Acute renal failure in premature neonates

Doronjski, Aleksandra; Stojanović, Vesna; Spasojević, Slobodan; Kovacevic, Branka; Pavlovic, Vesna; Nikolić, Marko; Savic, Radojica

doi:10.2298/vsp0911863d

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…No nonoliguric AKI was associated with less morbidity and mortality than the oliguric AKI, probably because of the lesser degree and shorter duration of azotaemia. [20][21][22][23] In 39/50 (78.5%) of the patients prerenal azotaemia was registered as a result of the inappropriate renal perfusion. This finding cor-relates with the data presented in the studies of Ottonello et al and Gopal et al [24][25] Namely, Ottonello found prerenal azotemia in 85% of patients with neonatal AKI, while Gopal in 80% of patients.…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury in Newborns

Timovska

Cekovska

Tosheska-Trajkovska

2015

Prilozi

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Objective: Acute kidney injury is common condition in the neonatal intensive care unit and it is associated with poor outcome. The incidence of neonatal AKI is the highest one followed by adults and children, depending on different factors such as the gestational age, birth weight, contributing conditions and the facilities of the neonatal intensive care unit. The aim of the study was to determine the incidence, risk factors and the outcome of the neonatal acute kidney injury. Subjects and Methods: This was a clinical, prospective study that was performed in a referent NICU at the University Children's Hospital in Skopje. All neonates admitted from January 2012 to December 20014 with documented acute kidney injury were included. The medical data records of the admitted neonates with AKI were analyzed. The material was statistically processed using methods of the descriptive statistics. Results: During the study period 770 newborn infants were admitted to the NICU and 50 (6.5%) infants developed acute kidney injury. The male to female ratio was 2.1:1. Most of the neonates involved in the study were neonates born at term (62%). Oliguric AKI was found in 28 cases (56%) and no oliguric in 22 cases (44%). The prevalence of prerenal, renal and post renal AKI were 78.5%, 19.5% and 2.0% respectively. Perinatal asphyxia was the most common predisposing factor for AKI and was evaluated in 38% of the cases with predominance of term infants and male. The mortality rate was 32% and was significantly higher in the group of patients with congenital heart diseases. Conclusion: AKI is a life threatening condition with still high mortality rate. Early recognition of the risk factors and the rapid effective treatment of the contributing conditions will reduce AKI in the neonatal period.

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Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury in Newborns

Timovska

Cekovska

Tosheska-Trajkovska

2015

Prilozi

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“…The predisposing factors associated with neonatal kidney injury are certain clinical conditions such as perinatal asphyxia, neonatal sepsis, prematurity, meconium aspiration syndrome, congenital heart diseases, therapeutic interventions and other nephrotoxic drugs. Appropriate treatment of associated comorbidities and reduction in the use of potential nephrotoxic drugs reduce the risk of AKI in neonates in NICU ( 10 - 14 ).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Gelatinase-Associated Lipocalin as an Early Biomarker of Acute Kidney Injury in Newborns

Naunova-Timovska

2020

ACC

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The aim of the study was to determine the incidence, risk factors and efficiency of the neutrophil gelatinase-associated lipocalin (NGAL) biomarker in early diagnosis of acute kidney injury (AKI) in newborns. The study was designed as a prospective, clinical, epidemiological investigation conducted in the period of three years, which included 50 newborns with AKI hospitalized in the Neonatal Intensive Care Unit, University Children's Hospital in Skopje. The estimated prevalence of AKI was 6.4%, while the prevalence according to RIFLE classification was 8.7%. Perinatal asphyxia was a common predisposing factor associated to kidney injury. The mortality rate was 32% and was significantly higher in the group of newborns with congenital heart diseases. There was a significant difference between NGAL values and creatinine values on the day of admission. There was a significant difference in NGAL values between newborns with AKI and lethal outcome and newborns without lethal outcome (p<0.001). In conclusion, AKI is a life-threatening condition. It is an independent contributor to mortality. Urinary NGAL is an early predictive biomarker of AKI in critically ill newborns.

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“…[ 18 ] The common conditions contributing to kidney injury in the neonatal period include neonatal sepsis, birth asphyxia, respiratory distress syndrome, dehydration, heart failure, and urologic anomalies; the first two being the most common causes. [ 19 20 21 22 23 24 ] Even though birth asphyxia is one of the most common causes of renal failure in the neonatal population, the actual incidence is not well known. This is because, we usually suspect renal failure when a patient develops oliguria, and up to 33% cases of AKI in neonates are nonoliguric.…”

Section: Discussionmentioning

confidence: 99%

Acute kidney injury in birth asphyxiated patients: A cross sectional study at Bahawal Victoria Hospital

Tounsa,

Hussain,

Hussain

et al. 2024

Lung India

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Background: The presence of perinatal asphyxia and its severity appear to correlate with increasing incidence of Acute kidney injury (AKI). The objective of this study is to determine the frequency of AKI and its outcome in birth asphyxia. Methods: This cross-sectional study was carried out in the Department of Pediatric Medicine from March 2019 to September 2019. A total of 111 newborns with birth asphyxia of gestational age 37–41 weeks were included. Neonates born to mothers having hypertension and diabetes mellitus, patients with congenital kidney anomalies like polycystic kidney disease and renal agenesis, and mothers taking nephrotoxic drugs or any other known cause of AKI like hypovolemic shock were excluded. Urine output (UOP) and final outcome of the patient were also noted. AKI was noted. Results: The mean gestational age was 38.29 ± 1.07 weeks. The mean weight of neonates was 3.08 ± 0.31 kg. The frequency of AKI in birth asphyxia was 20 (18.02%) neonates. Complete recovery in AKI patients was seen in 07 (35.0%) and death in 13 (65.0%) patients. Conclusion: This study has shown that the frequency of AKI in birth asphyxia was found in 18.02% neonates with complete recovery seen in 35.0% and death in 65.0% patients.

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Acute renal failure in premature neonates

Abstract: Acute renal failure frequently occurs in population of premature neonates and requires meticulous fluid and electrolyte balance, especially in the case of low birth weight and extreme immaturity.

Cited by 6 publications

References 20 publications

Acute Kidney Injury in Newborns

Acute Kidney Injury in Newborns

Neutrophil Gelatinase-Associated Lipocalin as an Early Biomarker of Acute Kidney Injury in Newborns

Acute kidney injury in birth asphyxiated patients: A cross sectional study at Bahawal Victoria Hospital

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