Acute postoperative pain is correlated with the early onset of postpartum depression after cesarean section: a retrospective cohort study

Dandan, Shen; Hasegawa-Moriyama, Maiko; Ishida, Kumiko; Fuseya, Satoshi; Tanaka, Satoshi; Kawamata, Mikito

doi:10.1007/s00540-020-02789-5

Cited by 22 publications

(27 citation statements)

References 11 publications

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“…More seriously, long-term chronic pain may lead to postpartum depression (PPD). A previous study indicated that postoperative pain was correlated with the early onset of PPD after CS (8). PPD is present in 10-20% of pregnant women, mostly within 1 year after delivery (9)(10)(11).…”

Section: Introductionmentioning

confidence: 96%

Effect of low-dose esketamine on pain control and postpartum depression after cesarean section: a retrospective cohort study

Wang¹,

Zhang²,

Xu³

et al. 2022

Ann Palliat Med

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Background: Esketamine is used to control postoperative pain and reduce postoperative depression in surgical patients. This study was performed to determine the effects of esketamine on pain control as well as postpartum depression (PPD) in pregnant women who underwent cesarean section (CS).Methods: Pregnant women who underwent CS between March 2018 and February 2020 at our hospital were retrospectively reviewed. Parturients in the control group received 50 µg sufentanil citrate and 0.25 mg palonosetron hydrochloride, while those in the experimental group received additional 0.2-0.5 mg/kg esketamine. The primary outcomes included postoperative pain control according to the numeric rating scale (NRS) and the incidence of PPD according to the Edinburgh postnatal depression scale (EPDS).Multivariable linear regression analysis was performed to determine the relationship between the use of esketamine, pain control, and the incidence of PPD after CS.Results: There were 132 parturients in the control group and 108 parturients in the esketamine group in this study. All NRS scores at rest at any time point were much lower in the esketamine group than those in the control group. Besides, NRS scores when coughing were also lower in the esketamine group within 24 hours. EPDS scores were lower in the esketamine group than those in the control group within 3 months postpartum. Esketamine acted as a protector of pain control and was confirmed to improve the incidence of PPD using multivariable linear regression. Parturients had dramatically better sleep quality within 1 week postpartum (P=0.044), and morphine consumption within 24 hours postpartum was lower in the esketamine group than in the control group (P<0.001). The quality of recovery within 3 months postpartum was also better in the esketamine group (P=0.001). A subgroup analysis of 2 subgroups divided according to the dose of esketamine was then performed, indicating no significant difference between the low-dose group and high-dose group in most included outcomes.Conclusions: This study confirmed the effects of esketamine on pain control and the incidence of PPD in pregnant women who underwent CS. Considering the potential adverse events, low-dose esketamine may be more suitable for pregnant women who have undergone CS.

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Section: Introductionmentioning

confidence: 96%

Effect of low-dose esketamine on pain control and postpartum depression after cesarean section: a retrospective cohort study

Wang¹,

Zhang²,

Xu³

et al. 2022

Ann Palliat Med

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“…The returned incomplete questionnaire forms were timely supplemented on site. One day after the operation, the pain was assessed with the NRS (Suffeda et al, 2016;Gravani et al, 2020;Shen et al, 2020) when the patient was awake.…”

Section: General Informationmentioning

confidence: 99%

“…A report points out that postoperative pain is not adequately managed in greater than 80% of patients in the United States (Gan, 2017). If pain cannot be fully controlled, acute postoperative pain is harmful and may cause great distress to patients (Schug, 2011;Gravani et al, 2020;Shen et al, 2020).…”

Section: Postoperative Painmentioning

confidence: 99%

Preoperative Anxiety and Postoperative Pain in Patients With Laparoscopic Hysterectomy

et al. 2021

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Objective: This study was designed to investigate preoperative anxiety situations and postoperative pain degree in Chinese patients undergoing laparoscopic hysterectomy and to analyze the related factors of preoperative anxiety and the correlation between preoperative anxiety and postoperative pain to provide a reference for effective postoperative analgesia management.Methods: A total of 100 female patients undergoing laparoscopic hysterectomy were enrolled in this study and randomly divided into two groups (n = 50, each). In group A, the patients were treated with dexmedetomidine and sufentanil for postoperative analgesia. In group B, the patients were treated with sufentanil alone for postoperative analgesia. All patients were evaluated with a self-rating anxiety scale (SAS) 1 day before the operation. The patients’ pain was evaluated using the numerical rating scale (NRS) 1 day after the operation, and data were recorded.Results: In these 100 patients, the highest preoperative SAS score was 48, and the average score was 40.99 ± 4.55 points, which is higher than the norm in China. There were significant differences in preoperative SAS scores among patients with different occupations and previous surgical experience (P < 0.05). There was no significant difference in SAS scores among patients with different education levels (P > 0.05). The postoperative NRS score of group A was significantly higher than that of group B, and the difference was statistically significant (P < 0.05). The correlation coefficients between SAS scores and NRS scores in groups A and B were 0.836 and 0.870, respectively, presenting with a significantly positive correlation.Conclusion: Preoperative anxiety is an important predictor of postoperative pain. Patients undergoing laparoscopic hysterectomy have preoperative anxiety. The degree of anxiety is influenced by the occupation and previous operation experience of the patients, and patients with higher preoperative anxiety have greater postoperative pain. In addition, we should not neglect the management of postoperative pain because of the small trauma of laparoscopic surgery, and dexmedetomidine combined with sufentanil can improve the postoperative analgesic effect.

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“…Herein, we aimed to compare the incidence rate of PPD in PE and normal women by employing the EPDS and to comprehensively evaluate the association between PPD and PE, especially its severity and complications. In addition, it has been previously reported that pelvic floor symptoms, urinary incontinence, and pain would affect postpartum moods [16,17], so we also employed the Leakage Index Questionnaire and the pain scale.…”

Section: Introductionmentioning

confidence: 99%

Preeclampsia and Its Complications Exacerbate Development of Postpartum Depression: A Retrospective Cohort Study

shan¹,

ye³

et al. 2020

Preprint

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Background. Hypertensive disorders were proved to be associated with the development of depression. But it is unclear if pregnancy-induced hypertensive diseases, especially preeclampsia (PE), will affect postpartum moods. We aimed to determine the incidence rate of postpartum depression (PPD) in PE patients and comprehensively evaluate the association between PPD and PE, including its severity and complications. Methods. 425 participants including 130 PE mothers were enrolled in this retrospective cohort study. Each woman was asked to complete a questionnaire integrating the Edinburgh Postnatal Depression Scale (EPDS), the Leakage Index Questionnaire, and a pain scale questionnaire within 6 weeks after delivery. The EPDS cut-off score above 13 was recognized as screening positive for PPD. Data between groups were compared by bivariate analysis. Results. PE mothers showed a direct tendency to PPD development. The positive screening for PPD in the PE group was significantly higher than that of the control group (30.77% vs. 14.58%). Based on the results of the regression model, women diagnosed with severe PE and fetal growth restriction were more inclined to develop PPD than normal ones (AOR: 2.759, 95% CI: 1.206-6.315 and AOR: 3.450, 95% CI: 1.596-7.458). It is also indicated that postpartum pain exacerbated the odds of PPD in PE patients (AOR: 1.509, 95% CI: 1.078-2.114). Conclusions. PE was an independent risk factor for PPD. Its severity and complications exacerbate the development of PPD. Doctors and society should pay more attention to PE patients after delivery against the development of PPD.

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Acute postoperative pain is correlated with the early onset of postpartum depression after cesarean section: a retrospective cohort study

Cited by 22 publications

References 11 publications

Effect of low-dose esketamine on pain control and postpartum depression after cesarean section: a retrospective cohort study

Effect of low-dose esketamine on pain control and postpartum depression after cesarean section: a retrospective cohort study

Preoperative Anxiety and Postoperative Pain in Patients With Laparoscopic Hysterectomy

Preeclampsia and Its Complications Exacerbate Development of Postpartum Depression: A Retrospective Cohort Study

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