Acute promyelocytic leukemia and pregnancy. A case report

Hoffman, Mark A.; Wiernik, Peter H.; Kleiner, George J.

doi:10.1002/1097-0142(19951201)76:11<2237::aid-cncr2820761109>3.0.co;2-f

Cited by 26 publications

(12 citation statements)

References 22 publications

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“…Patients should be closely monitored for clinical and laboratory manifestations of this coagulopathy. Prior to the ATRA era, APL treated with standard chemotherapy did not always result in live birth . However, the current management of APL during pregnancy remains potentially complicated by the potential teratogenic effect of chemotherapy, ATRA, and arsenic trioxide (ATO).…”

Section: Treatment Of Aml During Pregnancymentioning

confidence: 99%

Acute myeloid leukemia in the pregnant patient

Thomas

2015

European J of Haematology

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Although acute myeloid leukemia (AML) mostly occurs in older patients, it could be seen in women of childbearing age. It is therefore not surprising that in some patients, the management of AML will be complicated by a coexistent pregnancy. However, the association of leukemia and pregnancy is uncommon. Its incidence is estimated to be 1 in 75 000-100 000 pregnancies. During pregnancy, most leukemias are acute: two-thirds are myeloid and one-third are lymphoblastic. There is no standard approach for this clinical dilemma, in part because of variables such as the type of AML, the seriousness of the symptoms, and the patient's personal beliefs. In many cases, the diagnostic workup has to be altered because of the pregnancy, and often available treatments have varying risks to the fetus. While chemotherapy is reported to have some risks during the first trimester, it is admitted that it can be administered safely during the second and the third trimesters.

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Section: Treatment Of Aml During Pregnancymentioning

confidence: 99%

Acute myeloid leukemia in the pregnant patient

Thomas

2015

European J of Haematology

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“…APL is recognized to occur infrequently during pregnancy. APL is characterized by an onset at young age and life-threatening bleeding diathesis attributed to disseminated intravascular coagulation (DIC)-like coagulopathy [61,62]. The discovery of all trans-retinoic acid (ATRA) has changed the course of APL treatment by reducing the onset of DIC and inducing complete and durable remissions in more than 90% of patients [61].…”

Section: Apl In Pregnancymentioning

confidence: 99%

Update on Leukemia in Pregnancy

Al-Anazi¹

2015

Leukemias - Updates and New Insights

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Leukemia is a rare event in pregnancy. Acute leukemia represents % of leukemias occurring during pregnancy with AML accounting for two thirds of these cases.During the first trimester of pregnancy, standard chemotherapy has a teratogenicity rate of up to % depending on the specific agent employed. Exposure to cytotoxic agents during the second and third trimesters is not teratogenic but may predispose the fetus to growth retardation, premature delivery and bone marrow suppression.Additionally, the mother and the fetus are at risk of thromboembolism and sepsis.

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“…Acute leukemia during pregnancy is very rare with an estimated frequency of 1 in 75,000-100,000 [3, 6, 7]. AML accounts for approximately two-thirds of leukemia cases seen during pregnancy and the diagnosis is generally made during the second and third trimesters [3, 5].…”

Section: Casementioning

confidence: 99%

“…The exact incidence of acute promyelocytic leukemia (APL) in pregnant women is unknown; however, approximately 50 such cases have been reported in the literature [1-4, 7, 8]. APL is a unique type of acute myeloid leukemia (AML) characterized by proliferation of neoplastic promyelocytes bearing a specific chromosomal translocation t(15;17).…”

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confidence: 99%