Acute Renal Failure in Marathon Runners

MacSearraigh, E. T.; Kallmeyer, J.C.; Schiff, Harold B.

doi:10.1159/000181723

Cited by 42 publications

(20 citation statements)

References 6 publications

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“…It is known from marathon running that the eccentric loads of long-term running may cause acute renal failure through dehydration, hemolysis, and rhabdomyolysis (Irving et al 1990;MacSearraigh et al 1979). In case of severe muscle damage, creatine kinase and myoglobin from the skeletal muscle cells will be released into the blood, and myoglobinuria (Uberoi et al 1991) can result.…”

Section: Dehydration and Impaired Renal Function Due To Skeletal Muscmentioning

confidence: 99%

The Effects of Running 1,200 km Within 17 Days on Body Composition in a Female Ultrarunner—Deutschlandlauf 2007

Knechtle¹,

Duff²,

Schulze³

et al. 2008

Research in Sports Medicine

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We describe the changes of body composition in the female overall winner of the Deutschlandlauf 2007 over 17 stages from the northeast to the southwest of Germany with average daily running stages of 70.9 km to cover the total distance of 1,200 km. Determined by bioelectrical impedance analysis, body mass (BM) increased, percent body fat (% BF) decreased, and percent body water as well as lean body mass (LBM) increased. Skeletal muscle mass and % BF as determined by an anthropometric method showed no changes. This data show, that this female runner achieved an excellent performance and that it is possible for a woman to beat all the men. This type of analysis provides a unique opportunity to gain insight into the physiological changes during multiday running in ultraendurance athletes.

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Section: Dehydration and Impaired Renal Function Due To Skeletal Muscmentioning

confidence: 99%

The Effects of Running 1,200 km Within 17 Days on Body Composition in a Female Ultrarunner—Deutschlandlauf 2007

Knechtle¹,

Duff²,

Schulze³

et al. 2008

Research in Sports Medicine

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“…Marathon and especially ultra-marathon running as an eccentric exercise may cause skeletal muscle damage resulting in an increase in myocellular enzymes such as plasma creatine kinase (1)(2)(3) and myoglobin ( 1 ). Skeletal muscle damage and the corresponding increase in myocellular enzymes in plasma may lead to rhabdomyolysis, thus causing an impairment of renal function ( 4 ), reflected by a decline in the post-race creatinine clearance ( 5 ) and even renal failure in ultra-marathoners ( 6 ).…”

mentioning

confidence: 99%

“…In a marathon, renal function measured by using urine flow rates, creatinine clearance and protein excretion was not impaired ( 8 ). In ultra-marathoners, however, several reports about an impairment of renal function have been published (4)(5)(6). A net breakdown of body protein during endurance exercise has been shown and the mobilized amino acids were available for increased rates of oxidation and gluconeogenesis during an endurance performance ( 9 ).…”

mentioning

confidence: 99%

Branched-Chain Amino Acid Supplementation during a 100-km Ultra-Marathon^|^mdash;A Randomized Controlled Trial

Knechtle

Mrazek²,

Wirth³

et al. 2012

J Nutr Sci Vitaminol

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Summary Ultra-marathon running is supposed to increase the parameters of skeletal muscle damage and impair renal function. The purpose of this study was to investigate the effect of branched-chain amino acid supplementation on skeletal muscle damage and renal function during a 100-km ultra-marathon. Twenty-eight athletes were randomly divided into two groups, one group using branched-chain amino acid supplementation (BCAA) and a control group (CON). The athletes in the BCAA group were supplemented with a total of 50 g of an amino acid concentrate including 20 g of BCAA. The intake of energy, antioxidants and parameters of both skeletal muscle damage and renal function were determined. Race time was not different between BCAA and CON when controlled for the personal best time in a 100-km ultra-marathon. Neither the intake of energy and antioxidants nor the parameters of skeletal muscle damage and renal function were different between BCAA and CON. We concluded that BCAA-supplementation before and during a 100-km ultra-marathon had no effect on performance, skeletal muscle damage or renal function.

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“…AER has been reported in marathon runners 16 and has been associated with excessive application of the following exercises: squat calisthenics/squat thrust, 6 sit-ups, 11 crunches, 8 push-ups, 3,19 and weight lifting. 2,9,15,21 In this current case report, the patient developed exertional rhabdomyolysis after a very strenuous bout of push-up improvement training.…”

Section: Discussionmentioning

confidence: 99%