Acute polyradiculoneuropathy complicating systemic lupus erythematosus

Morgan, S. H.; Kennett, R P; Dudley, Christopher; Mackworth‐Young, Charles; Hull, Richard; Hughes, G. R. V.

doi:10.1136/pgmj.62.726.291

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…Previous descriptions of Guillain -Barré-like illness in SLE have reported successful use of cyclophosphamide. 4,6,12 To our knowledge, there are no previous reports of a bene cial impact of intravenous immunoglobulin on the acute pattern of peripheral neuropathy in SLE.…”

Section: Discussionmentioning

confidence: 97%

“…Our patient exhibited these features in the context of SLE, a disorder that may be associated with miscellaneous neuropsychiatric manifestations including an acute peripheral neuropathy. [4][5][6] The recurrence of the neuropathy indicates that it was not an incidental illness. After the rst episode the patient made a dramatic and strikingly complete recovery, apparently in response to a single ve-day course of i.v.…”

Section: Discussionmentioning

confidence: 99%

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Systemic lupus erythematous with recurrent Guillain -Barré-like syndrome treated with intravenous immunoglobulins

Lewis

Gibson

2003

Lupus

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We report on an unusual case of a young African male with systemic lupus erythematosus who developed an acute, severe Guillain-Barré-like peripheral neuropathy associated with ascites. The illness appeared to respond dramatically to a short course of intravenous immunoglobulins. Eight months later he had recurrence of identical features. He required respiratory support. On this occasion there was no response to intravenous immunoglobulins or other measures and he died of sepsis after a protracted period of paralysis.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Systemic lupus erythematous with recurrent Guillain -Barré-like syndrome treated with intravenous immunoglobulins

Lewis

Gibson

2003

Lupus

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“…Several authors have reported neurological manifestations similar to GBS in patients with SLE. [8][9][10][11][12][13][14] Some claimed a possible involvement of immunological abnormalities in SLE in the pathogenesis of GBS. Robson et al 14 reviewed these cases and suggested the mechanisms of GBS onset in SLE patients.…”

Section: Discussionmentioning

confidence: 99%

Guillain-Barr� syndrome accompanied by central nervous system lupus in a patient with juvenile rheumatoid arthritis

Nakajima

Higami

Yamanaka

et al. 2001

Modern Rheumatology

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We describe a 17-year-old female with juvenile rheumatoid arthritis accompanied by Guillain-Barré syndrome (GBS) during the course of central nervous system (CNS) lupus. She initially developed CNS lupus, including headache and convulsion. A high-signal area in a magnetic resonance scan of her brain with T2-weighted images was noted, and her cerebrospinal fluid exhibited increased levels of IgG and interleukin-6. Eighteen days after the onset of CNS lupus, polyneuropathy in the lower extremities developed, and a diagnosis of GBS was made. No obvious preceding infections in the upper respiratory or gastrointestinal systems were noted before the onset of GBS, indicating that GBS might be part of the symptoms of CNS lupus.

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The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes

Liang

Corzillius

Bae

et al. 1999

Arthritis & Rheumatism

1,787

193

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Objective. To develop a standardized nomenclature system for the neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE).Methods. An international, multidisciplinary committee representing rheumatology, neurology, psychiatry, neuropsychology, and hematology developed case definitions, reporting standards, and diagnostic testing recommendations. Before and after the meeting, clinician committee members assigned diagnoses to sets of vignettes randomly generated from a pool of 108 NPSLE patients. To assess whether the nomenclature system improved diagnostic agreement, a consensus index was developed and pre-and postmeeting scores were compared by t-tests.Results. Case definitions including diagnostic criteria, important exclusions, and methods of ascertainment were developed for 19 NPSLE syndromes. Recommendations for standard reporting requirements, minimum laboratory evaluation, and imaging techniques were formulated. A short neuropsychological test battery for the diagnosis of cognitive deficits was proposed. In the postmeeting exercise, a statistically significant improvement in diagnostic agreement was observed.Conclusion. The American College of Rheumatology (ACR) Nomenclature for NPSLE provides case definitions for 19 neuropsychiatric syndromes seen in SLE, with reporting standards and recommendations for laboratory and imaging tests. It is intended to facilitate and enhance clinical research, particularly multicenter studies, and reporting. In clinical settings, consultation with other specialists may be required. It should be useful for didactic purposes but should not be used uncritically or as a substitute for a clinical diagnosis. The complete case definitions are available on the ACR World Wide Web site: http://www.rheumatology .org/ar/ar.html.

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Acute polyradiculoneuropathy complicating systemic lupus erythematosus

Abstract: Summary Two elderly patients with systemic lupus erythematosus (SLE) are presented. Both developed an acute polyradiculoneuropathy which is an unusual complication of this disease. Features of their presentation are discussed.

Cited by 9 publications

References 24 publications

Systemic lupus erythematous with recurrent Guillain -Barré-like syndrome treated with intravenous immunoglobulins

Systemic lupus erythematous with recurrent Guillain -Barré-like syndrome treated with intravenous immunoglobulins

Guillain-Barr� syndrome accompanied by central nervous system lupus in a patient with juvenile rheumatoid arthritis

The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes

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