Acute Pulmonary Embolism in Patients with COVID-19 at CT Angiography                     and Relationship to <scp>d</scp>-Dimer Levels

Léonard-Lorant, Ian; Delabranche, Xavier; Séverac, François; Helms, Julie; Pauzet, Coralie; Collange, Olivier; Schneider, Francis; Labani, Aïssam; Bilbault, Pascal; Molière, Sébastien; Leyendecker, Pierre; Roy, Catherine; Ohana, Mickaël

doi:10.1148/radiol.2020201561

Cited by 567 publications

(702 citation statements)

References 8 publications

(5 reference statements)

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“…In patients with non-Covid-19 infection-associated ARDS, 2.1% experienced a PE. The investigators also reported that patients with Covid-19-associated ARDS did not develop DIC and had markedly elevated circulating levels of Von Willebrand factor (VWF) antigen, VWF activity and factor VIII [5].…”

Section: Venous and Arterial Thrombosis In Covid-19 Infectionmentioning

confidence: 98%

COVID-19 update: Covid-19-associated coagulopathy

Becker

2020

J Thromb Thrombolysis

583

646

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We are too much accustomed to attribute to a single cause that which is the product of several, and the majority of our controversies come from that. Marcus AureliusThe Covid-19 pandemic has introduced an array of organspecific and systemic phenotypes-some previously observed in viral infections, including severe acute respiratory syndrome (SARS) and others that appear to be unique to SARScoronavirus (CoV)-2. Rapidly emerging information from clinical observations, autopsy-based findings, extrapolations from in vitro and ex vivo studies and dynamic modeling are informing management guidelines; however, many questions remain unanswered and clinical trials that are required to provide evidence have not been completed in most areas. Among the many questions that require careful thought, reflection and investigation are the mechanism(s) underlying the development of a systemic coagulopathy and acquired thrombophilia characterized in a majority of cases by a proclivity for venous, arterial and microvascular thrombosis.The following review summarizes emerging insights into the pathobiology, mechanism(s), diagnosis, management, foundations for research and either planned or ongoing clinical trials for Covid-19-associated coagulopathy.

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Section: Venous and Arterial Thrombosis In Covid-19 Infectionmentioning

confidence: 98%

COVID-19 update: Covid-19-associated coagulopathy

Becker

2020

J Thromb Thrombolysis

583

646

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“…Acute pulmonary embolism, reported in COVID-19 patients [20,[220][221][222], has been shown to be a cause of clinical deterioration in viral pneumonias [205,223]. Endothelial dysfunction is known to be a key determinant in hypertension, thrombosis, and DIC [72,[224][225][226][227].…”

Section: Thromboembolism and Covid-19mentioning

confidence: 99%

Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

Sardu

Gambardella

Morelli

et al. 2020

JCM

445

436

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The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations.

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“…Data about pulmonary embolism being more frequent in patients with COVID-19 [11] may lead to widespread use of intravenous contrast in post-operative settings, a period that is already at higher risk of thromboembolic events.…”

Section: Covid-19 and Recent Operations 419mentioning

confidence: 99%

COVID-19 in Post-Operative Patients: Imaging Findings

Molière

Veillon

2020

Surgical Infections

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Background: Coronavirus 2019 in the post-operative period is challenging. Its clinical manifestations may have similarities to other septic, thoracic, or gastrointestinal post-surgical complications. Additionally, the post-operative period may be a time of increased risk for severe manifestations of COVID-19. We sought to evaluate the frequency of COVID-19 in a cohort of patients who had recently had operations who were undergoing imaging for acute symptoms and the role of chest computed tomography (CT) in this setting. Patients and Methods:We included all patients who had chest CT for acute symptoms in the 15 days after a surgical procedure between March 1 and 31, 2020. Results: Of 46 patients with acute post-operative symptoms requiring chest imaging, eight (17%) were ultimately diagnosed with COVID-19. Among them, five (62%) required mechanical ventilation and two (25%) died. All had abnormal chest CT with typical findings of COVID-19 in 87%. Computed tomography provided an alternate diagnosis in 53% of patients who did not have COVID-19. The average time between a COVID-19-positive chest CT and the polymerase chain reaction (PCR) confirmation was 1.2 days (range, 0-4 days).

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Acute Pulmonary Embolism in Patients with COVID-19 at CT Angiography and Relationship to d-Dimer Levels

Abstract: statement Thirty-two of 106 (30%, [95%CI 22-40%]) patients with COVID-19 infection were positive for acute pulmonary embolus on pulmonary CT angiograms.

Cited by 567 publications

References 8 publications

COVID-19 update: Covid-19-associated coagulopathy

COVID-19 update: Covid-19-associated coagulopathy

Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

COVID-19 in Post-Operative Patients: Imaging Findings

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