Acute radiation-induced pulmonary damage: A clinical study on the response to fractionated radiation therapy

Mah, Kandice; Dyk, Jake ban; Keane, Tom; Pooh, Peter Y.

doi:10.1016/0360-3016(87)90125-8

Cited by 180 publications

(55 citation statements)

References 29 publications

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“…As delivery of new inhalation gene therapy vectors becomes feasible, 25 use of radioprotective gene therapy programs in fractionated radiotherapy of thoracic tumor volumes or in total body irradiation patients 3 may become practical for reducing side-effects, including those mediated by lung tissue radiation damage. [26][27][28][29] Gene Therapy…”

Section: Discussionmentioning

confidence: 99%

Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation

et al. 2000

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To determine whether intratracheal (IT) lung protective manganese superoxide-plasmid/liposomes (MnSOD-PL) complex provided 'bystander' protection of thoracic tumors, mice with orthotopic Lewis lung carcinoma-bacterial ␤-galactosidase gene (3LL-LacZ) were studied. There was no significant difference in irradiation survival of 3LL-LacZ cells irradiated, then cocultured with MnSOD-PL-treated compared with control lung cells (D 0 2.022 and 2.153, respectively), or when irradiation was delivered 24 h after coculture (D 0 0.934 and 0.907, respectively). Tumor-bearing control mice showed 50% survival at 18 days and 10% survival at 21 days. Mice receiving liposomes with no insert or LacZ-PL complex plus 18 Gy had 50% survival at 22 days,

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Section: Discussionmentioning

confidence: 99%

Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation

et al. 2000

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“…In the past years several authors have addressed the problem of radiation-induced lung damage in breast cancer patients (1)(2)(3)(4)(5)(6). Though most of the patients do not suffer from clinical side-effects from the lungs after standard radiotherapy, cough and dyspnoe are known to cause major distress among patients suffering from radiationinduced pneumonitis.…”

mentioning

confidence: 99%

Influence of Radiation Therapy on Lung Tissue in Breast Cancer Patients: CT-assessed density changes 4 years after completion of radiotherapy

1995

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“…Organs at risk for RT toxicity include lungs, heart and esophagus. CT density in irradiated lung is correlated with cough and shortness of breath and other manifestation of radiation pneumonitis (105,106). MRI has also been shown to detect radiation pneumonitis by measuring lung density (107) and detecting unbalanced enhancement of the lung (108).…”

Section: Imaging Of Organs At Risk During Treatmentmentioning

confidence: 99%

Anatomic, functional and molecular imaging in lung cancer precision radiation therapy: treatment response assessment and radiation therapy personalization

MacManus

Everitt

Schimek-Jasch

et al. 2017

Transl. Lung Cancer Res.

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This article reviews key imaging modalities for lung cancer patients treated with radiation therapy (RT) and considers their actual or potential contributions to critical decision-making. An international group of researchers with expertise in imaging in lung cancer patients treated with RT considered the relevant literature on modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET). These perspectives were coordinated to summarize the current status of imaging in lung cancer and flag developments with future implications.Although there are no useful randomized trials of different imaging modalities in lung cancer, multiple prospective studies indicate that management decisions are frequently impacted by the use of complementary imaging modalities, leading both to more appropriate treatments and better outcomes. This is especially true of 18 F-fluoro-deoxyglucose (FDG)-PET/CT which is widely accepted to be the standard imaging modality for staging of lung cancer patients, for selection for potentially curative RT and for treatment planning. PET is also more accurate than CT for predicting survival after RT. PET imaging during RT is also correlated with survival and makes response-adapted therapies possible. PET tracers other than FDG have potential for imaging important biological process in tumors, including hypoxia and proliferation. MRI has superior accuracy in soft tissue imaging and the MRI Linac is a rapidly developing technology with great potential for online monitoring and modification of treatment. The role of imaging in RT-treated lung cancer patients is evolving rapidly and will allow increasing personalization of therapy according to the biology of both the tumor and dose limiting normal tissues.

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Acute radiation-induced pulmonary damage: A clinical study on the response to fractionated radiation therapy

Cited by 180 publications

References 29 publications

Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation

Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation

Influence of Radiation Therapy on Lung Tissue in Breast Cancer Patients: CT-assessed density changes 4 years after completion of radiotherapy

Anatomic, functional and molecular imaging in lung cancer precision radiation therapy: treatment response assessment and radiation therapy personalization

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