Acute Pulmonary Edema in Healthy Teenagers Following Conservative Doses of Intravenous Naloxone

Apnéia na sala de recuperação pós-anestésica: relato de caso

“…Patients should be closely observed until reaching adequate SpO 2 with no need for breathing stimulations. Since there are major differences in individual responses to opioids, the use of antagonists (naloxone) or agonist-antagonists (nalbufine) should be evaluated in a case-by-case basis [15][16][17][18][19][20][21][22][23][24][25] . When deciding for their use, the scheme of fractional naloxone or nalbufine doses proposed by Bailey 24 seems to be adequate and safe.…”

Postanaesthetic pulmonary oedema in a dog following intravenous naloxone administration after upper airway surgery

“…Others have suggested that the sympathetic response and resultant severe hypertension and tachycardia in combination with cardiac arrhythmias may lead to left-sided congestive heart failure with subsequent pulmonary oedema (Flacke and others 1977, Tanaka 1974). Alternative proposed pathophysiological mechanisms include the development of non-cardiogenic pulmonary oedema similar to neurogenic pulmonary oedema (Prough and others 1984) and the possibility of unknown effects of naloxone on peripheral opioid receptors or its interaction with other drugs have been conjectured (Pallasch and Gill 1981). …”

“…There have been several case reports of naloxone-induced pulmonary oedema in human beings (Flacke and others 1977, Taff 1983, Prough and others 1984, Partridge and Ward 1986, Schwartz and Koenigsberg 1987, Johnson and others 1995). However, to the authors' knowledge, this is the first report of pulmonary oedema following intravenous naloxone administration in a dog.…”

Butyrfentanyl Overdose Resulting in Diffuse Alveolar Hemorrhage

“…7,8 This theory is also supported by a series of opioid-naïve patients given opioids while undergoing surgery who developed opioid-related ALI after the administration of naloxone. 9 …”