Acute Polyneuritis After Nitrofurantoin Therapy

Ellis, F.R.

doi:10.1016/s0140-6736(62)90898-x

The Lancet

1962

DOI: 10.1016/s0140-6736(62)90898-x

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Acute Polyneuritis After Nitrofurantoin Therapy

F.R. Ellis¹

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1963

1991

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Cited by 34 publications

(2 citation statements)

References 6 publications

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“…(1977) Rose et al (1980);Saunders et al (1978);Wasserman et al (1980) Collins (1960;Ellis (1962); Klinghardt (1967); Lhermitte et al (1963); Loughridge (1962); Olivarius (1956); Toole et al (1968) Boone & Woodhall (1964) Layzer et al (1978) Laubenthal & Raffauf (1962) Bousser et al (1976); Fraser et al (1977); Lhermitte et al (1976); Pollet et al (1977); Sebille (1978) Birket-Smith & Krogh (1971); Lovelace & Horowitz (1968) Hadley & Herr (1979) Creaven & Mihich (1977); Weiss et al (1974) Berger & Schaumburg (1977) Rose et al (1980);Saunders et al (1978);Wasserman et al (1980) Collins (1960;Ellis (1962); Klinghardt (1967); Lhermitte et al (1963); Loughridge (1962); Olivarius (1956); Toole et al (1968) Boone & Woodhall (1964) Layzer et al (1978) Laubenthal & Raffauf (1962) Bousser et al (1976); Fraser et al (1977); Lhermitte et al (1976); Pollet et al (1977); Sebille (1978) Birket-Smith & Krogh (1971); Lovelace & Horowitz (1968) Hadley & Herr (1979) Creaven & Mihich (1977); Weiss et al (1974) Berger & Schaumburg…”

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Prevention and Management of Drug-Induced Peripheral Neuropathy

Olesen

Jensen

1991

Drug Safety

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When symptoms of peripheral neuropathy appear, the possibility that they have been induced by drugs should be considered. A large number of drugs of all kinds, several of which are considered indispensable, have been implicated in peripheral neuropathy. A list of some of these drugs is provided. Neuropathy is a universal and dose-limiting factor during treatment with vinca alkaloids, but is otherwise a rare complication of drug therapy. Drug-induced peripheral neuropathy is almost always due to a dose-dependent primary axonal degeneration caused either by toxic reactions or by metabolic changes in neurons or their surroundings. The use of drugs should be restricted, especially in patients with a risk for development of neuropathy or with already existing neuropathy, e.g. patients with hepatic or renal failure, diabetes mellitus, or malnutrition. Patients should be given vitamins, prophylactically or therapeutically, which will sometimes allow a treatment to be continued. In other cases of drug-induced neuropathy the drug should be stopped. Reversal depends on the severity of the neuropathy, intensity and duration of the treatment and existence of causative cofactors, but generally the prognosis is good. While waiting for recovery physiotherapy is of importance, and when paraesthesia and pain are troublesome the patient should be treated with carbamazepine, imipramine or lidocaine (lignocaine).

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Prevention and Management of Drug-Induced Peripheral Neuropathy

Olesen

Jensen

1991

Drug Safety

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“…A rather similar situation exists for another drug neuropathy, namely, nitrofurantoin. Neuropathy is rare except in patients with renal failure (Ellis 1962) and it has been demonstrated that impaired excretion in these people results in high blood levels of the drug (Loughridge 1962). Similar factors almost certainly exist in making some people more liable to industrial poisoning but at present little is known about these.…”

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Toxic Chemicals and Peripheral Neuropathy

Fullerton

1969

Proceedings of the Royal Society of Medicine

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Toxic Chemicals and Peripheral Neuropathy: Clinical and Epidemiological Features A large number of substances are known to produce peripheral neuropathy but only those substances which are, or have been, a hazard in industry will be considered here. All the druginduced neuropathies will be excluded except in so far as they illustrate some general principles. Although there are many known toxic substances, it is easy to exaggerate their clinical importance for it must be remembered that in a

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Nitrofurantoin Unmasking Peripheral Neuropathy in a Type 2 Diabetic Patient

White¹

1984

Arch Intern Med

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Acute Polyneuritis After Nitrofurantoin Therapy

Cited by 34 publications

References 6 publications

Prevention and Management of Drug-Induced Peripheral Neuropathy

Prevention and Management of Drug-Induced Peripheral Neuropathy

Toxic Chemicals and Peripheral Neuropathy

Nitrofurantoin Unmasking Peripheral Neuropathy in a Type 2 Diabetic Patient

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