Acute pulmonary edema associated with molar pregnancies: A high-risk factor for development of persistent trophoblastic disease

Orr, James W.; Austin, J. Max; Hatch, Kenneth D.; Shingleton, Hugh M.; Younger, J. Benjamin; Boots, Larry R.

doi:10.1016/0002-9378(80)90875-3

Cited by 21 publications

(3 citation statements)

References 8 publications

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“…10 In one study, the highest cases of GTN patients were from the primigravida or nullipara group, comprising 115 (37.7%) patients out of 235 patients. 11 Meanwhile, Orr et al 12 considered that parity was not significantly related to GTN risk. Although in this study the parity status of GTN patients did not have enough data, 42% did not have data, other results showed that multiparous women were the dominant group, consisting of 14 (34%) patients compared to 24% nulliparous women.…”

Section: Resultsmentioning

confidence: 99%

A profile of Gestational Trophoblastic Neoplasia in a tertiary hospital in Surabaya, Indonesia

Shabrina

Tjokroprawiro

Kurniasari

et al. 2023

MOG

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HIGHLIGHTS This study aimed to identify the characteristics of Gestational Trophoblastic Neoplasia (GTN). GTN is chemosensitive, but without appropriate therapy and follow-up, GTN will develop into complications and fatalities. ABSTRACT Objective: Gestational Trophoblastic Neoplasia (GTN) is a pregnancy-related malignancy due to abnormal proliferation of trophoblastic tissue. This study aimed to identify the characteristics of patients with GTN to help diagnose cases of GTN earlier and provide better treatment. Materials and Methods: This was a descriptive retrospective study on medical records of patients with GTN in Dr. Soetomo General Academic Hospital Surabaya, Indonesia, during the period of January 2018 to December 2020 with a total sampling technique. There were 41 patients with GTN included as study subjects. Results: Forty-one cases of GTN met the inclusion criteria out of the fifty medical records collected. The majority of patients aged 21 – 30 years old (34%) and had parity status without data (42%). Regarding the clinical profile based on prognostic factors, the predominant patients (71%) also had no data about the time interval between the end of the last pregnancy and the first time diagnosed by GTN, Those with more than 100,000 mIU/ml of beta-hCG levels were 32%, and those without metastases were 41.5%. Most patients belonged to the low-risk group (49%) and received chemotherapy (71%) with the MTX LD regimen (69%). Conclusion: GTN occurred predominantly in reproductive women that belonged to the low-risk group. Furthermore, chemotherapy is one of the chosen therapy for those patients.

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Section: Resultsmentioning

confidence: 99%

A profile of Gestational Trophoblastic Neoplasia in a tertiary hospital in Surabaya, Indonesia

Shabrina

Tjokroprawiro

Kurniasari

et al. 2023

MOG

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“…Pulmonary complications, including adult respiratory distress syndrome, are often observed at the time of molar evacuation among women with marked uterine enlargement 23,24 and should be anticipated in a woman whose uterus is larger than 14 to 16 weeks. 6 In these patients, respiratory distress syndrome may be related to anemia, hyperthyroidism, preeclampsia, or iatrogenic fluid overload.…”

Section: Complications Associated With Evacuation Of Molar Pregnanciesmentioning

confidence: 98%

Management of a Partial Molar Pregnancy

Drummond

Fritz²

2009

Journal of Perinatal &Amp; Neonatal Nursing

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Partial molar pregnancy with coexisting fetus is a rare complication of pregnancy and carries significant risks to both the mother and the fetus. Maternal risks include abnormal bleeding and the development of preeclampsia. The fetus frequently develops abnormally, often due to abnormal karyotype. This case presents a woman with a partial molar pregnancy with coexisting fetus, including diagnosis, plan of care, and delivery information.

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“…Complete enumeration technique was followed and a total of 305 female patients were included in the sample (n=Z 2 pq/e 2 , where, n=sample size, Z= standard normal variate=1.96 at 95% C.I., p=prevalence of GTD= 1 per 387 live births per year in the South east Asia=0.25%, q=1-p and e=relative error=20%). 5 Calculated sample size was estimated to be 300. Ethical permission was obtained from Institutional Review Board.…”

Section: Introductionmentioning

confidence: 99%

A prospective study of gestational trophoblastic disease profile with special reference to mortality and pregnancy outcome after successful management of the same

Bhattacharya

Panja

Bhattacharya³

et al. 2019

Int J Community Med Public Health

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Background: Gestational trophoblastic disease (GTD) is a group of rare tumors that involve abnormal growth of cells inside a woman's uterus. GTD does not develop from cells of the uterus like cervical cancer or endometrial (uterine lining) cancer do. Instead, these tumors start in the cells that would normally develop into the placenta during pregnancy. GTD is unique because the maternal lesions arise from the fetal tissue as a molar pregnancy. All forms of GTD can be treated. In most cases the treatment produces a complete cure. The study was conducted to assess the various presenting features of GTD and factors associated with it.Methods: It was an observational hospital based prospective epidemiological study. Complete enumeration technique was followed and a total of 305 female patients were included in the sample. A pre-designed and pre-tested interview schedule was used to record different information and detailed history.Results: Of the 305 patients studied, 67.2% were diagnosed with H. mole, 23% patients were diagnosed with gestational trophoblastic tumor, among them 4.9% had choriocarcinoma. Majority were primigravida and of blood group O type. Pregnancy outcome after successful management of GTD were 63.3% had full term pregnancy, 20% cases had repeat molar pregnancy, 10% had spontaneous abortion while 6.7% (2/30) had pre term delivery.Conclusions: Gestational trophoblastic disease is seen most commonly in reproductive age group. If it is not diagnosed on time it can be fatal. This is a highly curable tumor even in the presence of distant metastasis.

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Acute pulmonary edema associated with molar pregnancies: A high-risk factor for development of persistent trophoblastic disease

Cited by 21 publications

References 8 publications

A profile of Gestational Trophoblastic Neoplasia in a tertiary hospital in Surabaya, Indonesia

A profile of Gestational Trophoblastic Neoplasia in a tertiary hospital in Surabaya, Indonesia

Management of a Partial Molar Pregnancy

A prospective study of gestational trophoblastic disease profile with special reference to mortality and pregnancy outcome after successful management of the same

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