Acute poisonings in Croatia: differences in epidemiology, associated comorbidities and final outcomes – a single-centre 15-year follow-up

Klobučar, Iva; Potočnjak, Ines; Dumančìć, Jelena; Stemberger, Karlo; Čupić, Miriam; Kokotović, Tomislav; Kucijan, Zdravka; Degoricija, Vesna

doi:10.1080/15563650.2018.1506129

Cited by 6 publications

(6 citation statements)

References 11 publications

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“…Subgroup analysis revealed a difference in the alcohol and recreational substance toxicity rates of both genders. In general, reports show that women consume less alcohol than men, which is similar to our findings [ 27 – 30 ]. On the other hand, Peltier et al reported that this trend has been changing and the number of women who consume alcohol frequently in the USA is increasing rapidly [ 28 ].…”

Section: Discussionsupporting

confidence: 92%

“…In the USA, 2,710,042 cases were registered to the National Poison Data System in 2016, and results indicate an equal gender distribution in poisoning cases, which is similar to our findings [ 4 ]. However, in Ethiopia, female predominance [ 1 ], and, in Croatia, male predominance were reported [ 27 ]. Because of the high variability in the sample sizes, patient demographics and regions of the studies reported from Turkey, we are unable to form a hypothesis on gender distributions in acute intoxications.…”

Section: Discussionmentioning

confidence: 99%

“…Another study from a rural community in Turkey reported the suicide attempt rate as 68.6% among intoxications [ 33 ]. Suicide attempt rate was 91.1% in a study from Morocco [ 34 ], and lower in a declining trend in records from Croatia (46, 22, and 17%, respectively, in 2001, 2010 and 2015) [ 27 ]. Our study results also suggest a declining trend in the suicide attempt rate, considering the higher rates reported in the previous studies [ 32 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

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An Analysis of 1344 Consecutive Acute Intoxication Cases Admitted to an Academic Emergency Medicine Department in Turkey

Saçak

Akoğlu

Onur

et al. 2020

North Clin Istanbul

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OBJECTIVE: One of the major causes of emergency department (ED) visits is acute poisoning. Acute intoxications occur soon after either single or multiple exposures to toxic substances, and they started to be a more serious problem in developing countries. The objective of this study was to investigate the local patterns of acute intoxications, as well as clinical and sociodemographic characteristics of patients with acute poisoning, admitted to our hospital’s ED. METHODS: This single-center, retrospective study was conducted using medical records of consecutive patients admitted to the ED between January 2016 and December 2017. RESULTS: A total of 1344 patients were included in the statistical analysis. Of these, 673 (50.1%) were female. Mean (±SD) age was 32.2 (±12.0), ranging between 17 and 84 years. The highest number of poisoning cases was observed in summer, especially in July (10.0%) and August (11.8%), whereas lowest number of admissions related to poisoning occurred during winter in November (5.1%) and December (5.2%). Among admitted cases, many were suicide attempts (55.7%) followed by non-intentional (accidental) ingestion of non-pharmaceutical (n=553, 41.2%) and pharmaceutical agents (n=42, 3.1%). Single agents were the most common cause of acute intoxications (63.2%) rather than multidrug intoxications. Most frequently observed causes of poisonings were recreational substances (30.0%) and agents exposed by inhalation (13.2%). INR, lactate, and pH levels at admission were significant predictors of 7-day mortality without a significant paired difference between each other. The AUCs for each were 0.89 (SE 0.04; p<0.0001), 0.84 (SE 0.10; p=0.0007), and 0.79 (SE 0.11; p=0.0102), respectively. CONCLUSION: We conclude that recreational substances and medicinal drug intoxications were the leading cause of acute poisonings in our region, occurring mostly during the summer.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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An Analysis of 1344 Consecutive Acute Intoxication Cases Admitted to an Academic Emergency Medicine Department in Turkey

Saçak

Akoğlu

Onur

et al. 2020

North Clin Istanbul

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“…Acute drug poisonings lead to a significant number of hospitalizations in European countries. [1][2][3] Involved drugs may vary from time to time and between countries. In a Danish report based on data from the Danish Poison Information Center collected in 2007-2009, 4 a third of all calls concerned pharmaceuticals with paracetamol as the most commonly involved individual drug.…”

mentioning

confidence: 99%

Acute drug poisonings leading to hospitalization

Andersen

Nielsen

Møller

et al. 2021

Basic Clin Pharma Tox

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Knowledge about current trends and epidemiology in poisonings is important to maintain quality in diagnostics, treatment and prevention. We performed a cross-sectional study of all cases (n = 261) admitted with drug poisoning to Aalborg University Hospital during 1 year in 2017-2018. Median age was 30 (22-49) years, and 58% were female. Fifty percent were suicide attempts. In most cases, involved drugs were identified by history taking; blood analysis barely revealed any additional paracetamol and salicylicate poisonings. Drugs prescribed to the patient or available over the counter were involved in nearly two thirds of cases. Weak analgesics dominated by paracetamol (n = 91, 35%) was the most frequently involved group of drugs followed by opioids and benzodiazepines. Gender differences were observed with respect to involvement of weak analgesics and central stimulants. A higher prevalence of unidentified involved drugs was observed in 26 cases (10%) in which the length of admission exceeded 2 days and/or intensive care was needed. No deaths, cardiac arrhythmias or physical complications occurred. Thus, current handling of the acute poisoning seems effective in most cases. However, a more tailored use of blood analyses including a toxicological screen in selected cases may represent an opportunity for improvement.

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“…Для этого даже был предложен новый термин «токсикоэпидемиология» [2;3]. Вместе с тем, структура отравлений в различных регионах мира, а также в пределах одного географического региона и даже внутри отдельных регионов одной страны крайне неоднородна и подвержена значительным динамическим изменениям [4][5][6][7][8][9][10][11].В связи с этим, для разработки комплексной программы в области химической безопасности населения необходимы периодические компаративные исследования в области токсико-эпидемиологии.…”

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Бремя От Острых Отравлений В Городах Тбилиси И Баку

Кобидзе¹,

Эфендиев²,

Kereselidze³

et al. 2021

Journal of Clinic Sciences

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Острые отравления химической этиологии являются одной из значимых глобальных проблем мирового общественного здравоохранения. Согласно данным ВОЗ только непреднамеренные отравления привели за год к утрате более чем 10,7 млн. лет здоровой жизни в результате инвалидности (показатель DALY). При этом 84% смертности от острых отравлений пришлось на страны с низким и средним доходом (к которым относится в том числе и Грузия и Азербайджан). Еще около миллиона человек ежегодно умирают в результате самоубийств, и значительное число этих смертельных случаев обусловлено приемом химическими веществ. Только от преднамеренных отравлений пестицидами, по оценкам ВОЗ, в год умирает 370.000 человек в год.

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Acute poisonings in Croatia: differences in epidemiology, associated comorbidities and final outcomes – a single-centre 15-year follow-up

Cited by 6 publications

References 11 publications

An Analysis of 1344 Consecutive Acute Intoxication Cases Admitted to an Academic Emergency Medicine Department in Turkey

An Analysis of 1344 Consecutive Acute Intoxication Cases Admitted to an Academic Emergency Medicine Department in Turkey

Acute drug poisonings leading to hospitalization

Бремя От Острых Отравлений В Городах Тбилиси И Баку

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