Acute Renal Failure Due to Vancomycin Toxicity in the Setting of Unmonitored Vancomycin Infusion

Vora, Shagufta

doi:10.1080/08998280.2016.11929491

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…The drug has also been shown to interfere with the normal reabsorption function of the proximal renal tubule epithelium and alter the mitochondrial function of these cells. Moreover, vancomycin can induce AIN [ 34 ]. Gentamicin is an aminoglycoside that induces nephrotoxicity through the endocytosis and accumulation of antibiotics in the epithelial cells of the proximal tubule [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Drug-Induced Acute Kidney Injury: A Study from the French Medical Administrative and the French National Pharmacovigilance Databases Using Capture-Recapture Method

Rolland

Garnier

Meunier

et al. 2021

JCM

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Background: Acute kidney injury (AKI) is a public health concern. Among the pathological situations leading to AKI, drugs are preventable factors but are still under-notified. We aimed to provide an overview of drug-induced AKI (DIAKI) using pharmacovigilance and medical administrative databases Methods: A query of the PMSI database (French Medical Information System Program) of adult inpatient hospital stays between 1 January 2017 and 31 December 2018 was performed using ICD-10 (International Classification of Diseases 10th revision) codes to identify AKI cases which were reviewed by a nephrologist and a pharmacovigilance expert to identify DIAKI cases. In parallel, DIAKIs notified in the French Pharmacovigilance Database (FPVDB) were collected. A capture-recapture method was performed to estimate the total number of DIAKIs. Results: The estimated total number of DIAKIs was 521 (95%CI 480; 563), representing 20.0% of all AKIs. The notification was at a rate of 12.9% (95%CI 10.0; 15.8). According to the KDIGO classification, 50.2% of the DIAKI cases were stage 1 and 49.8% stage 2 and 3. The mortality rate was 11.1% and 9.6% required hemodialysis. Conclusion: This study showed that drugs are involved in a significant proportion of patients developing AKI during a hospital stay and emphasizes the severity of DIAKI cases.

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Section: Discussionmentioning

confidence: 99%

Drug-Induced Acute Kidney Injury: A Study from the French Medical Administrative and the French National Pharmacovigilance Databases Using Capture-Recapture Method

Rolland

Garnier

Meunier

et al. 2021

JCM

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“…In response to the pervasiveness of MRSA infections, the efficacies of a range of antibiotic treatments have been assessed. Although vancomycin, which we used as a positive control treatment in this study, is one of the representative drugs effective in the treatment of MRSA infections, the use of this antibiotic poses risks of acute kidney injury and Redman syndrome, and moreover there is currently an increasing incidence of VRSA infections being reported [ 8 , 9 , 10 , 11 ]. As an effective alternative medication, we propose the administration of PKEO, which has a number of beneficial attributes.…”

Section: Discussionmentioning

confidence: 99%

Pinus koraiensis Essential Oil Attenuates the Pathogenicity of Superbacteria by Suppressing Virulence Gene Expression

Kim,

Park

et al. 2023

Molecules

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In the quest to combat infections attributable to antibiotic-resistant superbacteria, an essential oil derived from the needles of Pinus koraiensis Sieb. et Zucc. (PKEO) has emerged as a promising solution. In this study, we demonstrate that PKEO can be used to inhibit the growth, glucose metabolite acidogenicity, and biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA). Quantitative PCR analysis provided direct evidence that PKEO reduces the mRNA expression of the accessory gene regulator A (agrA) and staphylococcal accessory regulator A (sarA), thereby indicating its inhibitory effect on pathogenic regulatory genes. Chromatographic analyses of PKEO identified terpene hydrocarbons as prominent essential oil constituents. These compounds, notably α-pinene, limonene, and β-caryophyllene, have been established to have antimicrobial properties. Our findings indicate that an oil derived from P. koraiensis can effectively combat antibiotic-resistant strains by disrupting the pathogenicity regulatory system, thereby establishing PKEO as a promising candidate for the treatment of MRSA infections.

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“…As MRSA is considered as a well-known MDR strain, it is tremendously difficult to be treated to normal ranges of antibiotics. Moreover, next generations of antibiotics also impart toxic side effects on human body [39]. The treatment is further complicated as MRSA are known as strong biofilms producer [40].…”

Section: Discussionmentioning

confidence: 99%

The IR-RF alpha-Efficiency of K-feldspar

Kreutzer

Martin

Dubernet

et al. 2018

Radiation Measurements

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Acute Renal Failure Due to Vancomycin Toxicity in the Setting of Unmonitored Vancomycin Infusion

Cited by 10 publications

References 10 publications

Drug-Induced Acute Kidney Injury: A Study from the French Medical Administrative and the French National Pharmacovigilance Databases Using Capture-Recapture Method

Drug-Induced Acute Kidney Injury: A Study from the French Medical Administrative and the French National Pharmacovigilance Databases Using Capture-Recapture Method

Pinus koraiensis Essential Oil Attenuates the Pathogenicity of Superbacteria by Suppressing Virulence Gene Expression

The IR-RF alpha-Efficiency of K-feldspar

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