Acute renal failure due to leptospirosis grippotyphosa

Gerding, M.N.; Groen, Jan; Brouwer, Rianne; Jordans, J.G.M.; Osterhaus, Albert D. M. E.

doi:10.1007/bf01740824

Cited by 3 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the present case, there are other published reports, caused by different serovars, involving cases of anicteric leptospiral renal failure without major hepatic involvement or hemorrhagic complications that experienced complete restoration of kidney function (12)(13)(14).…”

Section: Discussionmentioning

confidence: 53%

Acute Interstitial Nephritis due to Leptospira grippotyphosa in the Absence of Weil’s Disease

Schmidhauser

Curioni

Bernasconi

2013

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 53%

Acute Interstitial Nephritis due to Leptospira grippotyphosa in the Absence of Weil’s Disease

Schmidhauser

Curioni

Bernasconi

2013

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

show abstract

Usefulness of Serologic Analysis as a Predictor of the Infecting Serovar in Patients with Severe Leptospirosis

2003

View full text Add to dashboard Cite

The diagnosis of leptospirosis is often made using the microscopic agglutination test (MAT), in which live antigens representing >20 serogroups undergo reaction with patient serum samples to detect agglutinating antibodies. Data derived from this assay are often used to infer the identity of the infecting leptospiral serovar or serogroup; however, paradoxical reactions and cross-reactions between serogroups are common. To evaluate the usefulness of this approach, data on culture-proven cases of leptospirosis that occurred in Barbados from January 1980 through December 1998 were reviewed. A total of 151 isolates of 4 serovars were identified. The sensitivity of MAT for the prediction of the infecting serovar was determined. Overall, the predominant serogroup at a titer of >or=100 correctly predicted 46.4% of all serovars isolated. If a titer of >or=800 was used as the cutoff, sensitivity decreased slightly to 44.4%. The overall specificity for all serogroups was 64.8%. Serologic analysis appeared to be of little value for the identification of the infecting serovar in individual cases of leptospirosis in humans. Presumptive serogroup reactivity data should be used only to gain a broad idea of the serogroups present at the population level.

show abstract

A novel tetravalentLeptospirabacterin protects against infection and shedding following challenge in dogs

et al. 2013

View full text Add to dashboard Cite

Recent evidence based on the current epidemiological situation suggests that vaccines against canine leptospirosis in Europe should be directed against infection with Leptospira interrogans (sensu lato) serogroups Canicola, Icterohaemorrhagiae, Grippotyphosa and Australis. In the eight studies presented here, dogs were vaccinated with Nobivac L4 (MSD Animal Health), a new tetravalent inactivated vaccine containing antigen from four strains representing these four serogroups. The dogs were then challenged, together with unvaccinated control dogs, using heterologous strains from the same four serogroups. In four of the studies, pups without agglutinating antibodies against the four serogroups were vaccinated with Nobivac L4 vaccine. In a further four studies, Nobivac L4 vaccine was given 48 hours after administration of antiserum from vaccinated dogs designed to mimic the serological status of pups with maternally derived antibodies against these serogroups. In all eight studies, vaccine efficacy was assessed in terms of antibody response, clinical signs, fever, thrombocyte count, frequency of positive isolation of challenge organisms from blood, urine and kidney and frequency of interstitial nephritis. The results demonstrate that Nobivac L4 vaccine induces sterile immunity against leptospiraemia and renal infection with strains of serogroups Canicola, Icterohaemorrhagiae and Grippotyphosa, and induces sterile immunity against leptospiraemia with a strain of serogroup Australis. Since sterile immunity was achieved in pups pretreated with antiserum as well, it can be concluded that this vaccine is also likely to be efficacious in the face of maternally derived antibodies in pups from the age of six weeks.

show abstract

Acute renal failure due to leptospirosis grippotyphosa

Cited by 3 publications

References 7 publications

Acute Interstitial Nephritis due to Leptospira grippotyphosa in the Absence of Weil’s Disease

Acute Interstitial Nephritis due to Leptospira grippotyphosa in the Absence of Weil’s Disease

Usefulness of Serologic Analysis as a Predictor of the Infecting Serovar in Patients with Severe Leptospirosis

A novel tetravalentLeptospirabacterin protects against infection and shedding following challenge in dogs

Contact Info

Product

Resources

About