Acute Reboxetine Administration Increases Plasma and Salivary Cortisol

Hill, SA; Taylor, Matthew; Harmer, Catherine J.; Cowen, Philip J.

doi:10.1177/02698811030173008

Cited by 17 publications

(16 citation statements)

References 10 publications

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“…Related catecholaminergic substances, such as amphetamine and methamphetamine, have also been shown to elevate cortisol levels in some studies [33,34,35,36] but not others [14]. A single dose of the NET inhibitor reboxetine also increased cortisol levels [37], particularly in subjects who scored high on subclinical depression [38]. Chronic treatment with methylphenidate increased the levels of DHEA and DHEAS but not cortisol in children with attention-deficit/hyperactivity disorder [39].…”

Section: Discussionmentioning

confidence: 99%

Acute Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate on Circulating Steroid Levels in Healthy Subjects

et al. 2014

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3,4-Methylenedioxymethamphetamine (MDMA, ‘ecstasy') and methylphenidate are widely used psychoactive substances. MDMA primarily enhances serotonergic neurotransmission, and methylphenidate increases dopamine but has no serotonergic effects. Both drugs also increase norepinephrine, resulting in sympathomimetic properties. Here we studied the effects of MDMA and methylphenidate on 24-hour plasma steroid profiles. 16 healthy subjects (8 men, 8 women) were treated with single doses of MDMA (125 mg), methylphenidate (60 mg), MDMA + methylphenidate, and placebo on 4 separate days using a cross-over study design. Cortisol, cortisone, corticosterone, 11-dehydrocorticosterone, aldosterone, 11-deoxycorticosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androstenedione, and testosterone were repeatedly measured up to 24 h using liquid chromatography-tandem mass spectroscopy. MDMA significantly increased the plasma concentrations of cortisol, corticosterone, 11-dehydrocorticosterone, and 11-deoxycorticosterone and also tended to moderately increase aldosterone levels compared with placebo. MDMA also increased the sum of cortisol + cortisone and the cortisol/cortisone ratio, consistent with an increase in glucocorticoid production. MDMA did not alter the levels of cortisone, DHEA, DHEAS, androstenedione, or testosterone. Methylphenidate did not affect any of the steroid concentrations, and it did not change the effects of MDMA on circulating steroids. In summary, the serotonin releaser MDMA has acute effects on circulating steroids. These effects are not observed after stimulation of the dopamine and norepinephrine systems with methylphenidate. The present findings support the view that serotonin rather than dopamine and norepinephrine mediates the acute pharmacologically induced stimulation of the hypothalamic-pituitary-adrenal axis in the absence of other stressors.

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Section: Discussionmentioning

confidence: 99%

Acute Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate on Circulating Steroid Levels in Healthy Subjects

et al. 2014

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“…In contrast, salivary cortisol responses to dexamethasone show a large variability (Reynolds et al 1998). Moreover, salivary cortisol is a non-invasive procedure, and it has been successfully used to test HPA axis activity in large samples of patients with psychiatric disorders as well as of healthy controls (Pariante et al 2002(Pariante et al , 2004aBhagwagar et al 2002Bhagwagar et al , 2003Bhagwagar et al , 2005Harmer et al 2003;Hill et al 2003;Portella et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Different responses to dexamethasone and prednisolone in the same depressed patients

et al. 2006

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“…Noradrenaline is thought to augment HPA axis function by increasing corticotrophin releasing hormone (CRF) at the paraventricular nucleus of the hypothalamus (Plotsky, 1987;Curtis et al, 2002;Hill et al, 2003). As such, it has been proposed that neuroendocrine challenge using noradrenergic drugs may represent a useful method for probing the functional integrity of central noradrenergic pathways (Hill et al, 2003). Salivary cortisol sampling has been developed as a simple non-invasive convenient proxy marker of central HPA axis function, and has been shown to be sensitive to noradrenergic manipulation with reboxetine (Hill et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Atomoxetine increases salivary cortisol in healthy volunteers

et al. 2007

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It has been proposed that acute hypothalamo-pituitary-adrenal (HPA) axis challenge using noradrenergic drugs may be of utility in assessing the functional integrity of central noradrenaline pathways. Atomoxetine (formerly tomoxetine) is a highly selective noradrenaline reuptake inhibitor, which has recently been licensed for the treatment of attention deficit hyperactivity disorder (ADHD). The aim of this study was to assess the effects of acute atomoxetine on salivary cortisol levels for the first time.A total of 60 healthy male volunteers received 60 mg atomoxetine, 30 mg citalopram, or placebo per os in a double-blind parallel groups design (n = 20 per group). Salivary cortisol, blood pressure and pulse rates were recorded at baseline and at +1.0, +1.5, +2.5 and +3.5 hours after capsule administration.60 mg atomoxetine led to highly significant increases in salivary cortisol and a moderate increase in pulse rate, in the absence of significant effects on blood pressure. 30 mg citalopram had no significant effects on cortisol or cardiovascular parameters. These data support the utility of atomoxetine neuroendocrine challenge for evaluating central noradrenaline pathways, which may be of future use in neuropsychiatric patient studies. Furthermore, the effects of atomoxetine on HPA axis function may have clinical implications given the use of this agent in the treatment of ADHD.

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Acute Reboxetine Administration Increases Plasma and Salivary Cortisol

Cited by 17 publications

References 10 publications

Acute Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate on Circulating Steroid Levels in Healthy Subjects

Acute Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate on Circulating Steroid Levels in Healthy Subjects

Different responses to dexamethasone and prednisolone in the same depressed patients

Atomoxetine increases salivary cortisol in healthy volunteers

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