Acute renal failure and/or rhabdomyolysis due to multiple bee stings: A retrospective study

Deshpande, Prasanna R; Farooq, KK Ahsan; Bairy, Manohar; Attur, Ravindra Prabhu

doi:10.4103/1947-2714.109202

Cited by 19 publications

(14 citation statements)

References 29 publications

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“…Recently, Bhatta et al and Ghosh et al reported the occurrence of ATIN after a relatively asymptomatic period varying from 1 to 2 weeks following exposure to wasp stings 9 10. Even though there are multiple reports of ATIN following wasp stings, a literature search revealed only a single case report of ATIN following bee stings 11. Unlike the previous reports, both patients had exposure to a single sting.…”

Section: Discussionmentioning

confidence: 81%

Acute tubulointerstitial nephritis following hymenopteran stings

Ezhilnilavan

Priyamvada

Srinivas

et al. 2018

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 81%

Acute tubulointerstitial nephritis following hymenopteran stings

Ezhilnilavan

Priyamvada

Srinivas

et al. 2018

Postgraduate Medical Journal

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“…Such habits have kept the people more vulnerable to sustain wasp bite and related complications such as hemolysis, rhabdomyolysis, coagulation, cardiac, pulmonary, hepatic, and nervous system disorders, hypertension, and AKI. [33][34][35][36] Sigdel et al reported a case series of 18 patients from a tertiary hospital in Kathmandu, Nepal who sustained acute renal failure (ARF) requiring dialysis following wasp bite. 37 The number of admitted patients who sustained rhabdomyolysis without AKI could have been much higher than what we have reported in this study because we have included only those patients who developed AKI.…”

Section: Discussionmentioning

confidence: 99%

Comparison between Rhabdomyolysis Induced and Septic Acute Kidney Injury in Central Nepal

et al. 2019

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Background: Acute kidney injury (AKI) is one of the most serious complications of rhabdomyolysis (RM). We studied the clinical manifestations and prognosis of rhabdomyolysis induced AKI and compared it with septic AKI among hospitalized patients. Methods: A prospective study was conducted at Chitwan Medical College between January 2017 to June 2018 to compare AKI secondary to rhabdomyolysis (RM-AKI) and sepsis (SA-AKI). AKI was diagnosed as per Kidney Disease Improving Global Outcomes (KDIGO) 2012 guidelines. Rhabdomyolysis was diagnosed if serum creatinine phosphokinase raised >5 times the upper limit of normal level and sepsis as an increase of two or more points in the Sequential Organ failure Assessment (SOFA) score with the evidence of infection. Results: A total of 145 patients with AKI (21 with RM and 124 with sepsis) were included in the study. Mean age of the patients was 43.7 years with majority (54%) being males. Wasp bite and bee sting combined together (47.6%) were the most common causes for RM-AKI whereas pneumonia accounted for 46.6% of the septic AKI. Serum creatinine (SCr) at admission and at discharge were 3.8 and 1.4 mg/dL respectively in RM-AKI group; and 2.4 and 1.6 mg/dL in septic AKI group. Duration of stays in the hospital (9.2 versus 6.4 days) and ICU (4.2 versus 3.7 days) were longer in RM than in septic AKI. In hospital mortality was 4.8% in RM and 8.9% in septic AKI. Conclusions: This study has found that, despite a longer duration of hospital stay, RM-AKI had a lower in-hospital mortality than septic AKI.

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“…Renal injury with renal failure represents severe envenoming. The majority of reports in the literature are case reports with laboratory findings and some with renal pathology . Apamin and tertiapin are the two peptide toxins in bee venom that target K channels.…”

Section: Scorpion Envenoming and Renal K Transportmentioning

confidence: 99%

“…The majority of reports in the literature are case reports with laboratory findings and some with renal pathology. 55,56 Apamin and tertiapin are the two peptide toxins in bee venom that target K channels. Apamin inhibits SK and KATP, and tertiamin inhibits ROMK1.…”

Section: Bee Stings and Renal Ion Transportmentioning

confidence: 99%

Animal toxins and renal ion transport: Another dimension in tropical nephrology

Sitprija

2016

Nephrology

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Sitprija et al have reviewed the issue regarding renal vascular and renal tubular ion channels and transporters involved in animal toxin injury. Several vascular and renal tubular ion channels have been modulated by various animal toxins, resulting in hemodynamic alterations. ABSTRACT:Renal vascular and tubular ion channels and transporters involved in toxin injury are reviewed. Vascular ion channels modulated by animal toxins, which result in haemodynamic alterations and changes in blood pressure, include ENaC/Degenerin/ASIC, ATP sensitive K channels (KATP), Ca activated K channels (Kca) and voltage gated Ca channels, mostly L-type. Renal tubular Na channels and K channels are also targeted by animal toxins. NHE3 and ENaC are two important targets. NCC and NKCC may be involved indirectly by vasoactive mediators induced by inflammation. Most renal tubular K channels including voltage gated K channels (Kv1), KATP, ROMK1, BK and SK are blocked by scorpion toxins. Few are inhibited by bee, wasp and spider venoms. Due to small envenoming, incomplete block and several compensatory mechanisms in renal tubules, serum electrolyte charges are not apparent. Changes in serum electrolytes are observed in injury by large amount of venom when several channels or transporters are targeted. Envenomings by scorpions and bees are examples of toxins targeting multiple ion channels and transporters.

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Acute renal failure and/or rhabdomyolysis due to multiple bee stings: A retrospective study

Cited by 19 publications

References 29 publications

Acute tubulointerstitial nephritis following hymenopteran stings

Acute tubulointerstitial nephritis following hymenopteran stings

Comparison between Rhabdomyolysis Induced and Septic Acute Kidney Injury in Central Nepal

Animal toxins and renal ion transport: Another dimension in tropical nephrology

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