Acute Renal Failure, Hemolytic Anemia, and Thrombocytopenia in Poststreptococcal Glomerulonephritis

Medani, C R; Pearl, Phillip L.; Hall-Craggs, MA

doi:10.1097/00007611-198703000-00025

Cited by 17 publications

(15 citation statements)

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“…The outcome was good in all patients, as expected in APGN in contrast to D-HUS. In two of them (patients 3 and 4), HUS was also con®ned to the haematological ®ndings, and renal biopsy showed only features of APGN [8,11]. Histology in the two other patients (patients 5 and 6), was consistent with both HUS and APGN [2,15].…”

Section: Discussionmentioning

confidence: 88%

“…Other authors postulated a common pathway whereby an unknown microorganism would cause complement consumption, endothelial dysfunction and micro-angiopathy [13]. Prodromal diarrhoea was reported in three of the six patients in Table 1 [8,11,15], but E. coli 0157:H7 and other verotoxin producing bacteria were not isolated.…”

Section: Discussionmentioning

confidence: 93%

“…The simultaneous occurrence of HUS and APGN has rarely been reported in children [2,7,8,10,11,14,15]. Whether this relation is causal or accidental remains open to debate.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous occurrence of the haemolytic uraemic syndrome and acute post-infectious glomerulonephritis

Laube¹,

Sarkissian

Hailemariam

et al. 2001

European Journal of Pediatrics

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We report on two children, a 12-year-old boy and a 6-year-old girl, with simultaneous occurrence of clinical and laboratory features consistent with both diarrhoea-negative haemolytic uraemic syndrome (D-HUS) and acute post-infectious glomerulonephritis (APGN). Both presented with acute renal insufficiency, hypertension and oedema. Laboratory evaluation revealed micro-angiopathic anaemia with burr cells, thrombocytopenia, elevated lactic dehydrogenase and low complement C3. Urinalysis showed marked proteinuria and haematuria. Renal biopsy was characteristic of APGN, but not of HUS. The outcome was good in both children. Conclusion. The simultaneous occurrence of diarrhoea-negative haemolytic uraemic syndrome and acute post-infectious glomerulonephritis is rare. The outcome is generally good as is expected in the latter condition in contrast to the former.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 93%

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Simultaneous occurrence of the haemolytic uraemic syndrome and acute post-infectious glomerulonephritis

Laube¹,

Sarkissian

Hailemariam

et al. 2001

European Journal of Pediatrics

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“…Thrombocytopenia has only been associated with PSGN in a few case reports. The triad of hemolytic anemia, thrombocytopenia, and acute kidney injury occurred in a 13-year-old African American boy with a high ASO and low C3 [13]. A four-year-old Japanese boy was reported to have a low C3, “mild glomerulonephritis,” a negative throat culture and thrombocytopenia with platelet antigen-specific Fab fragment autoantibodies [14].…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis

Ayoob

Schwaderer

2016

International Journal of Nephrology

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The most common acute glomerulonephritis in children is poststreptococcal glomerulonephritis (PSGN) usually occurring between 3 and 12 years old. Hypertension and gross hematuria are common presenting symptoms. Most PSGN patients do not experience complications, but rapidly progressive glomerulonephritis and hypertensive encephalopathy have been reported. This paper reports 17 patients seen in 1 year for PSGN including 4 with atypical PSGN, at a pediatric tertiary care center. Seventeen children (11 males), mean age of 8 years, were analyzed. Ninety-four percent had elevated serum BUN levels and decreased GFR. Four of the hospitalized patients had complex presentations that included AKI along with positive ANA or ANCAs. Three patients required renal replacement therapy and two were thrombocytopenic. PSGN usually does not occur as a severe nephritis. Over the 12-month study period, 17 cases associated with low serum albumin in 53%, acute kidney injury in 94%, and thrombocytopenia in 18% were treated. The presentation of PSGN may be severe and in a small subset have associations similar to SLE nephritis findings including AKI, positive ANA, and hematological anomalies.

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“…TTP is characterized by the pentad of microangiopathic hemolytic anemia, thrombocytopenia, fever, acute renal injury, and neurological abnormalities (Copelovitch & Kaplan, 2008). TMA has been reported in 8 patients with APSGN, consisting of 5 children and 3 adults (Duvic et al, 2000;Izumi, et al, 2005;Laube, et al, 2001;Medani et al, 1987;Proesmans, 1996;Siebels et al, 1995;Tan et al, 1998). All patients exhibited severe hypertension.…”

Section: Thrombotic Microangiopathymentioning

confidence: 99%

Atypical Clinical Manifestations of Acute Poststreptococcal Glomerulonephritis

Watanabe¹

2011

An Update on Glomerulopathies - Clinical and Treatment Aspects

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Acute Renal Failure, Hemolytic Anemia, and Thrombocytopenia in Poststreptococcal Glomerulonephritis

Cited by 17 publications

References 0 publications

Simultaneous occurrence of the haemolytic uraemic syndrome and acute post-infectious glomerulonephritis

Simultaneous occurrence of the haemolytic uraemic syndrome and acute post-infectious glomerulonephritis

Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis

Atypical Clinical Manifestations of Acute Poststreptococcal Glomerulonephritis

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