Acute renal failure after amphetamine presenting with loin pain

Repeated Administration of d-Amphetamine Results in a Time-dependent and Dose-independent Sustained Increase in Urinary Excretion of p-Hydroxyamphetamine in Mice

“…This effect is probably due to P450-mediated transformation of methamphetamine and amphetamine to their N-oxygenated metabolites, namely to N-hydroxymethamphetamine and Nhydroxyamphetamine, with subsequent inhibition of the enzyme system, as reviewed by Yamada et al 2) Another factor contributing for this outcome could be also the observed amphetamine-induced nephrotoxic effects, with the consequent impairment of kidney function. Kidney damage has been reported as a consequence of human amphetamine abuse 7,8,[21][22][23] and can be due to a combination of the direct renal effects of amphetamine and/or its metabolites, together with the amphetamineinduced rhabdomyolysis (and consequent deposit of the nephrotoxicant myoglobin in the kidney) hyperthermia and coagulopathy. The histological features of amphetamine-induced kidney damage in mice are shown for the first time in the present study, although an urinary biomarker of kidney toxicity (N-acetyl-β-D-glucosaminidase) was already shown to increase during amphetamine administration in rats.…”

“…Thus, the aim of this study was to evaluate the influence of dose and repeated administration of d-amphetamine on the urinary excretion of d-amphetamine and HA in the mouse. Liver and kidney histopathology was also evaluated, since amphetamine has been shown to provoke hepatotoxicity 6) and nephrotoxicity, 7,8) and these effects may influence its own metabolism and excretion.…”

Über die Aristolochia-Nephropathie - Phytotherapie -

“…Möglicherweise sind Interaktionen zwischen den verwendeten Appetithemmern und den Aristolochiasäurehaltigen Kräutern für die Nierenschäden verantwortlich. Zwar ist bei Dexfenfluramin, Fenfluramin oder Diethylpropion keine Nephrotoxizität bekannt, aber für den Appetithemmer Amphetamin [15,28], der ein ähnlich wirkendes Sympathikomimetikum wie Diethylpropion ist. Wahrscheinlich sind als zusätzliche Faktoren auch die Reduktionskost, das Diuretikum Acetazolamid und möglicherweise das Laxans mitbeteiligt.…”

Methamphetamine use in deceased kidney donors impairs one‐yr graft function*

“…MA use is also associated with high‐risk behaviors that result in increased rates sexually transmitted diseases (Hepatitis, HIV) and traumatic injuries (5, 11, 12). While much of the literature is weighted toward neurotoxic and cardiotoxic effects, there is growing evidence of adverse renal, hepatobiliary, and immunological effects (5, 13–19).…”

“…This juxtaposition highlights a predictable forecast of more potential deceased donors with histories of MA exposure. While the effect of MA exposure on kidney graft survival is not known, there is mounting evidence in support of short and long‐term renal dysfunction with acute or chronic MA use (13–18, 23). In light of the building evidence, it is plausible that donor MA exposure impairs renal function in recipients.…”