2003
DOI: 10.1081/clt-120023760
|View full text |Cite
|
Sign up to set email alerts
|

Acute Poisonings withBreynia officinalis—An Outbreak of Hepatotoxicity

Abstract: The consumption of a soup containing B. officinalis Hemsley resulted in dose-related toxic effects. Clinical toxicity consisted primarily of gastrointestinal symptoms and signs and hepatotoxicity. Hepatocellular liver injury rather than cholestatic liver injury was observed. Marked jaundice did not develop.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
25
0

Year Published

2006
2006
2016
2016

Publication Types

Select...
4
2
1

Relationship

0
7

Authors

Journals

citations
Cited by 39 publications
(26 citation statements)
references
References 10 publications
1
25
0
Order By: Relevance
“…The aqueous whole plant extract did not affect the haematograms of the rats in a manner that would suggest adverse effects on their bone marrow, which is a source of recticulocytes. Some herbal remedies equally have hepato and nephro toxic effects [10,3]. Damage to these organs often results in the elevation of clinical chemistry parameters such as serum enzymes and analytes; some serum enzymes include aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and some analytes include total and conjugated bilirubin, urea, and creatinine [1,3,7,14].…”
Section: Discussionmentioning
confidence: 99%
“…The aqueous whole plant extract did not affect the haematograms of the rats in a manner that would suggest adverse effects on their bone marrow, which is a source of recticulocytes. Some herbal remedies equally have hepato and nephro toxic effects [10,3]. Damage to these organs often results in the elevation of clinical chemistry parameters such as serum enzymes and analytes; some serum enzymes include aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and some analytes include total and conjugated bilirubin, urea, and creatinine [1,3,7,14].…”
Section: Discussionmentioning
confidence: 99%
“…Phyllanthus niruri is widely used all over Asia for the treatment of jaundice and other hepatic disorders (Syamasundar et al, 1985;Unander et al, 1995;Lin et al, 2003). Venkateswaran et al (1987) reported that P. niruri inhibited the replication of woodchuck hepatitis virus in vivo and decreased its pathological effect on woodchuck liver.…”
Section: Introductionmentioning
confidence: 99%
“…They can cause the sinusoidal obstruction syndrome (veno-occlusive disease of the liver), 184 with clinical features that can occur. Plants that have been reported to cause acute liver damage include Breynia officinalis, 164 Callilepis laureola (ox-eye daisy), 165 Camellia sinensis (green tea), 166 Chelidonium majus (celandine), 167 Cimicifuga racemosa (black cohosh; Figure 76.21), 168,169 Larrea tridentata (chaparral), 170 Piper methysticum (kava; Figure 76.20; see below under Psychotropic drugs), Polygonum multiflorum, 171 Symphytum officinale (comfrey; see below under Sinusoidal obstruction syndrome) 172,173 and Teu crium spp. 174,175 Of these, black cohosh, chaparral, comfrey, and kava are the most common culprits.…”
Section: Impaired Platelet Aggregationmentioning
confidence: 99%