Acute presentation of giant parathyroid adenoma extending to the mediastinum: A case report

Houas, Jihène; Monia, Ghammam; Chouchane, Lobna; Bellakhdher, Mouna; Dardouri, Taheni; Abdelkefi, Mohamed

doi:10.1016/j.ijscr.2023.108282

Cited by 1 publication

(2 citation statements)

References 13 publications

(21 reference statements)

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“…[ 1 ] This technique is crucial for the precise localization of suspicious parathyroid lesions in the preoperative phase, influencing surgical outcomes, and enhancing success rates in primary hyperparathyroidism (PHPT). [ 2 , 3 ] P-FNA with PTH washout offers a minimally invasive approach, potentially shortening recovery time and reducing surgical complications. It is particularly beneficial in ambiguous cases, aiding accurate preoperative planning.…”

Section: Introductionmentioning

confidence: 99%

“…It is particularly beneficial in ambiguous cases, aiding accurate preoperative planning. [ 3 ] Recent studies, such as those by Canpolat et al [ 4 ] and Triggiani et al, [ 5 ] have focused on the diagnostic value of PTH washout in patients with negative or inconclusive scintigraphy results, highlighting its importance in differentiating parathyroid from thyroid lesions and improving surgical outcomes. Various complications associated with P-FNA combined with PTH washout have been identified, including fibrosis, abscess formation, hematoma, and cutaneous spread of parathyroid carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Parathyroid fine needle aspiration with PTH washout: Can it lead to parathyroid cell seeding in primary hyperparathyroidism?

Balbaloglu,

Deniz,

Ozaydin

et al. 2024

Medicine

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Although parathyroid fine-needle aspiration (P-FNA) with parathyroid hormone (PTH) washout is effective in detecting preoperative parathyroid lesions, it also presents risks such as fibrosis, hematoma, and, in rare cases, tumor seeding. This study aimed to investigate whether P-FNA with PTH washout leads to the seeding of parathyroid cells along the path of the needle. A retrospective analysis was conducted on patients undergoing minimally invasive parathyroidectomy guided by preoperative PTH washout. Permanent pathology reports, imaging data, and postoperative serum parathyroid hormone and calcium levels were assessed to determine the effectiveness and safety of the procedure. Complications following P-FNA with PTH washout were also reviewed using data from the patient registration system of Bulent Ecevit University. The procedure accurately localized parathyroid adenomas in 87 patients who underwent ultrasound-guided parathyroidectomy following preoperative P-FNA and PTH washout. Postoperatively, 75 patients showed normal parathyroid hormone and calcium levels. Two patients required secondary surgery for contralateral adenomas. Critically, there was no evidence of P-FNA with PTH washout-induced parathyromatosis or seeding during the follow-up. Effective adenoma localization is crucial for successful minimally invasive surgery of hyperparathyroidism. Our study indicates that combining preoperative P-FNAB with PTH washout and imaging enhances adenoma detection, especially when intraoperative PTH measurements are not available, thus improving surgical outcomes. Notably, we found no evidence of cell implantation after P-FNA, suggesting the safety and efficacy of this method for preventing parathyroid cell seeding.

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Section: Introductionmentioning

confidence: 99%