Acute presentation of autoimmune hepatitis in a patient with myasthenia gravis, thymoma, Hashimoto thyroiditis and connective tissue disorder

Yapalı, Suna; Oruç, Nevin; Ilgun, Sibel; Yılmaz, Funda; Aksu, Kenan; Yılmaz, Mustafa; Günşar, Fulya

doi:10.1111/j.1872-034x.2012.00985.x

Cited by 11 publications

(8 citation statements)

References 22 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thymomas produce autoantigen specific T cells by abnormal positive or negative T cell selection, leading to MG, as well as some other autoimmune disorders. These T cells then leave the thymoma to induce autoimmune disease [ 56 ]. Risk of thymoma in MG is associated with the TT homozygous genotype and the DNMT3B-579T allele [ 56 ].…”

Section: Associated Autoimmune Disorders In Thymoma-mgmentioning

confidence: 99%

“…These T cells then leave the thymoma to induce autoimmune disease [ 56 ]. Risk of thymoma in MG is associated with the TT homozygous genotype and the DNMT3B-579T allele [ 56 ]. This genotype does not occur with increased frequency in MG patients without thymoma, even after stratification into MG subgroups [ 57 ].…”

Section: Associated Autoimmune Disorders In Thymoma-mgmentioning

confidence: 99%

See 1 more Smart Citation

Complicating autoimmune diseases in myasthenia gravis: a review

et al. 2015

View full text Add to dashboard Cite

Myasthenia gravis (MG) is a rare autoimmune disease of skeletal muscle endplates. MG subgroup is relevant for comorbidity, but usually not accounted for. MG patients have an increased risk for complicating autoimmune diseases, most commonly autoimmune thyroid disease, systemic lupus erythematosus and rheumatoid arthritis. In this review, we present concomitant autoimmune disorders associated with the different MG subgroups, and show how this influences treatment and prognosis. Concomitant MG should always be considered in patients with an autoimmune disorder and developing new neuromuscular weakness, fatigue or respiratory failure. When a second autoimmune disorder is suspected, MG should be included as a differential diagnosis.

show abstract

Section: Associated Autoimmune Disorders In Thymoma-mgmentioning

confidence: 99%

Section: Associated Autoimmune Disorders In Thymoma-mgmentioning

confidence: 99%

Complicating autoimmune diseases in myasthenia gravis: a review

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Other organ systems may be affected by PNDs in patients with thymic tumors, including skin manifestations such as pemphigus, vitiligo or alopecia, 40, 41 immunodeficiency such as Good's syndrome, 42 autoimmune hepatitis, 43 autoimmune thyroiditis, 44 hematological disorders such as aplastic anemia, 45 and retinopathy. 46 …”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic Disorders in Thymoma Patients

Evoli

Lancaster

2014

Journal of Thoracic Oncology

113

View full text Add to dashboard Cite

Thymic malignancy is often associated with paraneoplastic neurological diseases (PNDs) and recognition of these disorders is important for physicians who treat these patients. The most common thymoma-associated PNDs are myasthenia gravis, acquired neuromyotonia (Isaacs' syndrome), encephalitis, Morvan's syndrome, and myositis. Diagnosis of these disorders is complex but often aided by testing for specific autoantibodies, including those to the acetylcholine receptor (AChR) for myasthenia gravis and to Caspr2, protein of the voltage-gated potassium channel (VGKC) complex, in patients with acquired neuromyotonia, Morvan's syndrome, or encephalitis. Patients who manifest these disorders should be screened for thymoma at diagnosis, and worsening of these PNDs may be associated with recurrent thymoma. These disorders can cause profound disability but usually respond to immunotherapy, and often improve with thymoma treatment. Close cooperation among a team of specialists is required to properly care for these patients.

show abstract

“…1 Autoimmune disorders occur with thymoma, the most common of which is MG. 2 AIH has also been reported. 3 Upto 7% of patients with thymoma and MG have other paraneoplastic conditions. 4 Although thymectomy is the preferred treatment modality, not all patients are surgical candidates.…”

mentioning

confidence: 99%