Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats

Yamasaki, Masao; Mansho, Keiko; Ogino, Yoichiro; Kasai, Michio; Tachibana, Hirofumi; Yamada, Koji

doi:10.1016/s0955-2863(00)00116-9

Cited by 36 publications

(22 citation statements)

References 24 publications

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“…36 A decrease in leptin has also been observed in rats. 37 This hypothesis is supported by the observation that hyperinsulinemia and liver steatosis are partially reversed when hypoleptinemia is normalized by leptin infusion in CLA lipoatrophic mice. 34 However, there is conflicting evidence regarding the effects of CLA supplementation on plasma leptin in humans.…”

Section: Discussionmentioning

confidence: 87%

Conjugated Linoleic Acid Impairs Endothelial Function

Taylor

Williams

Rhys

et al. 2006

ATVB

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Objectives-To determine the effect of dietary supplementation with conjugated linoleic acid (CLA) on body mass index (BMI), body fat distribution, endothelial function, and markers of cardiovascular risk. Methods and Results-Forty healthy volunteers with BMI Ͼ27 kg/m 2 were randomized to receive a CLA isomeric mixture or olive oil in a 12-week double-blind study. Subcutaneous body fat and abdominal/hepatic fat content were assessed using skin-fold thicknesses and computed tomography scanning, respectively. Endothelial function was assessed by brachial artery flow-mediated dilatation (FMD). Plasma isoprostanes were measured as an index of oxidative stress. CLA supplementation did not result in a significant change in BMI index or total body fat. There was a significant decrease in limb (Ϫ7.8 mm, PϽ0.001), but not torso skin-fold thicknesses or abdominal or liver fat content. Brachial artery FMD declined (Ϫ1.3%, Pϭ0.013), and plasma F2-isoprostanes increased (ϩ91pg/mL, Pϭ0.042). Conclusions-A CLA isomeric mixture had at most modest effects on adiposity and worsened endothelial function. On the basis of these results, the use of the isomeric mixture of CLA as an aid to weight loss cannot be recommended.

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Section: Discussionmentioning

confidence: 87%

Conjugated Linoleic Acid Impairs Endothelial Function

Taylor

Williams

Rhys

et al. 2006

ATVB

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“…Delany et al (1999) reported that 1% dietary CLA supplementation significantly reduced plasma leptin level in mice after 6 wk of dietary treatment, but not at 8 and 12 wk. Yamasaki et al (2000) found that after only 1 wk of 2% dietary CLA supplementation, serum leptin levels were reduced in Sprague-Dawley rats fed a high-fat diet containing safflower oil. Safflower oil enhances the expression of leptin mRNA in rats and it was suggested that dietary CLA reduced this effect (Yamasaki et al, 2000).…”

Section: Discussionmentioning

confidence: 95%

“…Yamasaki et al (2000) found that after only 1 wk of 2% dietary CLA supplementation, serum leptin levels were reduced in Sprague-Dawley rats fed a high-fat diet containing safflower oil. Safflower oil enhances the expression of leptin mRNA in rats and it was suggested that dietary CLA reduced this effect (Yamasaki et al, 2000).…”

Section: Discussionmentioning

confidence: 95%

Influence of dietary conjugated linoleic acid on growth, meat quality, lipogenesis, plasma leptin and physiological variables of lipid metabolism in rabbits1

Corino

Mourot²,

Magni

et al. 2002

Journal of Animal Science

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ABSTRACT:We investigated the effects of conjugated linoleic acid (CLA) supplementation on growth, feed efficiency, carcass characteristics, meat quality, lipogenesis, and lipid metabolism in rabbits. One hundred forty-four New Zealand White rabbits, half males, half females, age 55 d, mean 1.8 kg BW, were randomly assigned to three weight-and sex-balanced feeding groups in which conventional pelleted diets were supplemented with 0, 0.25, or 0.5% of a CLA preparation. The CLA preparation contained 65% CLA isomers. Twelve rabbits (six males and six females from each group) were slaughtered at each of three slaughtering trials (2.5, 2.8, and 3.1 kg BW, or 76, 90, and 104 d of age). Conjugated linoleic acid supplementation did not influence growth performance (P ≥ 0.05) or carcass characteristics but reduced perirenal fat at heavier slaughtering weights (P = 0.09 at 2.8 kg BW; P < 0.01 at 3.1 kg BW). Conjugated linoleic acid reduced acetyl-CoAcarboxylase (CBX) activity in liver (P < 0.05) and adi-

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“…In our experiment, there was no effect of any treatment on serum leptin concentration. Dietary CLA reduced serum leptin levels in rats, mice and humans (Delany et al, 1999;Medina et al, 2000;Yamasaki et al, 2000b), whereas it was increased in lactating sows (Bontempo et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Impact of dietary betaine and conjugated linoleic acid on insulin sensitivity, protein and fat metabolism of obese pigs

Fernández‐Fígares

Lachica

Martín

et al. 2012

Animal

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To determine possible mechanisms of action that might explain the nutrient partitioning effect of betaine and conjugated linoleic acid (CLA) in Iberian pigs and to address potential adverse effects, twenty gilts were restrictively fed from 20 to 50 kg BW Control, 0.5% betaine, 1% CLA or 0.5% betaine 1 1% CLA diets. Serum hormones and metabolites profile were determined at 30 kg BW and an oral glucose test was performed before slaughter. Pigs were slaughtered at 50 kg BW and livers were obtained for chemical and histological analysis. Decreased serum urea in pigs fed betaine and betaine 1 CLA diets (11%; P 5 0.0001) indicated a more efficient N utilization. The increase in serum triacylglycerol (58% and 28%, respectively; P 5 0.0098) indicated that CLA and betaine 1 CLA could have reduced adipose tissue triacylglycerol synthesis from preformed fatty acids. Serum glucose, lowdensity lipoprotein (LDL) cholesterol and non-esterified fatty acids were unaffected. CLA and betaine 1 CLA altered serum lipids profile, although liver of pigs fed CLA diet presented no histopathological changes and triglyceride content was not different from Control pigs. Compared with controls, serum growth hormone decreased (20% to 23%; P 5 0.0209) for all treatments. Although serum insulin increased in CLA, and especially in betaine 1 CLA pigs (28% and 83%; P 5 0.0001), indices of insulin resistance were unaffected. In conclusion, CLA, and especially betaine 1 CLA, induced changes in biochemical parameters and hormones that may partially explain a nutrient partitioning effect in young pigs. Nevertheless, they exhibited weak, although detrimental, effects on blood lipids. Moreover, although livers were chemically and histologically normal, pigs fed CLA diet challenged with a glucose load had higher serum glucose than controls.

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Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats

Cited by 36 publications

References 24 publications

Conjugated Linoleic Acid Impairs Endothelial Function

Conjugated Linoleic Acid Impairs Endothelial Function

Influence of dietary conjugated linoleic acid on growth, meat quality, lipogenesis, plasma leptin and physiological variables of lipid metabolism in rabbits1

Impact of dietary betaine and conjugated linoleic acid on insulin sensitivity, protein and fat metabolism of obese pigs

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