid” AND “haemolysis” OR “haemolytic anaemia.” Data regarding patient's demographics, outcomes and dose, duration, and form of vitamin C were extracted. Fourteen case reports matched the selected criteria, with age ranging from 3 weeks to 75 years with 78.6% being males. About 71.4% were diagnosed to have glucose-6-phosphate dehydrogenase (G6PD) deficiency but previous hemolysis was reported in only two patients, and 57.1% were prescribed vitamin C for nutritional supplementation. The dose ranged from 1 to 200 g/day with 57.1% receiving intravenous formulations. Half of these patients developed other complications including acute kidney injury (AKI), disseminated intravascular coagulation, oxalosis, and methemoglobinemia. About 78.6% developed complications within 3 days of starting vitamin C and only one death was reported. Vitamin C is generally a safe drug but it should be prescribed with caution and only when benefits outweigh the risks. Physicians should be aware of potential complications like severe hemolysis and AKI, especially when using high doses and in G6PD deficiency. How to cite this article Juneja D, Jain R, Nasa P. Vitamin C-induced Hemolysis: Meta-summary and Review of Literature. Indian J Crit Care Med 2022;26(2):224–227.

show abstract

Section: Discussionsupporting

confidence: 47%

Vitamin C-induced Hemolysis: Meta-summary and Review of Literature

Juneja¹,

Nasa²,

Jain³

2022

Indian Journal of Critical Care Medicine

View full text Add to dashboard Cite

show abstract

“…If these measures are unsuccessful, dialysis may be required. 35 Organ transplantation is a treatment option when there are concerns for systemic oxalosis. 3,37 This report presents the case of acute kidney failure from secondary oxalosis due to multiple risk factors, including excessive vitamin C ingestion, prior gastric bypass, and CKD.…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Disease Due to Excessive Vitamin C Ingestion and Remote Roux-en-Y Gastric Bypass Surgery Superimposed on CKD

Sunkara¹,

Pelkowski²,

Dreyfus

et al. 2015

American Journal of Kidney Diseases

View full text Add to dashboard Cite

“…Acute oxalate nephropathy is characterized by AKI and often progresses to ESKD. In such event, renal replacement therapy may be required and if concern for primary hyperoxaluria is present, combined liver and kidney transplantations may need to be considered [ 5 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

A hidden cause of oxalate nephropathy: a case report

2021

View full text Add to dashboard Cite

Background Oxalate nephropathy is a rare disorder that can result in acute kidney injury (AKI) and progresses to end-stage kidney disease (ESKD). The causes can be either primary or secondary. Primary hyperoxaluria includes a group of hereditary disorders with enzymatic defects in the glyoxylate pathway, resulting in decreased oxalate metabolism. Secondary hyperoxaluria, often overlooked can result from increased intestinal absorption, nutritional deficiencies, decreased fluid intake, impaired excretion, and increased dietary consumption of oxalate. Case presentation We present a Caucasian case of acute oxalate induced nephropathy associated with consumption of large quantities of green vegetables in a patient with chronic kidney disease (CKD). Imaging study showed no evidence of kidney stone, but a kidney biopsy revealed acute tubular injury, tubular atrophy, interstitial fibrosis, and dense tubular deposition of calcium oxalate crystals. Upon further questioning the patient, we learned that in the months prior to presentation, he had very significantly increased his consumption of green vegetables. Because of no clinical improvement, the patient was initiated and maintained on hemodialysis. Conclusion This report illustrates a case of acute oxalate nephropathy in the setting of very high dietary consumption of oxalate-rich foods in a patient with advanced CKD. Special attention should be given to the secondary causes of hyperoxaluria in patients with predisposing conditions such as CKD.

show abstract

Acute Renal Failure, Microangiopathic Haemolytic Anemia, and Secondary Oxalosis in a Young Female Patient

Cited by 8 publications

References 18 publications

Vitamin C-induced Hemolysis: Meta-summary and Review of Literature

Vitamin C-induced Hemolysis: Meta-summary and Review of Literature

Acute Kidney Disease Due to Excessive Vitamin C Ingestion and Remote Roux-en-Y Gastric Bypass Surgery Superimposed on CKD

A hidden cause of oxalate nephropathy: a case report

Contact Info

Product

Resources

About