Acute Renal Allograft Rejection

Mitchell, David; Am, Roza; Ce, Spritzer; Pollack, H M; Ph, Arger; Alavi, Abass; Jorkasky, Diane K.; Cf, Barker; Tomaszewski, Jeffrey J.; Naji, Abderrahim

doi:10.1097/00004728-198707000-00020

Cited by 14 publications

(1 citation statement)

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“…In this paper, we demonstrate sodium images of kidneys in guinea pigs at 2.1 T, using a model of renal ischemia. Though the corticomedullary contrast has been utilized for the diagnosis of renal ischemia in the proton image, the corticomedullary contrast ratios provide nonspecific information about renal pathology, such as renal infarction and ischemia, acute tubular necrosis, glomerulonephritis, transplant rejection, cyclosporine toxicity, acute and chronic renal failure, and renal artery stenosis (6)(7)(8). Proton imaging is not very useful for the diagnosis of acute renal ischemia.…”

Section: Introductionmentioning

confidence: 99%

Sodium‐23 MR imaging of the kidney in guinea pig at 2.1 T, following arterial, venous, and ureteral ligation

Maeda

Seo

Murakami

et al. 1990

Magnetic Resonance in Med

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In vivo 23Na magnetic resonance images of guinea pig kidney were obtained at 2.1 T using a spin-echo sequence with an echo time of 19 ms. The intact kidney showed a very strong signal intensity in the sodium image. The signal intensity of the kidney decreased to 55% after ligation of the renal artery together with the vein and the ureter. The total sodium content in the excised kidney after arterial occlusion, measured by flame photometry, was 24% higher than that in the intact kidney. The transverse relaxation time (T2) of the extracellular sodium in the isolated kidney decreased to one-third of that in the intact kidney. This shortening of T2 may be partly responsible for the decrease in the 23Na signal intensity from the kidney after arterial occlusion.

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Section: Introductionmentioning

confidence: 99%

Sodium‐23 MR imaging of the kidney in guinea pig at 2.1 T, following arterial, venous, and ureteral ligation

Maeda

Seo

Murakami

et al. 1990

Magnetic Resonance in Med

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MR findings in diffuse renal parenchymal disease

Kettritz

Semelka

Brown

et al. 1996

Magnetic Resonance Imaging

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This study evaluates the MR appearance of the kidney in diffuse renal parenchymal diseases, using precontrast, and immediate and delayed postgadolinium chelate (Gd), spoiled gradient echo (SGE), and pre- and post-Gd, T1-weighted, fat-suppressed spin-echo MR images to determine if characteristic findings exist for various types of renal disease. One hundred twenty-one patients with renal disease underwent MRI. Underlying diagnoses included: (a) glomerular disease (GD), (b) tubulointerstitial disease (TID), (c) microvascular disease (MVD), (d) ischemic nephropathy (INP), (e) obstructive nephropathy (ON), (f) infectious renal disease (IRD), (g) sickle cell disease (SCD), (h) renal cortical necrosis (CN), and (i) renal insufficiency of unknown etiology (UE). MR examinations of 22 patients with normal kidneys (NK) were evaluated as a control group. The presence of corticomedullary differentiation (CMD) demonstrated strong inverse correlation with serum creatinine concentration (SCr) (r = -.568, P < .001). Mean thickness of the renal cortex was 8.4 and 7.8 mm in patients with NK and Gd, respectively. The mean cortical thickness in patients with MVD, TID/Chemo, INP, and ON was 5.2, 5.6, 5.5, and 4.3 mm, respectively, significantly thinner than the renal cortex in the NK and GD groups (P < .01). Irregularity of the renal cortex was more frequent in MVD (60.9%), IRD (62.5%), ON (55.6%), and TID/other (53.8%) than in GD (3.8%) and NK (0%) (P < .01). Diffuse high SI of the entire medulla on delayed postcontrast images was observed in 25 (20.7%) of the patients with renal disease and none of the NK group. Although no pathognomonic features were found, certain findings were observed that may correlate with the etiology of the kidney disease and, therefore, assist in the differential diagnosis of renal parenchymal disease.

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