Acute Pneumonitis After Subcutaneous Injections of Silicone for Augmentation Mammaplasty

Lai, Young-Fa; Chao, Tung‐Ying; Wong, Sui-Liong

doi:10.1378/chest.106.4.1152

Cited by 20 publications

(7 citation statements)

References 9 publications

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“…The phenomenon is acute with symptoms presenting within 72 hours after injection in most cases, and the risk appears to increase with higher doses of silicone. The pathologic findings on lung biopsy include alveolar hemorrhage [10–12], silicone deposits within the alveoli [13], and inclusions within alveolar macrophages [7, 14, 15]. The biopsy of our patient revealed silicone infiltration with subsequent spillage into alveolar spaces.…”

Section: Discussionmentioning

confidence: 85%

Respiratory Disease following Illicit Injection of Silicone: A Case Report

Essenmacher

Astani²

2013

Case Reports in Medicine

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Unregulated, pseudomedical procedures risk serious sequelae even when otherwise safe compounds are used. Silicone is commonly used legally in cosmetic procedures owing to its durability, resistance to heat and aging, and low immunogenicity. However, inappropriate or illegal silicone injection can pose severe local and systemic complications including serious pulmonary compromise. We describe the case of a 30-year-old female who presented with hemoptysis and progressive shortness of breath following illicit silicone injections to the gluteal fat and was found to have new, diffuse, bilateral, ground-glass opacities on contrast-enhanced pulmonary computed tomography. Transbronchial biopsy elucidated that this was a lipoid pneumonia-type injury secondary to silicone infiltration.

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Section: Discussionmentioning

confidence: 85%

Respiratory Disease following Illicit Injection of Silicone: A Case Report

Essenmacher

Astani²

2013

Case Reports in Medicine

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“…[1]. Pulmonary involvement associated with silicone injections have rarely been reported in the literature [2, 3, 4, 5]. …”

Section: Discussionmentioning

confidence: 99%

“…However, many adverse reactions after injection of silicone in human beings have been reported including silicone mastitis, granulomatous hepatitis, lymphadenopathy, liver granuloma formation, splenomegaly (causing pancytopenia), and acute febrile systemic reaction [1]. Pulmonary involvement has also been mentioned in the literature [2, 3, 4, 5]. Most of these cases were due to pulmonary embolism, acute respiratory distress syndrome, and acute and latent pneumonitis resulting from subcutaneous injection of silicone for augmentation mammoplasty either in women or in transsexual men.…”

Section: Introductionmentioning

confidence: 99%

A Case of Acute Pneumonitis Induced by Injection of Silicone for Colpoplasty

et al. 2003

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Silicone fluid (polymethylsiloxane) is a liquid polymer that had been widely used in breast augmentation and other cosmetic procedures. However, many adverse reactions after silicone injections into human beings have been reported including adverse pulmonary sequelae. We report a case of a 46-year-old woman who suffered from acute pneumonitis that was induced by illicit injection of silicone into the vaginal wall for colpoplasty. The pulmonary involvement was documented by transbronchial lung biopsy and bronchoalveolar lavage where examination with the electron microscope disclosed the presence of large quantities of pleomorphic cytoplasmic inclusions in alveolar macrophages. Clinicians should be aware of this unusual complication of injection of silicone.

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“…King (13,14) and the mutations are found in the adult cases (13,14). Thus (15) and interstitial pneumonia (16). Tattooing can also arouse a foreign body reaction.…”

Section: Case Reportmentioning

confidence: 99%