Acute Renal Failure Associated with Acute Non-fulminant Hepatitis A: A Case Report and Review of Literature

Fan, Pei‐Chun; Chen, Yung‐Chang; Tian, Ya-Chung; Chang, Chih‐Hsiang; Fang, Ji‐Tseng; Yang, Chih‐Wei

doi:10.3109/08860220903125306

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…Acute kidney injury can occur in patients with HAV infection with and without ALF 40–42 . Mechanisms whereby renal dysfunction may occur during acute HAV infection include hypovolemia, tubular toxicity induced by hyperbilirubinemia and immune-complex mediated nephritis 41–43 .…”

Section: Discussionmentioning

confidence: 99%

“…The management is usually supportive although there have been reports of improvement of renal function after hemodialysis, plasmapheresis and corticosteroid use 41, 43–46 . The majority of patients recover a normal renal function although permanent renal insufficiency has been reported 40, 46 . We found that 3% of patients with HAV- induced ALF required simultaneous liver-kidney transplantation.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting List

et al. 2015

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Background & Aims Although renal dysfunction is a known complication of acute liver failure (ALF), its frequency, severity and impact among patients with ALF on the US liver transplant list are not well defined. Methods Organ Procurement and Transplantation data for ALF patients listed as status 1/1A from 2002–2012 were analyzed. The frequency and severity of renal dysfunction at the time of listing [the latter was categorized in 5 stages using estimated GFR (eGFR) according to Chronic Kidney Disease Epidemiology Collaboration creatinine 2009 equation) were determined and the association between renal dysfunction and waiting list mortality was assessed using Cox proportional hazard regression analysis. Results There were a total of 2,280 adult patients with ALF, including 56% with renal dysfunction (defined as eGFR <60 ml/min/1.73m2) at listing. The highest proportion of patients with renal dysfunction was among those with ALF caused by hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome, fatty liver disease of pregnancy, heat stroke/hyperthermia-, hepatitis A virus, drug-induced liver injury due to acetaminophen (APAP), phenytoin, trimethoprim-sulfamethoxazole and macrolides. Despite the fact that 69% (468/674) of patients with APAP-induced ALF listed as status 1/1A had renal dysfunction, only 0.9% underwent simultaneous liver-kidney transplantation. Six-week survival probabilities in patients with ALF on the liver transplant waiting list were 71%, 59%, 56%, 59% and 42% with renal dysfunction stages of 1, 2, 3, 4, and 5, respectively. Multivariate analysis showed that after controlling for age, etiology of ALF, INR, total bilirubin and region, the relative risk of death increased progressively as eGFR declined (P<0.0001). Conclusions Among patients with ALF on the liver transplant waiting list, renal dysfunction was common (overall prevalence of 56%). Most importantly, severe renal dysfunction was associated with significantly increased mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting List

et al. 2015

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“…Although liver diseases cause irreversible renal dysfunction, such as hepatitis C virus-induced cryoglobulinemia, membranoproliferative glomerulonephritis, HRS causes reversible renal failure [ 8 , 9 ]. HRS is difficult to clinically distinguish from primary renal failure.…”

Section: Discussionmentioning

confidence: 99%

A Case of Hepatorenal Syndrome and Abdominal Compartment Syndrome with High Renal Congestion

et al. 2017

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Patient: Male, 40Final Diagnosis: Hepatorenal syndromeSymptoms: Abdominal distensionMedication: —Clinical Procedure: —Specialty: NephrologyObjective:Rare co-existance of disease or pathologyBackground:Hepatorenal syndrome (HRS) is a reversible renal impairment that occurs in patients with acute liver failure and advanced liver cirrhosis. HRS is due to a renal vasoconstriction that results from extreme vasodilatation. It is therefore a functional disorder, not associated with structural kidney damage. On the other hand, end-stage liver diseases are often complicated by massive ascites. Massive ascites may cause abdominal compartment syndrome (ACS), which includes impairment of renal blood flow, but there are no reports indicating that kidney lesions caused by ACS may pathologically contribute to end-stage liver diseases.Case Report:A 40-year-old man with acute liver failure was admitted to our hospital. He was diagnosed with type 1 HRS and showed ACS at the same time. He died 30 days after admission. There were signs of congestion in the kidneys upon dissection and advanced erythroid fullness in the renal tubules.Conclusions:We report an autopsy case with HRS and ACS diagnosed with a clinical and histopathological consideration of liver and kidney. Further clinical studies are needed to improve management of renal failure in patients with acute liver failure and advanced liver cirrhosis.

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“…Acute kidney injury can occur in patients with HAV infection with and without ALF [40][41][42] . Mechanisms whereby renal dysfunction may occur during acute HAV infection include hypovolemia, tubular toxicity induced by hyperbilirubinemia and immune-complex mediated nephritis [41][42][43] .…”

Section: Author Manuscript Author Manuscriptmentioning

confidence: 99%

“…The management is usually supportive although there have been reports of improvement of renal function after hemodialysis, plasmapheresis and corticosteroid use 41,[43][44][45][46] . The majority of patients recover a normal renal function although permanent renal insufficiency has been reported 40,46 . We found that 3% of patients with HAV-induced ALF required simultaneous liver-kidney transplantation.…”

Section: Author Manuscript Author Manuscriptmentioning

confidence: 99%

481 Prevalence, Severity and Impact of Renal Dysfunction in Acute Liver Failure on the U.S. Liver Transplant Waiting List

Urrunaga¹,

Mindikoğlu²

2014

Gastroenterology

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Acute Renal Failure Associated with Acute Non-fulminant Hepatitis A: A Case Report and Review of Literature

Cited by 12 publications

References 22 publications

Prevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting List

Prevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting List

A Case of Hepatorenal Syndrome and Abdominal Compartment Syndrome with High Renal Congestion

481 Prevalence, Severity and Impact of Renal Dysfunction in Acute Liver Failure on the U.S. Liver Transplant Waiting List

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