Acute pulmonary edema secondary to hyperbaric oxygen therapy

Obiagwu, Chukwudi; Paul, Vishesh; Chadha, Sameer; Hollander, Gerald; Shani, Jacob

doi:10.1093/omcr/omv002

Cited by 15 publications

(11 citation statements)

References 4 publications

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“…In the lungs, bleeding, inflammation and emphysema can occur during exposure to excessive HBOT. In hyperbaric medicine, these changes are called pulmonary barotraumas and initially manifest as tracheobronchitis (transient with cessation of exposure), which, with continued exposure, progresses to acute respiratory distress syndrome and, finally, interstitial pulmonary fibrosis (Obiagwu et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

Hyperbaric oxygen therapy in wound healing in mice

Amaral

Krause

Pasini

et al. 2021

Arq. Bras. Med. Vet. Zootec.

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We investigated the local and systemic effects of hyperbaric oxygen therapy in BALB/C mice, exposed to two different exposure times, under 2.4 atmosphere (ATM). Fifteen animals were divided into three groups (GI, GII and Control) and underwent a surgical excision of a skin fragment of approximately one square centimeter of the dorsal region. The wounds were treated and monitored for 21 days. In the control group, the wound was cleaned once a day with sterile 0.9% NaCl solution. GI and GII mice were submitted to daily hyperbaric oxygen therapy of 30 or 60minutes sessions, respectively. The wounds were photographed every three days and their surfaces were analyzed by an image analyzer. At 21 days, all animals were euthanatized for histopathological analysis of the skin, lungs and liver in order to identify eventual alterations in wound healing or in the analyzed organs. Animals belonging to GI showed a faster skin wound healing in comparison to the other groups. Animals from GII, however, showed a delayed wound healing process and exhibited lung and microcirculatory alterations. These findings allow us to conclude that the exposure time to the oxygen in hyperbaric environment is crucial and can help or disturb skin wound healing or even be deleterious to other organs.

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Section: Resultsmentioning

confidence: 99%

Hyperbaric oxygen therapy in wound healing in mice

Amaral

Krause

Pasini

et al. 2021

Arq. Bras. Med. Vet. Zootec.

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“…There was also a reported case of acute lung edema in an 80 year old patient with ischemic cardiomyopathy (ejection fraction 25%), noninsulin-dependent diabetes mellitus and peripheral vascular disease -which was the indication for HBO therapy. The patient had no clear signs of heart failure prior to HBOT (86). However, his overall hypoxic predisposition, according to the authors, might have been a risk factor for the emergence of acute lung edema during HBOT.…”

Section: Hbot Effects On the Cardiorespiratory System In The Agedmentioning

confidence: 80%

Hyperbaric oxygenation for resuscitation and therapy of elderly patients with cerebral and cardio-respiratory dysfunction

Rogatsky

Stambler

2017

Front Biosci

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Hyperbaric oxygenation therapy (HBOT) has been gaining an increasing recognition as a versatile therapeutic approach. This article reviews the application of hyperbaric oxygenation as a method for resuscitation and therapy of elderly patients with cerebral and cardio-respiratory dysfunction, in acute as compared to chronic impairments. The vital role of proper dosage of HBO therapy to ensure both the efficacy and safety of the treatment is emphasized. We argue that in the acute stages of brain and cardiorespiratory impairment, the adequate hyperbaric oxygen dose is the most important condition for obtaining maximum therapeutic effect, due to the powerful anti-hypoxic capabilities of this method. In contrast, during the chronic course of such impairments, there is an increased importance of safe dosing for the prevention of oxygen intoxication. Further dosage adjustments need to be made for the elderly as compared to younger patients, while examining and taking into consideration long term therapy effects. Some potential geroprotective mechanisms of HBO therapy are considered, that may be analogous to other geroprotective medications.

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“…Two patients were said to have not received HBO 2 T on account of moderate to severe pulmonary hypertension, the underlying reason for this was not discussed. There have been case reports associating HBO 2 T with pulmonary edema in patients with leftsided heart failure [19,20]. Possible mechanisms attributed to this finding include increased peripheral vasoconstriction leading to increased cardiac afterload, increased oxidative myocardial stress, decreased left ventricular (LV) compliance by oxygen radical-mediated reduction in nitric oxide right and left ventricular imbalance, and increased pulmonary capillary permeability.…”

Section: Discussionmentioning

confidence: 99%

Successful Use of Hyperbaric Oxygen as Adjunctive Therapy for a Nonhealing Venous Ulcer in a Patient with Systemic Sclerosis and Pulmonary Arterial Hypertension: A Case Report and Review of the Literature

Biney

Dudney

Goldman

et al. 2020

Case Reports in Pulmonology

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Skin ulcers are a common complication of systemic sclerosis (SSc) that can significantly impact the quality of life. There have been recent reports on the use of hyperbaric oxygen therapy (HBO2T) in the management of nonhealing systemic sclerosis skin ulcers. The effect of HBO2T on pulmonary arterial hypertension (PAH), another common and potentially life-threatening complication of SSc, is unclear with literature on the subject lacking. We present the case of a 65-year-old female with limited SSc complicated by severe PAH and a nonhealing left lower extremity venous ulcer. HBO2T was successfully used as an adjunct in her management resulting in complete resolution of the venous ulcer and improved quality of life without any adverse effects on her pulmonary arterial hypertension.

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Acute pulmonary edema secondary to hyperbaric oxygen therapy

Cited by 15 publications

References 4 publications

Hyperbaric oxygen therapy in wound healing in mice

Hyperbaric oxygen therapy in wound healing in mice

Hyperbaric oxygenation for resuscitation and therapy of elderly patients with cerebral and cardio-respiratory dysfunction

Successful Use of Hyperbaric Oxygen as Adjunctive Therapy for a Nonhealing Venous Ulcer in a Patient with Systemic Sclerosis and Pulmonary Arterial Hypertension: A Case Report and Review of the Literature

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