Acute pulmonary embolism and COVID-19 pneumonia: a random association?

Danzi, Gian Battista; Loffi, Marco; Galeazzi, Gianluca; Gherbesi, Elisa

doi:10.1093/eurheartj/ehaa254

Cited by 595 publications

(593 citation statements)

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“…Xie et al [49] reported occurrence of acute pulmonary embolism in two patients aged 57 and 70 years with elevated D-dimer and multiple filling defects on CT pulmonary angiogram. Similarly, Danzi et al [50] too reported a 75-year-old female with pulmonary embolism and TTE finding of right ventricular dysfunction. Multiple studies from China have reported higher D-dimer levels in COVID-19 patients with adverse outcomes.…”

Section: Venous Thrombo-embolismmentioning

confidence: 81%

Cardiovascular system and COVID-19: perspectives from a developing country

Kunal

Gupta

Sharma

et al. 2020

Monaldi Arch Chest Dis

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A novel coronavirus, SARS-CoV-2, thought to have originated from bats causes COVID-19 infection which was first reported from Wuhan, China in December 2019. This virus has a high infectivity rate and has impacted a significant chunk of the population worldwide. The spectrum of disease ranges from mild to severe with respiratory system being the most commonly affected. Cardiovascular system often gets involved in later stages of the disease with acute cardiac injury, heart failure and arrhythmias being the common complications. In addition, the presence of cardiovascular co-morbidities such as hypertension, coronary artery disease in these patients are often associated with poor prognosis. It is still not clear regarding the exact mechanism explaining cardiovascular system involvement in COVID-19. Multiple theories have been put forward however, more robust studies are required to fully elucidate the “heart and virus” link. The disease has already made its presence felt on the global stage and its impact in the developing countries is going to be profound. These nations not only have a poorly developed healthcare system but there is also a huge burden of cardiovascular diseases. As a result, COVID-19 would adversely impact the already overburdened healthcare network leading to impaired cardiovascular care delivery especially for acute coronary syndrome and heart failure patients.

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Section: Venous Thrombo-embolismmentioning

confidence: 81%

Cardiovascular system and COVID-19: perspectives from a developing country

Kunal

Gupta

Sharma

et al. 2020

Monaldi Arch Chest Dis

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“…Acute pulmonary embolism, reported in COVID-19 patients [20,[220][221][222], has been shown to be a cause of clinical deterioration in viral pneumonias [205,223]. Endothelial dysfunction is known to be a key determinant in hypertension, thrombosis, and DIC [72,[224][225][226][227].…”

Section: Thromboembolism and Covid-19mentioning

confidence: 99%

Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

Sardu

Gambardella

Morelli

et al. 2020

JCM

463

436

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The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations.

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“…There are recent concerns that COVID-19 patients harbor a high rate of pulmonary embolism that are missed due to primary lung injury from the virus (25). These patients are clinically too unstable to transport for imaging for definitive care.…”

mentioning

confidence: 99%