Acute poststreptococcal glomerulonephritis: an update

Abstract

Severe group A streptococcal disease including acute poststreptococcal glomerulonephritis remains a cause of morbidity and mortality in developing countries and among impoverished populations. Various reports on the diverse clinical manifestations that can be associated with the condition will aid physicians in prompt diagnosis and intervention, while studies focusing on better understanding of immunopathogenesis may facilitate vaccine development and prevention.

Prognostic Factor of Ureum and Creatinine Serum of Acute Post Streptococcal Glomerulonephritis in Children

“…Bingler et al reported APSGN generally in children above 6 years whereas Ahn et al obtanined lower in children under 2 years because of the immune complex system is still immature and pharyngitis incidence. 5,7 Statistical analyses did not show a significant difference between age and APSGN patient outcomes (p= 0.108) and same as the report by Mossie and Shimels. 3 However, Ahn and Suarta IK et al concluded that older children as poor prognostic factor.…”

“…3 However, Ahn and Suarta IK et al concluded that older children as poor prognostic factor. 6,7 Our study did not show a significant difference between nutritional status and outcomes (p= 1.000). Same result was reported by Mossie and Shimels in Ethiopia.…”

“…11 The reason may be due to male often being outside home and exposed to streptococcus beta hemoliticus group A infection. 7 The mean age of patient is 9.56 years with range of 3.4 -14.67 years but other showed the mean age of 6-8 years. Bingler et al reported APSGN generally in children above 6 years whereas Ahn et al obtanined lower in children under 2 years because of the immune complex system is still immature and pharyngitis incidence.…”

“…Therefore, it is important and necessary to carry out a study concerning the relationship between serum ureum and creatinine level and the course of illness and outcome of children with APSGN. 7 Etuk et al found the mean of serum creatinine levels of patients with APSGN was 1.5 mg/dl but the serum creatinine level is not a prognostic factor of APSGN. 8 Other study in Iran by Sepahi et al, and Kumar concluded that decreased renal function influences the quality of life associated with morbidity and mortality of patients.…”

Prognostic factors for mortality in pediatric acute poststreptococcal glomerulonephritis

“…2 Also, Etuk et al 7 reported 56% males and 44% females; 7 Albar et al 8 reported APSGN in 58.3% males and 41.7% females; 8 and Sepahi et al reported a male: female ratio of 1.23: 1. 9 According to Ahn et al 10 ,this discrepancy could be due to males more often engaging in activities outside the house, making them more likely to be exposed to BHAS. 10 The mean age of our subjects was 9.36 years, with a range of 3.42 to 14.67 years.…”