Acute Recurrent Pancreatitis and COVID-19 Infection: A Case Report with Literature Review

Sandhu, Harindra; Mallik, Dhiraj; Lokavarapu, Manoj Joshua; Huda, Farhanul; Basu, Somprakas

doi:10.7759/cureus.13490

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…SARS-CoV-2 has been isolated from pancreatic specimens during autopsies of infected patients [ 28 ]. It is entirely plausible that other causes (alcohol, gallstones) might have been implicated here, but the association between COVID-19 and acute pancreatitis is difficult to ignore as many case reports have suggested an association between COVID-19 and acute pancreatitis [ 6 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Independent Predictors and Causes of Thirty-Day Gastrointestinal Readmissions Following COVID-19-Related Hospitalizations: Analysis of the National Readmission Database

Kwei-Nsoro,

Attar,

Shaka

et al. 2023

Gastroenterol Res

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Background The coronavirus disease 2019 (COVID-19) pandemic led to significant mortality and morbidity in the United States. The burden of COVID-19 was not limited to the respiratory tract alone but had significant extrapulmonary manifestations. We decided to examine the causes, predictors, and outcomes of gastrointestinal (GI)-related causes of 30-day readmission following index COVID-19 hospitalization. Methods We used the National Readmission Database (NRD) from 2020 to identify hospitalizations among adults with principal diagnosis of COVID-19. We identified GI-related hospitalizations within 30 days of index admission after excluding elective and traumatic admissions. We identified the top causes of GI-related readmission, and the outcomes of these hospitalizations. We used a multivariate Cox regression analysis to identify the independent predictors of readmission. Results Among 1,024,492 index hospitalizations with a primary diagnosis of COVID-19 in the 2020 NRD database, 644,903 were included in the 30-day readmission study. Of these 3,276 (0.5%) were readmitted in 30 days due to primary GI causes. The top five causes of readmissions we identified in this study were GI bleeding, intestinal obstruction, acute diverticulitis, acute pancreatitis, and acute cholecystitis. Multivariate Cox regression analysis done adjusting for confounders showed that renal failure, alcohol abuse, and peptic ulcer disease were associated with increased odds of 30-day readmission from GI-related causes. Conclusions GI manifestations of COVID-19 are not uncommon and remain an important cause of readmission. Targeted interventions addressing the modifiable predictors of readmission identified will be beneficial in reducing the burden on already limited healthcare resources.

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Section: Discussionmentioning

confidence: 99%

Independent Predictors and Causes of Thirty-Day Gastrointestinal Readmissions Following COVID-19-Related Hospitalizations: Analysis of the National Readmission Database

Kwei-Nsoro,

Attar,

Shaka

et al. 2023

Gastroenterol Res

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“…The most common risk factors for acute pancreatitis are gallbladder disease (often caused by choledocholithiasis) and chronic alcohol consumption. Acute pancreatitis is defi ned as the presence of typical pancreatic abdominal pain, an increase in serum amylase/lipase more than three times of regular value, and ultrasound, CT, or MRI imaging fi ndings support the diagnosis [19][20][21] .…”

Section: Discussionmentioning

confidence: 99%

Manifestations of Acute Pancreatitis in Severe COVID-19 Patients: Is This a Coincidence?

Romadhon

Suryantoro²,

Windradi³

et al. 2021

IJTID

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Coronavirus Disease-19 (COVID-19) adalah penyakit yang disebabkan oleh Severe Acute Acute Respiratory Coronavirus-2 (SARS-CoV2) yang berasal dari China, menyebar dengan cepat ke seluruh bagian negara lain yang menyebabkan pandemi dunia. Dengan derajat gejala yang bervariasi yang disebabkan oleh COVID-19, virus ini menyebabkan kerusakan pada beberapa organ, baik karena efek inﬂ amasi tidak langsung maupun efek sitopatik. Data terkait keterlibatan pankreas dalam kasus COVID-19 masih belum jelas. Seorang laki-laki usia 83 tahun dirawat karena gejala COVID-19 berat. Dalam perawatan, pasien memberikan gejala dan tanda pankreatitis akut tanpa diketahui faktor resiko yang terkait. Pada pemeriksaan didapatkan RT-PCR SARS-CoV2 positif dari swab nasofaring, amilase lipase yang meningkat serta gambaran ultrasound khas untuk pankreatitis akut. Tatalaksana pasien tetap berdasar pada kasus SARS-CoV2 dengan isolasi, oksigenasi, pemberian anti virus dan suportif. Pemberian antibiotik juga didasarkan pada terapi empiris yang kemudian disesuaikan hasil sensitiﬁ tas kultur. Skor prognosis pankreatitis menunjukkan risiko kematian pada kasus moderate. Pada perjalanan, pasien meninggal karena shock sepsis. Prevalensi pankreatitis akut dan tingkat keparahannya perlu diamati. Dalam artikel ini, kami menyajikan kasus pankreatitis akut yang terjadi pada COVID-19 parah dengan faktor risiko yang tidak diketahui.Diagnosis penyebab kasus pankreatitis masih belum jelas tetapi beberapa bukti autopsi kasus infeksi SARS-CoV2 dengan pankreatitis menyebutkan bahwa infeksi virus ini dapat menyebabkan injuri pada pankreas.. Kondisi sepsis dapat diakibatkan infeksi virus SARS-CoV2 (viral sepsis) atau ko-infeksi bakteri. Oleh karena itu, rasionalisasi penggunaan antibiotik juga diperlukan. Kasus ini merupakan kasus yang membutuhkan managemen holisitik dan intensif karena kedua kondisi berpotensi dapat memperberat satu sama lain. Pengenalan awal kegawatan serta terapi tepat merupakan hal yang penting dapat menunjang kesintasan pasien.

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“… 3 In published literature, numerous cases of COVID-19 complicated with AP have been reported ( Table 1 ). 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 However, no robust causative relationship has been established between them.…”

Section: Introductionmentioning

confidence: 99%

Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

Tang

Gao

Tong

et al. 2022

The American Journal of the Medical Sciences

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Acute Recurrent Pancreatitis and COVID-19 Infection: A Case Report with Literature Review

Cited by 8 publications

References 10 publications

Independent Predictors and Causes of Thirty-Day Gastrointestinal Readmissions Following COVID-19-Related Hospitalizations: Analysis of the National Readmission Database

Independent Predictors and Causes of Thirty-Day Gastrointestinal Readmissions Following COVID-19-Related Hospitalizations: Analysis of the National Readmission Database

Manifestations of Acute Pancreatitis in Severe COVID-19 Patients: Is This a Coincidence?

Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

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