Acute pulmonary toxicity following occupational exposure to a floor stain protector in the building industry in Switzerland

Lazor-Blanchet, Catherine; Rusca, Sophie; Vernez, David; Berry, R. A.; Albrecht, Éric; Droz, Pierre‐Olivier; Boillat, Marcel-André

doi:10.1007/s00420-004-0505-6

Cited by 33 publications

(23 citation statements)

References 16 publications

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“…First, the fluoropolymer may act as a carrier molecule allowing the hydrocarbon solvent to deeply penetrate alveoli [3]. Second, because of increased solvent volatility, the size of aerosol particles decreases more rapidly, resulting in increased inhalation and increased number of particles reaching the alveoli [7]. Third, the fluoropolymer resin may interact with type II alveolar cells and surfactant, generating acute lung injury [13].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary toxicity following exposure to waterproofing grout sealer

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Pulmonary toxicity following exposure to waterproofing grout sealer

et al. 2009

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“…An In Vitro Method for Predicting Inhalation Toxicity of Impregnation Spray Products Jorid B. Sørli 1 al., 1995;Lazor-Blanchet et al, 2004;Vernez et al, 2006). The potential health risk of impregnation products is well known, but pinpointing the causative agent that makes a product hazardous has proven difficult.…”

Section: Research Articlementioning

confidence: 99%

“…The symptoms often develop within minutes to a few hours after exposure and include coughing, shortness of breath and chest pain (Burkhart et al, 1996; Centers for Disease Control and Prevention, 1993). The symptoms spontaneously resolve within a few days, but sometimes supportive treatment with oxygen, bronchodilators or corticosteroids is needed (Burkhart et al, 1996;Laliberte et al, 1995;Lazor-Blanchet et al, 2004). Permanent effects after exposure are rare, but have been reported (Wallace and Brown, 2005).…”

Section: Introductionmentioning

confidence: 99%

An in vitro method for predicting inhalation toxicity of impregnation spray products

Sørli

Hansen

Nørgaard

et al. 2015

ALTEX

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“…Three occupational cases following the use of a stain-repellent resin on stone-tiled walls and floors were also reported. (15) The exposure conditions of these three cases were investigated in a previous study. (16) Emission measurements and simulations indicated that: (1) significant aerosol and solvent concentrations may occur during waterproofing, and (2) the amounts of solvent and particles in the workers' breathing zone were lower with the new resin formulation.…”

Section: Introductionmentioning

confidence: 99%

Acute Respiratory Syndrome After Inhalation of Waterproofing Sprays: A Posteriori Exposure-Response Assessment in 102 Cases

Vernez¹,

Bruzzi²,

Kupferschmidt³

et al. 2006

Journal of Occupational and Environmental Hygiene

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Waterproofing agents are widely used to protect leather and textiles in both domestic and occupational activities. An outbreak of acute respiratory syndrome following exposure to waterproofing sprays occurred during the winter 2002-2003 in Switzerland. About 180 cases were reported by the Swiss Toxicological Information Centre between October 2002 and March 2003, whereas fewer than 10 cases per year had been recorded previously. The reported cases involved three brands of sprays containing a common waterproofing mixture, that had undergone a formulation change in the months preceding the outbreak. A retrospective analysis was undertaken in collaboration with the Swiss Toxicological Information Centre and the Swiss Registries for Interstitial and Orphan Lung Diseases to clarify the circumstances and possible causes of the observed health effects. Individual exposure data were generated with questionnaires and experimental emission measurements. The collected data was used to conduct numeric simulation for 102 cases of exposure. A classical two-zone model was used to assess the aerosol dispersion in the near- and far-field during spraying. The resulting assessed dose and exposure levels obtained were spread on large scales, of several orders of magnitude. No dose-response relationship was found between exposure indicators and health effects indicators (perceived severity and clinical indicators). Weak relationships were found between unspecific inflammatory response indicators (leukocytes, C-reactive protein) and the maximal exposure concentration. The results obtained disclose a high interindividual response variability and suggest that some indirect mechanism(s) predominates in the respiratory disease occurrence. Furthermore, no threshold could be found to define a safe level of exposure. These findings suggest that the improvement of environmental exposure conditions during spraying alone does not constitute a sufficient measure to prevent future outbreaks of waterproofing spray toxicity. More efficient preventive measures are needed prior to the marketing and distribution of new waterproofing agents.

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Acute pulmonary toxicity following occupational exposure to a floor stain protector in the building industry in Switzerland

Abstract: Tilers should be warned against spraying floor stain repellents; there is also a need to make consumers aware that the spraying of waterproofing agents in a closed environment and concomitant smoking should be avoided.

Cited by 33 publications

References 16 publications

Pulmonary toxicity following exposure to waterproofing grout sealer

Pulmonary toxicity following exposure to waterproofing grout sealer

An in vitro method for predicting inhalation toxicity of impregnation spray products

Acute Respiratory Syndrome After Inhalation of Waterproofing Sprays: A Posteriori Exposure-Response Assessment in 102 Cases

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