Acute psychosocial stress alters thalamic network centrality

Reinelt, Janis; Uhlig, Marie; Müller, Karsten; Lauckner, Mark E.; Kumral, Deniz; Schaare, H. Lina; Bączkowski, Błażej M.; Babayan, Anahit; Erbey, Miray; Roebbig, Josefin; Reiter, Andrea; Bae, Yoonju; Kratzsch, Juergen; Thiery, Joachim; Hendler, Talma; Villringer, Arno; Gaebler, Michael

doi:10.1016/j.neuroimage.2019.06.005

Cited by 24 publications

(33 citation statements)

References 91 publications

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“…We found no significant differences between RS 2 and RS 3 : TRS remained significantly lower in RS 3 , and LAS continued its upward trajectory, with significantly greater levels than in RS 1 . These data are in line with studies and showing a relatively slow return of connectivity to baseline levels following acute stress (Reinelt et al, 2019). In agreement with a model proposed by Hermans et al (2014), this time course of change is more similar to the trajectory of cortisol release, which only recovered to baseline at the conclusion of the experiment (T6), than selfreported stress, which was already significantly lower before RS 3 (and comparable to baseline levels) than before RS 2 .…”

Section: Functional Connectivity Does Not Return To Baseline Within 3supporting

confidence: 91%

“…Interestingly, changes in TRS correlated with an objective marker of stress (cortisol AUCg) but not with self-report, even though changes in self-reported stress and cortisol output themselves were correlated. Using the TSST, Reinelt et al (2019) reported correlations between change in eigenvector centrality in the thalamus and self-reported stress (and non-significant associations of thalamic centrality with cortisol), suggesting that information about subjective state may be carried in the ascending relay of sensory signals rather than at the cortical level. Further, our data suggest that dynamic functional connectivity in the cortex may contain information about the objective effects of stress that is not consciously accessible to individuals.…”

Section: The Role Of Trait Mindfulnessmentioning

confidence: 99%

“…Recent work has revealed that undergoing the TSST increases activity in hippocampal subregions, which predicts subsequent increases in brain areas related to emotion processing such as the insula (Chang and Yu, 2019). Finally, using graph analysis, Reinelt et al (2019) showed that stress increases the centrality of the thalamus, and that this increase persists for upwards of 105 minutes after the stressful event Thus far, little attention has been given to studying the effects of stress on time-varying or dynamic functional connectivity. While traditional static functional connectivity measures provide an estimate of network configuration averaged over a full duration of a scan run, dynamic functional connectivity can identify moment-tomoment changes in network configuration in the order of several seconds (Allen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Inter-relationships between changes in stress, mindfulness, and dynamic functional connectivity in response to a social stressor

Teng

2020

Preprint

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We conducted a study to understand how dynamic functional brain connectivity contributes to the moderating effect of trait mindfulness on the stress response. 40 participants provided subjective reports of stress, cortisol assays, and functional MRI before and after undergoing a social stressor. Self-reported trait mindfulness was also collected. Experiencing stress led to significant decreases in the prevalence of a connectivity state previously associated with mindfulness, but no changes in two connectivity states with prior links to arousal. Connectivity did not return to baseline 30 minutes after stress. Higher trait mindfulness was associated with attenuated affective and neuroendocrine stress response, and smaller decreases in the mindfulness-related connectivity state. In contrast, we found no association between affective response and functional connectivity. Taken together, these data allow us to construct a preliminary brain-behaviour model of how mindfulness dampens stress reactivity.

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Section: Functional Connectivity Does Not Return To Baseline Within 3supporting

confidence: 91%

Section: The Role Of Trait Mindfulnessmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inter-relationships between changes in stress, mindfulness, and dynamic functional connectivity in response to a social stressor

Teng

2020

Preprint

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“…Psychological relaxation was measured using the Affect Grid 40 , which assesses affective state along the two dimensions displeasure/pleasure, and arousal/sleepiness. The instrument has adequate reliability and validity 40 , 41 , and has been used in in different experimental settings, such as longitudinal ecological momentary assessment 42 , or experimental designs 43 – 45 . The score for each dimension ranges from 1 to 9.…”

Section: Methodsmentioning

confidence: 99%

Standardized massage interventions as protocols for the induction of psychophysiological relaxation in the laboratory: a block randomized, controlled trial

Meier¹,

Unternäehrer

Dimitroff³

et al. 2020

Sci Rep

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Health and disease are strongly linked to psychophysiological states. While stress research strongly benefits from standardized stressors, no established protocol focuses on the induction of psychophysiological relaxation. To maintain health, functioning regenerative systems are however likely as important as functioning stress systems. Thus, the identification of validated relaxation paradigms is needed. Here, we investigated whether standardized massages are capable of reliably inducing physiological and psychological states of relaxation. Relaxation was indicated by changes in high frequency heart rate variability (HF-HRV), a vagally-mediated heart rate variability component, and repeated ratings of subjective relaxation, and stress levels. Sixty healthy women were randomly assigned to a vagus nerve massage (n = 19), a soft shoulder massage (n = 22), or a resting control group (n = 19). During the intervention, HF-HRV and subjective relaxation increased, while subjective stress decreased significantly in all groups. Both massage interventions elicited significantly higher HF-HRV compared to the control group. Accordingly, both massage protocols increased psychophysiological relaxation, and may serve as useful tools in future research. However, future work will have to determine which of several protocols might be used as a gold standard to induce a psychophysiological state of relaxation in the laboratory.

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“…For this reason, we believe that the reason why the study outcomes regarding the correlation between subjective and objective reactivity to stress were inconsistent may be because of the imperfect coupling of different stress reactivity systems (physiology and psychology). For example, when exposed to stressors, the subjective psychological reactivity immediately occurred whereas the stable physiological reactivity occurred far more slowly (Reinelt et al, 2019). Considering the biological stress principle, in stress situations, the glucocorticoids rst in uence the participants' SNS and then the HPA system (Schoofs and Wolf, 2011).…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Stress Reactivity to the Trier Social Stress Test in Virtual Reality

Liu

Zhang

2020

Preprint

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Background: The aim of the present study is to investigate the sex differences in stress reactivity to the Trier Social Stress Test (TSST) in a virtual reality(TSST-VR). Methods: Healthy young male (n = 30) and female (n = 30) undergraduates were randomly assigned to a psychosocial stress protocol (TSST) condition or to a non-stressful control condition (Placebo-TSST) under VR. Electrodermal activity (EDA), heart rate (HR) and heart rate variability (HRV) were measured throughout the study. The subjective scales of stress and emotion were also conducted. Results: The results showed that after VR, the stress group reported higher stress perceptions than the non-stress group. Compared with females, the males stronger EDA and higher HRV before the VR, and lower HR during VR as well as higher HRV after VR. The correlation between subjective and objective reactivity demonstrated that HRV during VR was negatively correlated to depression and negative affect. The HRV after VR was negatively correlated to the positive coping but was positively correlated to the depression. Conclusions: These findings suggest that the TSST-VR could be used as an available tool for testing gender differences to social stress induction in experimental settings. Compared with females, males were more sensitive to stress.

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Acute psychosocial stress alters thalamic network centrality

Cited by 24 publications

References 91 publications

Inter-relationships between changes in stress, mindfulness, and dynamic functional connectivity in response to a social stressor

Inter-relationships between changes in stress, mindfulness, and dynamic functional connectivity in response to a social stressor

Standardized massage interventions as protocols for the induction of psychophysiological relaxation in the laboratory: a block randomized, controlled trial

Sex Differences in Stress Reactivity to the Trier Social Stress Test in Virtual Reality

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