Acute renal failure from carbamazepine.

Nicholls, D. P.; Yasin, Mensur Osman

doi:10.1136/bmj.4.5838.490

Cited by 21 publications

(10 citation statements)

References 1 publication

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“…The diagnosis of carbamazepine-induced granulomatous angiitis was made. Although, Nicolls and Yasin [14] reported carbam azepine-induced acute tubular necrosis accompanied by acute renal failure in 1971, the present case differs be cause of the presence of the granulomatous angiitis.…”

Section: Discussioncontrasting

confidence: 38%

Carbamazepine-Induced Granulomatous Nectrotizing Angiitis with Acute Renal Failure

Imai

Nakamoto

Hirokawa

et al. 1989

Nephron

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A 42-year-old male treated with carbamazepine developed a skin eruption in the trunk, followed by acute renal failure. Laboratory data revealed leukocytosis (15,700/mm³) with eosinophilia (37%). A renal biopsy disclosed granulomatous necrotizing angiitis that differed from classic periateritis nodosa and hypersensitivity angiitis. All drugs were discontinued immediately, and there was a gradual improvement of the renal function. A carefully performed provocation test using carbamazepine was positive. We made a diagnosis of carbamazepine-induced granulomatous necrotizing angiitis. Only 6 cases of drug-induced granulomatous angiitis have been reported prior to the present case. Drug-induced granulomatous angiitis is often fatal. The present report suggests the importance of making a diagnosis quickly, and providing adequate treatment in order to prevent a fatal course.

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Section: Discussioncontrasting

confidence: 38%

Carbamazepine-Induced Granulomatous Nectrotizing Angiitis with Acute Renal Failure

Imai

Nakamoto

Hirokawa

et al. 1989

Nephron

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“…It has also been reported to induce tubulointerstitial nephritis in the con text of an allergic reaction [1][2][3][4][5]. Tubular ne crosis caused by carbamazepine has been re poned [6]. We observed a new case of tubular necrosis as a toxic reaction secondary to overdosage.…”

mentioning

confidence: 58%

Carbamazepine-lnduced Acute Renal Failure

Jubert

Almirall

Casanovas

et al. 1994

Nephron

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“…Taking these facts into account, carbamazepine is the most likely cause of acute tubulointerstitial nephritis in the present case. Carbamazepineinduced tubulointerstitial nephritis was initially reported in 1972 (5) and only a few cases have since been reported (6-13). To our knowledge, this is the first autopsy report to describe histological evidence of multiple organ involvement in carbamazepine-induced tubulointerstitial nephritis.…”

Section: Discussionmentioning

confidence: 99%

“…Various adverse effects of carbamazepine have been recognized, including acute and chronic interstitial nephritis. Nicholls et al reported a case of carbamazepine-induced acute renal failure with histological evidence of tubular damage in 1972 (5). Since then, only a few cases of carbamazepine-induced interstitial nephritis have been documented (6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Acute Tubulointerstitial Nephritis with Multiple Organ Involvement Including Fatal Adrenalitis: A Case Report with Autopsy Findings

et al. 2012

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A 68-year-old woman with Alzheimer's disease developed renal dysfunction after starting carbamazepine for epilepsy. Although Ga-67 citrate scintigraphy strongly suggested interstitial nephritis, renal biopsy was not possible due to her overall state. At 61 days after admission, she died of unexplained shock. At autopsy, severe infiltration of T lymphocytes was noted, not only in the renal interstitium but also in the liver, lungs, and adrenal glands. Adrenal failure was a possible cause of shock. In carbamazepine-induced interstitial nephritis, multiple organ involvement including fatal adrenalitis should be considered.

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Acute renal failure from carbamazepine.

Cited by 21 publications

References 1 publication

Carbamazepine-Induced Granulomatous Nectrotizing Angiitis with Acute Renal Failure

Carbamazepine-Induced Granulomatous Nectrotizing Angiitis with Acute Renal Failure

Carbamazepine-lnduced Acute Renal Failure

Acute Tubulointerstitial Nephritis with Multiple Organ Involvement Including Fatal Adrenalitis: A Case Report with Autopsy Findings

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