Acute renal failure and non‐Hodgkins lymphoma in a patient with minimal change glomerulonephritis

Cronin, C. J.; Carmody, E.; Ryan, F.; Carmody, M.

doi:10.1111/j.1365-2796.1990.tb00194.x

Cited by 11 publications

(10 citation statements)

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“…Functional abnormalities of B cells and T cells, and increased or decreased levels of immunoglobulins, have also been reported [14,16]. Nephrotic syndrome occurs frequently in association with various malignant processes, including some carcinomas, and hematological malignancies (malignant lymphoma [9][10][11], and CLL [13][14][15]). Nephrotic syndrome occurs frequently in association with various malignant processes, including some carcinomas, and hematological malignancies (malignant lymphoma [9][10][11], and CLL [13][14][15]).…”

Section: Discussionmentioning

confidence: 99%

“…Eagan and Lewis [20] reviewed 52 cases of Hodgkin's disease with nephrotic syndrome, and found minimal change nephrotic glomerulonephritis in 50% of them. In non-Hodgkin's lymphoma, minimal change glomerulonephritis and mesangial proliferative glomerulonephritis are less frequently observed than in Hodgkin's disease [10,22]. It has been suggested that impairment of T-cell mediated immunity induces minimal change nephrotic glomerulonephritis in Hodgkin's disease [9,21].…”

Section: Discussionmentioning

confidence: 99%

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Myelodysplastic syndromes with nephrotic syndrome

et al. 1999

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It is sometimes reported that the immunological abnormalities in myelodysplastic syndromes (MDS) induce autoimmune disease (i.e., acute systemic vasculitic syndrome, chronic cutaneous vasculitis, polyneuropathy, relapsing polychondritis, and steroid-responsive pulmonary disorders). We investigated the clinical features of patients with MDS accompanied by nephrotic syndrome. We enrolled 125 patients with MDS who were admitted between January 1979 and May 1996 in this study. The renal function was assessed based on the laboratory data and the findings at the physical examination. The diagnoses of nephrotic syndrome and glomerular disease were established when 24-hr urinary excretion was more than 3.5 g and serum total protein was less than 6.0 g/dl, and when the 24-hr protein excretion was more than 1.5 g. Five patients (4%) had glomerular disease, and three (2.4%) had nephrotic syndrome. Of the five patients with glomerular disease, two had refractory anemia (RA), and three had chronic myelomonocytic leukemia (CMMOL). Three of the total 11 patients with CMMOL were diagnosed as having nephrotic syndrome. Among the CMMOL patients, those with nephrotic syndrome showed higher absolute monocyte numbers than did those without nephrotic syndrome (8830 +/- 4677/microl vs. 3061 +/- 2887/microl, P = 0.03). One CMMOL patient was treated with VP-16 and hydroxyurea. As the white blood cell count in this patient decreased, the 24-hr urine protein excretion and the serum tumor necrosis factor alpha level decreased. The relationship between nephrotic syndrome and CMMOL was not clear. High monocyte count and the serum cytokines in MDS patients may play a partial role in the evolution of glomerulonephritis, and CMMOL may be closely related to nephrotic syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Myelodysplastic syndromes with nephrotic syndrome

et al. 1999

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“…Renal function is usually not altered in minimal-change glomerulonephritis associated with Hodgkin's disease [&lo]. In contrast, the more severe types of NHL-associated glomerulonephritis frequently result in full-blown nephrotic syndrome [7,8,48,50,53,56,, impaired renal function [7][8][9]11,46], or renal failure [41,47,49,50].…”

Section: Discussionmentioning

confidence: 99%

“…Whereas renal failure in idiopathic nephrotic syndrome rarely responds to treatment, renal function in lymphomaassociated glomerulonephritis generally improves after initiation of chemotherapy and may even return to normal [8,11,41,43,46,49,50,60]. However, renal function in NHL-associated glomerulonephritis may be normal at time of diagnosis [8] and deteriorate subsequent to chemotherapy 1 1 1 3 1 1.…”

Section: Discussionmentioning

confidence: 99%

Association of primary renal non-Hodgkin's lymphoma with mesangioproliferative glomerulonephritis

et al. 1996

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A 27-year-old male developed nonoliguric renal failure. Renal biopsy of the left kidney showed infiltration by a diffuse large-cell non-Hodgkin's lymphoma (NHL). Laparoscopy, CT scans of the abdomen and thorax, and bone-marrow biopsy revealed no further manifestations of lymphoma. Primary renal NHL was diagnosed. The patient attained complete remission with cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) chemotherapy and remained disease-free for 13 years. Eight years after his first presentation, the patient developed acute oliguric renal failure with nephrotic syndrome. Mesangioproliferative glomerulonephritis was diagnosed in a biopsy of the left kidney. Chronic hemodialysis was required until cadaver kidney transplantation was successfully performed 5 years later. Although the association of NHL and glomerulonephritis has been described several times before, to our knowledge this is the first report of glomerulonephritis in primary renal lymphoma.

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“…Glomerular lesions have been de scribed during the course of Hodgkin's disease [5], The most common renal lesion is minimal-change disease with ne phrotic syndrome (41 cases described in the literature). Nephrotic syndrome usually occurs early in the course of the disease and may even constitute a presenting symptom [6,7], Cure of the disease usually results in remission of proteinuria [8], Nephrotic syndrome may announce a re lapse of the hematological disorders [9], Crescentic glomer ulonephritis associated with anti-G BM antibodies has been reported in 6 cases of Hodgkin's disease [5] (whereas circu lating anti-G BM antibodies were always present). In our observation, extended survey eliminated the possibility of recurrence of Hodgkin's disease, and there were no anti-GBM antibodies found.…”

Section: Discussionmentioning

confidence: 99%

Wegener’s Granulomatosis with Antiproteinase-3 Antibodies Occurring after Hodgkin’s Disease

Gratadour

Fouque²,

Laville³

et al. 1993

Nephron

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We describe the first association between Hodgkin’s lymphoma and Wegener’s granulomatosis, heralded by renal involvement. A 43-year-old man developed rapidly progressive glomerulonephritis requiring chronic hemodialysis 8 months after remission of Hodgkin’s lymphoma. At that moment, no extrarenal involvement was found, despite extensive investigation. Antineutrophil cytoplasm antibodies were positive, without specificity for proteinase-3 or myeloperoxydase. Six months after beginning hemodialysis, multiple pulmonary nodules appeared, along with rapid clinical worsening. A surgical biopsy was performed which disclosed a giant cell granuloma. Antimyeloperoxydase antibodies remained negative, whereas proteinase-3 antibodies became positive. Wegener’s granulomatosis was diagnosed and treatment with cyclophosphamide and steroids was started. Clinical and radiological improvement occurred promptly. Eleven months after treatment, both Wegener’s disease and Hodgkin’s lymphoma remained in remission.

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Acute renal failure and non‐Hodgkins lymphoma in a patient with minimal change glomerulonephritis

Cited by 11 publications

References 9 publications

Myelodysplastic syndromes with nephrotic syndrome

Myelodysplastic syndromes with nephrotic syndrome

Association of primary renal non-Hodgkin's lymphoma with mesangioproliferative glomerulonephritis

Wegener’s Granulomatosis with Antiproteinase-3 Antibodies Occurring after Hodgkin’s Disease

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