Acute postoperative pain exacerbates neuroinflammation and related delirium-like cognitive dysfunction in rats

Koyama, Tsuyoshi; Kawano, Takashi; Iwata, Hisato; Aoyama, Bun; Eguchi, Satoru; Nishigaki, Atsushi; Yamanaka, Daiki; Tateiwa, Hiroki; Shigematsu-Locatelli, Marie; Locatelli, Fabricio M.; Yokoyama, Masataka

doi:10.1007/s00540-019-02635-3

Cited by 20 publications

(22 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…POD-like behavior changes have been confirmed to be correlated with increased inflammatory response and neuro-dysfunction in pre-frontal cortex in animal studies. 19 , 20 Results from Western blot showed that MANF reduced with aging in adult normal mice. MANF level in cortex of six-month, nine-month- and eighteen-month-old mice were significantly lower than that in three-month mice ( Figure 2B ).…”

Section: Resultsmentioning

confidence: 99%

The Potential Protective Effect of Mesencephalic Astrocyte-Derived Neurotrophic Factor on Post-Operative Delirium via Inhibiting Inflammation and Microglia Activation

Liu¹,

Shen²,

Zhang³

et al. 2021

JIR

View full text Add to dashboard Cite

Background The increased inflammation is closely correlated with post-operative delirium (POD). Mesencephalic astrocyte-derived neurotrophic factor (MANF) shows protective effect on inflammatory diseases. However, the relationship between MANF and POD is still undefined. This study aimed to explore the potential effect of MANF on POD. Methods Pre- and post-operative levels of MANF and inflammatory cytokines were measured in serum from POD and non-POD patients by ELISA, as well as endogenous MANF in serum from healthy individuals with different ages. Endogenous MANF in mice brain from different ages was also measured. Abdominal surgery was performed for POD mice model. POD-like behavior changes in mice were evaluated using buried food test, open field test and Y maze test. Results Endogenous MANF was decreased in age-dependent manner in both humans and mice. The pre-operative level of MANF in serum from POD patients was lower compared with that in non-POD patients (p=0.016). MANF increase in serum after surgery was less in POD patients than that in non-POD patients (p<0.001). In mice, recombinant human MANF reversed the surgery-induced elongation of latency to eat food, increase in latency to center and increase in time in center in open field test, and also increase in duration in novel arm in Y maze test. In addition, MANF inhibited surgery-induced inflammation, microglial activation and M1 polarization in mice. Conclusion The relative low MANF level may contribute to POD in the elderly. MANF has a protective role against POD-like behavior changes in mice.

show abstract

Section: Resultsmentioning

confidence: 99%

The Potential Protective Effect of Mesencephalic Astrocyte-Derived Neurotrophic Factor on Post-Operative Delirium via Inhibiting Inflammation and Microglia Activation

Liu¹,

Shen²,

Zhang³

et al. 2021

JIR

View full text Add to dashboard Cite

show abstract

“…[ 19 ] In addition, pain is closely related to neuroinflammation. [ 20 ] A recent study by Koyama et al [ 21 ] described that acute postoperative pain exacerbates neuroinflammation and related delirium-like cognitive dysfunction in rats. Effective analgesia can lower stress levels and consequently reduce the systemic inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy

Jin

Yao²,

Heng

et al. 2020

Medicine

View full text Add to dashboard Cite

show abstract

“…[140][141][142] Pain assessments A limited number of studies suggest an association between acute postoperative pain and delirium. [143][144][145] Therefore, serial pain evaluations will be completed using the Behavioral Pain Scale (BPS)/BPS Non-Intubated and the Visual Analog Scale. 146 Evaluations will be performed after each CAM assessment.…”

Section: Confusion Assessment Methodsmentioning

confidence: 99%

Protocol for the Prognosticating Delirium Recovery Outcomes Using Wakefulness and Sleep Electroencephalography (P-DROWS-E) study: a prospective observational study of delirium in elderly cardiac surgical patients

et al. 2020

View full text Add to dashboard Cite

IntroductionDelirium is a potentially preventable disorder characterised by acute disturbances in attention and cognition with fluctuating severity. Postoperative delirium is associated with prolonged intensive care unit and hospital stay, cognitive decline and mortality. The development of biomarkers for tracking delirium could potentially aid in the early detection, mitigation and assessment of response to interventions. Because sleep disruption has been posited as a contributor to the development of this syndrome, expression of abnormal electroencephalography (EEG) patterns during sleep and wakefulness may be informative. Here we hypothesise that abnormal EEG patterns of sleep and wakefulness may serve as predictive and diagnostic markers for postoperative delirium. Such abnormal EEG patterns would mechanistically link disrupted thalamocortical connectivity to this important clinical syndrome.Methods and analysisP-DROWS-E (Prognosticating Delirium Recovery Outcomes Using Wakefulness and Sleep Electroencephalography) is a 220-patient prospective observational study. Patient eligibility criteria include those who are English-speaking, age 60 years or older and undergoing elective cardiac surgery requiring cardiopulmonary bypass. EEG acquisition will occur 1–2 nights preoperatively, intraoperatively, and up to 7 days postoperatively. Concurrent with EEG recordings, two times per day postoperative Confusion Assessment Method (CAM) evaluations will quantify the presence and severity of delirium. EEG slow wave activity, sleep spindle density and peak frequency of the posterior dominant rhythm will be quantified. Linear mixed-effects models will be used to evaluate the relationships between delirium severity/duration and EEG measures as a function of time.Ethics and disseminationP-DROWS-E is approved by the ethics board at Washington University in St. Louis. Recruitment began in October 2018. Dissemination plans include presentations at scientific conferences, scientific publications and mass media.Trial registration numberNCT03291626.

show abstract

Acute postoperative pain exacerbates neuroinflammation and related delirium-like cognitive dysfunction in rats

Cited by 20 publications

References 12 publications

The Potential Protective Effect of Mesencephalic Astrocyte-Derived Neurotrophic Factor on Post-Operative Delirium via Inhibiting Inflammation and Microglia Activation

The Potential Protective Effect of Mesencephalic Astrocyte-Derived Neurotrophic Factor on Post-Operative Delirium via Inhibiting Inflammation and Microglia Activation

Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy

Protocol for the Prognosticating Delirium Recovery Outcomes Using Wakefulness and Sleep Electroencephalography (P-DROWS-E) study: a prospective observational study of delirium in elderly cardiac surgical patients

Contact Info

Product

Resources

About