Acute postoperative endophthalmitis: Microbiology from the laboratory to the bedside

Chiquet, C.; Bron, Alain M.; Lundström, Mats; Maurin, Max

doi:10.1016/j.survophthal.2022.07.001

Cited by 6 publications

(3 citation statements)

References 99 publications

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“…52.38% [21]and 60% ( [22]judged it to be otherwise. Both the presence of infection and assessments of the diversity, pathogenicity, and resistance patterns of these bacteria may be performed with high precision using molecular techniques suchas polymerase chain reaction [23]Although PCR has a number of benefits, including high specificity, rapid findings, and the capacity to type bacteria, its widespread use has been hampered by its expensive price tag and lack of practical application ] 24]…”

Section: Hpyloridetection By Pcr Techniquementioning

confidence: 99%

Molecular detection of Helicobacter pylori isolated from biopsies of gastritis patients based on the presence of 16srRNA and VacA S1/S2-UreA virulence genes

Alrubaye,

Awadh,

Faris

2024

Tikrit J. Pure Sci.

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Background: Although most infections with Helicobacter pylori are asymptomatic, some people with this bacterium end up with chronic gastritis, peptic ulcers, or even stomach cancer. The study's objectives wasto detectthe prevalence of Helicobacter pylori by identifying 16sRNA and to determine the virulence genes (ureA and vacAS1/S2) in biopsies of patients with gastritis. Method: The study was conducted between September 2022 and June 2023 at the public hospital and several private clinics in Balad City, Iraq. A total of 50 samples were taken, spanningfrom 15-85 years of age (50 patients). Balad General Hospital and a private upper surgical endoscopy clinic. The specialist doctor (gastroenterologist) took the gastric biopsy samples from the stomach's antrum and corpus during normal endoscopy. The gastric biopsies were used for PCR. Results: The current study includes 50 samples suffering from gastritis. Patients according to age groups 26-34 and 45-54 had the highest frequency, while, 55-64 had the lowest frequency. Helicobacter Pylori was detected by16SrRNA. According to the result 16SrRNA by, the research found that positive gastric patients was42 (84%) and 8(16%) negative. In addition, this research found that the UreA gene was39 (78%) positive and 11(22%) negative and theVacS1/S2 gene was22 (44%) positive and 28(56%) negative.

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Section: Hpyloridetection By Pcr Techniquementioning

confidence: 99%

Molecular detection of Helicobacter pylori isolated from biopsies of gastritis patients based on the presence of 16srRNA and VacA S1/S2-UreA virulence genes

Alrubaye,

Awadh,

Faris

2024

Tikrit J. Pure Sci.

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“…Yield rates of stains and cultures varied but are generally low [ 40 , 42 , 43 ]. Recently, polymerase chain reaction (PCR) came into view as a promising, rapid, and precise alternative [ 44 , 45 ]. It had been advocated for timely pathogen identification in endophthalmitis.…”

Section: Key Question 2: What Is the Optimal Clinical Approach Of Pat...mentioning

confidence: 99%

Literature- and Experience-Based Consensus for Acute Post-operative Endophthalmitis and Endogenous Endophthalmitis in Taiwan

Lee,

Sheu,

Chen

et al. 2023

Ophthalmol Ther

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Clinical practices on acute post-operative and endogenous endophthalmitis (EnE) are highly variable among clinicians due to a lack of up-to-date, high-quality evidential support. An expert consensus is thus much needed. A panel consisting of ten retinal specialists in Taiwan was organized. They evaluated relevant literature and developed key questions regarding acute post-operative and EnE that are cardinal for practice but yet to have conclusive evidence. The panel then attempted to reach consensus on all the key questions accordingly. There were eight key questions proposed and their respective consensus statements were summarized as follows: Gram staining and culture are still the standard procedures for the diagnosis of endophthalmitis. Vitrectomy is recommended to be performed earlier than the timing proposed by the Endophthalmitis Vitrectomy Study (EVS). Routine intracameral antibiotic injection for post-cataract surgery endophthalmitis prophylaxis is not recommended because of potential compounding error hazards and a lack of support from high-quality studies. Routine fundus examination is recommended for all patients with pyogenic liver abscess. In EnE, vitrectomy is recommended if diffused and dense vitritis is present, or if the disease progresses. These consensus statements may work as handy guidance or reference for clinical practices of acute post-operative and EnE.

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“…A feared complication of any intraocular procedure is acute infectious endophthalmitis (AE), commonly caused by introduction of bacteria into the eye, which can result in devastating loss of vision or loss of the eye itself. 1 This condition is an ophthalmic emergency and requires antibiotics and/or surgical intervention. As a result, landmark studies such as the Endophthalmitis Vitrectomy Study 2 and the European Society for Cataract and Refractive Surgery Study 3 have been undertaken to reduce the incidence of and develop effective treatment algorithms for AE, respectively, in commonly performed procedures such as cataract surgery.…”

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confidence: 99%

Clinical Outcomes of Acute Endophthalmitis After Intravitreal Delivery of Vascular Endothelial Growth Factor Inhibitors Versus Steroids

Adams

Sodhi

Vagaggini

et al. 2023

Retina

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Purpose: To compare patients with acute endophthalmitis after intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors vs. steroids.Methods: Retrospective single-center, nonrandomized interventional study from 2013 to 2021.Patients underwent vitreous biopsy before initiating treatment and were divided into the following cohorts: (1) anti-VEGF managed medically (T&I-anti-VEGF), (2) anti-VEGF managed by immediate pars plana vitrectomy (PPV-anti-VEGF), and (3) steroid therapy and managed medically or by pars plana vitrectomy (steroid).Results: A total of 141 patients were analyzed. The steroid cohort demonstrated significantly worse presenting (median = 2.80 logarithm of the minimum angle of resolution [logMAR]; P # 0.01) and final (median = 2.30 logMAR) best-corrected visual acuity compared with T&I-anti-VEGF (presenting: median = 2.00 logMAR; final: median = 0.40 logMAR) and pars plana vitrectomy-anti-VEGF cohorts (presenting: median = 2.30 logMAR; final: median = 0.48 logMAR). There was no significant (P = 0.33) difference in the final best-corrected visual acuity between T&I-anti-VEGF and pars plana vitrectomyanti-VEGF cohorts. There were no significant (P $ 0.63) differences among cohorts in best-corrected visual acuity before acute endophthalmitis diagnosis (T&I-anti-VEGF: median = 0.40 logMAR; pars plana vitrectomy-anti-VEGF: median = 0.40 logMAR; steroid: median = 0.44 logMAR). Microbial cultures revealed similar profiles for all cohorts.Conclusion: Acute endophthalmitis after intravitreal injection steroid therapy had worse outcomes compared with anti-VEGF therapy.

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Acute postoperative endophthalmitis: Microbiology from the laboratory to the bedside

Cited by 6 publications

References 99 publications

Molecular detection of Helicobacter pylori isolated from biopsies of gastritis patients based on the presence of 16srRNA and VacA S1/S2-UreA virulence genes

Molecular detection of Helicobacter pylori isolated from biopsies of gastritis patients based on the presence of 16srRNA and VacA S1/S2-UreA virulence genes

Literature- and Experience-Based Consensus for Acute Post-operative Endophthalmitis and Endogenous Endophthalmitis in Taiwan

Clinical Outcomes of Acute Endophthalmitis After Intravitreal Delivery of Vascular Endothelial Growth Factor Inhibitors Versus Steroids

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