Acute Q fever pneumonia: high-resolution computed tomographic findings in six patients

Ranke, Felipe Mussi von; Pessôa, Fernanda Miraldi Clemente; Afonso, Felipe; Gomes, Josiani Bastos; Borghi, Danielle Provençano; Melo, Alessandro Severo Alves de; Marchiori, Edson

doi:10.1259/bjr.20180292

Cited by 10 publications

(6 citation statements)

References 18 publications

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“…Apart from slaughterhouse scenarios, human Q fever in Brazil has been confirmed in patients with endocarditis [ 31 – 33 ], patients suspected of having dengue [ 34 , 35 ], and a family cluster case [ 36 ]. Additionally, the most recently reported case of Q fever involved six cadets after a military training where they had contact with a goat and capybaras [ 37 , 38 ]. The state of Rio de Janeiro is the region of Brazil with the most reports of Q fever.…”

Section: Introductionmentioning

confidence: 99%

Coxiella burnetii in slaughterhouses in Brazil: A public health concern

et al. 2020

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Q fever is an important zoonosis, yet it is often neglected and can present large outbreaks, as observed in the Netherlands. In the past few years, cases of Q fever have been described in Brazil; however, the epidemiological situation of Q fever in ruminants, the main reservoir of the pathogen, is unknown in this country. Our study aimed to estimate the prevalence of C . burnetii in cattle sent to slaughterhouses using an immunofluorescence assay (IFA) and quantitative real-time PCR (qPCR). From 1515 cattle serum samples collected from nine slaughterhouses, 23.8% (360/1515) were serologically positive by IFA (cutoff titer>1:64), indicating past or recent exposure to C . burnetii infection. Among the 54 cities sampled during the study, 83.3% (45/54) had at least one seropositive animal. Subsequently, all seropositive samples were submitted to qPCR for C . burnetii DNA, and 12.2% (44/360) of the sera were qPCR positive, which indicates bacteremia and suggests active or recent infection. The results highlight the risk for abattoir workers that results from exposure to contaminated aerosols produced during slaughter procedures. Moreover, the heat maps that were construction from the positive samples demonstrate the widespread distribution of C . burnetii in the State of São Paulo, Brazil and denotes the need for surveillance and preventive measures to reduce the prevalence in cattle.

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Section: Introductionmentioning

confidence: 99%

Coxiella burnetii in slaughterhouses in Brazil: A public health concern

et al. 2020

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“…As a result, Q fever is often misdiagnosed as influenza or common pneumonia. 1,16 In the case presented, the patient remained high fever after admission, and the disease continued to progress despite the empirical anti-infective treatment. Laboratory examination suggested an acute infection, impaired liver function, abnormal coagulation function, thrombocytopenia, negative blood culture, and an undetermined the etiology of infection.…”

Section: Discussionmentioning

confidence: 88%

Diagnosis of Acute Q Fever in a Patient by Using Metagenomic Next-Generation Sequencing: A Case Report

Wang¹,

Zhang²,

Cai³

et al. 2023

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Background Q fever is a zoonotic disease caused by Coxiella burnetii infection, with domestic ruminants as the main source of infection and tick bites as one of the transmission vectors. The clinical manifestations of Q fever are varied and atypical. For the reason that C. burnetii is a strictly intracellular pathogen, it is difficult to be diagnosed by traditional culture methods. Additionally, serological and molecular diagnostic methods to assist in the diagnosis of Q fever are not routinely performed in most clinical laboratories. Therefore, early and rapid diagnosis of Q fever is a challenge. Case Presentation In the present study, a 34-year-old male patient presented with an acute onset and symptoms such as high fever, lethargy, pulmonary infection, and liver damage. In addition, he had a history of tick bites. Despite conducting relevant laboratory and radiological examinations, the etiology remained unknown. Subsequently, we detected the sequence reads of C. burnetii in a venous blood sample using metagenomic next-generation sequencing (mNGS), and the symptoms of patients were significantly improved after timely treatment with the special drug tetracycline. To our knowledge, this is the first report of Q fever associated with C. burnetii detected directly from venous blood sample in Wuhan, China. Conclusion Metagenomic next-generation sequencing is a new diagnostic technology that provides rapid and accurate detection of unexplained infections, including Q fever. Its application plays a crucial role in clinical diagnosis for identifying elusive pathogens.

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“…Two years later, still in the Rio de Janeiro state, Lemos et al described a cluster of Q fever among cadets with history of camping during military survival training where they participated in the slaughtering animals for their own consumption. Seroconversion was identified in all patients and Cb DNA was detected in bronchoalveolar lavage from one of the five cadets who had pneumonia with acute respiratory distress syndrome [ 39 •, 40 ]. Previous prevalence studies in specific populations were carried out using immunofluorescence assays that showed a prevalence of 3.2% of Cb antibodies (4/125) in human immunodeficiency virus–positive patients and 9.3% (28/300) in individuals who injected drugs [ 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Human Q Fever on the Guiana Shield and Brazil: Recent Findings and Remaining Questions

et al. 2021

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Purpose of Review In this review, we report on the state of knowledge about human Q fever in Brazil and on the Guiana Shield, an Amazonian region located in northeastern South America. There is a contrast between French Guiana, where the incidence of this disease is the highest in the world, and other countries where this disease is practically non-existent. Recent Findings Recent findings are essentially in French Guiana where a unique strain MST17 has been identified; it is probably more virulent than those usually found with a particularly marked pulmonary tropism, a mysterious animal reservoir, a geographical distribution that raises questions. Summary Q fever is a bacterial zoonosis due to Coxiella burnetii that has been reported worldwide. On the Guiana Shield, a region mostly covered by Amazonian forest, which encompasses the Venezuelan State of Bolivar, Guyana, Suriname, French Guiana, and the Brazilian State of Amapá, the situation is very heterogeneous. While French Guiana is the region reporting the highest incidence of this disease in the world, with a single infecting clone (MST 117) and a unique epidemiological cycle, it has hardly ever been reported in other countries in the region. This absence of cases raises many questions and is probably due to massive under-diagnosis. Studies should estimate comprehensively the true burden of this disease in the region.

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Acute Q fever pneumonia: high-resolution computed tomographic findings in six patients

Cited by 10 publications

References 18 publications

Coxiella burnetii in slaughterhouses in Brazil: A public health concern

Coxiella burnetii in slaughterhouses in Brazil: A public health concern

Diagnosis of Acute Q Fever in a Patient by Using Metagenomic Next-Generation Sequencing: A Case Report

Human Q Fever on the Guiana Shield and Brazil: Recent Findings and Remaining Questions

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