Acute phase responses following minimal access and conventional thoracic surgery

Craig, Stewart R; Leaver, H.A.; Yap, Peng Lee; Pugh, G.C.; Walker, William S.

doi:10.1016/s1010-7940(01)00841-7

Cited by 246 publications

(165 citation statements)

References 19 publications

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“…VATS or thoracotomy. Previous studies [26][27][28] comparing serum IL-6 levels in VATS with those in conventional thoracotomy demonstrated that the serum IL-6 levels were significantly lower in VATS than in conventional thoracotomy. Our results for all patients or for patients with confirmed pathological stage I A + I B were consistent with those in previously published reports.…”

Section: Discussionmentioning

confidence: 98%

Does Postoperative Serum Interleukin-6 Influence Early Recurrence after Curative Pulmonary Resection of Lung Cancer?

Kita

Shiraishi

Watanabe

et al. 2011

ATCS

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after the date of enrollment of the last patient, we investigated survival status of each patient and identified a group with recurrence. Results: Among 107 patients, 29 patients developed recurrence with a mean follow-up of 18.1 months (range 14 to 21). P-stage was significantly more advanced in the recurrence group than in the non-recurrence group (p = 0.005). Serum IL-6 levels on POD 1 were significantly higher in the recurrence group than in the non-recurrence group (p = 0.007). In Cox's proportional hazards regression, P-stage and serum IL-6 levels on POD 1 were significant independent predicting factors for postoperative early recurrence (p = 0.006, p = 0.003). Conclusions: The higher the serum IL-6 levels on POD 1, the higher the risk of early postoperative recurrence, even when curative pulmonary resection can be accomplished in lung cancer patients.

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Section: Discussionmentioning

confidence: 98%

Does Postoperative Serum Interleukin-6 Influence Early Recurrence after Curative Pulmonary Resection of Lung Cancer?

Kita

Shiraishi

Watanabe

et al. 2011

ATCS

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“…The minimal invasiveness of VATS lobectomy may reduce the immunosuppressive cytokine effect (36). Craig et al (37) demonstrated that VATS pulmonary lobectomy is associated with reduced peri-operative changes in acute phase responses. This finding may have implications for peri-operative tumor immuno-surveillance in lung cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes

Liu

2012

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to evaluate the evidence comparing video-assisted thoracoscopic surgery (VATS) and open lobectomy for the treatment of stage I lung cancer using meta-analytical techniques. A literature search was undertaken until July 2011 to identify comparative studies evaluating survival rates, recurrence rates and complications. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated with either the fixed-or random-effects model. These studies included a total of 1, IntroductionLung cancer is the most common malignant tumor in the world. With the improvement in diagnostic technology, more and more stage I lung cancer is identified. Video-assisted thoracoscopic surgery (VATS) was first reported by Levi et al in 1990 (1). The inital clinical reports on video-assisted thoracoscopic surgery lobe ctomy, published from 1993 onward, were either preliminary or involved a small number of patients, which indicated the feasibility and safety of VATS lobectomy (2-6). Since then, VATS has become an attractive surgical procedure for benign diseases, due to its low invasiveness (7,8). As the experience with VATS for benign diseases increased, VATS was gradually adopted for the treatment of lung cancer. Thereafter, VATS lobectomy for elderly patients and series involving a larger number of patients were reported (9-14). VATS lobectomy is now accepted, if not universally, at least as an alternative surgical option for early-stage lung cancer.The advantages of VATS lobectomy, which include less pain and better pulmonary function in the early postoperative period, have been previously reported. However, there are various controversies regarding the prognosis of VATS vs. open lobectomy for stage I lung cancer. Immune system function in the early postoperative period was found to be better preserved in patients who underwent VATS lobectomy. Curability after VATS lobectomy was also reported to be similar to the generally accepted curability rate after open lobectomy. Several investigators reported that the survival rate after VATS lobectomy was similar to that after open lobectomy. Sawada et al (15), Sugiura et al (16), Tashima et al (17) and Flores et al (18) reported that there was no statistically significant difference in survival between the VATS and open lobectomy in early-stage lung cancer. However, this meta-analysis showed that VATS had significantly better survival rates in terms of overall survival at 5 years. Materials and methodsStudy selection. Electronic searches were performed of the MEDLINE, Cochrane Controlled Trial Register (CENTRAL) and EMBASE databases until July 2011. The following Mesh search headings were used: (VATS, video-assisted thoracoscopic or video-assisted thoracoscopic surgery), (open or conventional or standard lobectomy), (lung cancer or lung carcinoma), (randomized controlled trials) and (comparative study) in English (Fig. 1).Data extraction and quality assessment. Data were extracted by three independent observers using standardized forms. The rec...

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“…Two other studies [79,80] reported information on outcomes of interest and found no substantial differences between the groups, except for fewer air leaks found in the study by Kirby et al [78].…”

Section: Vats Major Pulmonary Resectionsmentioning

confidence: 90%

“…Nevertheless, these presumed advantages over open surgery have neither been clearly assessed nor demonstrated in a systematic review of the evidence from randomized trials, rendering it impossible to make recommendations for best practice or to provide guidance for wider application of this minimally invasive technique [77][78][79][80].…”

Section: Vats Major Pulmonary Resectionsmentioning

confidence: 99%

“…Other fields of comparison are: (a) the duration of the surgical procedure, which proved to be equivalent for experienced surgeons [77][78][79][80]85] with a lower mean blood loss in favor of the VATS procedure [86,87,81]; (b) the length of the postoperative course, which, according to the recent review by McKenna et al [84], appears to be the same or shorter for the endoscopic approach; and (c) the overall hospital costs, as measured by anesthesia charges, laboratory charges, and hospital charges, which are also reported to be lower with the VATS approach [88].…”

Section: Vats Major Pulmonary Resectionsmentioning

confidence: 99%

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Indications and Developments of Video-Assisted Thoracic Surgery in the Treatment of Lung Cancer

Solli

Spaggiari

2007

The Oncologist

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After completing this course, the reader will be able to:1. Discuss the role of thoracoscopy in the evaluation of pulmonary nodules and pleural effusion.2. Describe the role of thoracoscopy in the staging of lung cancer.3. Discuss the role of thoracoscopy in surgical resection of early-stage lung cancer.Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com CME CME ABSTRACTThe term video-assisted thoracic surgery (VATS) is used to describe a modern minimally invasive surgical technique that nowadays represents a valid alternative to open procedures (i.e., thoracotomy) for many chest diseases. The VATS approach is presently used in many intrathoracic disorders, but while well established in benign chest disease, its role continues to evolve regarding the management of lung cancer. It is currently considered for the evaluation and treatment of suspected (or known) pleural effusion and in the diagnosis of indeterminate pulmonary nodules, and it has a complementary role to standard cervical mediastinoscopy in the invasive staging of mediastinal lymph nodes. It has also become an accepted approach for resection of peripheral early-stage lung cancer (stage I) in many centers worldwide and considerable experience has been accumulated in respect to this field, but absolute indications have yet to be firmly defined. This paper reviews indications and current data regarding minimally invasive approaches for the staging and treatment of lung cancer.

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Acute phase responses following minimal access and conventional thoracic surgery

Abstract: VATS pulmonary lobectomy is associated with reduced peri-operative changes in acute phase responses. This finding may have implications for peri-operative tumour immuno-surveillance in lung cancer patients.

Cited by 246 publications

References 19 publications

Does Postoperative Serum Interleukin-6 Influence Early Recurrence after Curative Pulmonary Resection of Lung Cancer?

Does Postoperative Serum Interleukin-6 Influence Early Recurrence after Curative Pulmonary Resection of Lung Cancer?

Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes

Indications and Developments of Video-Assisted Thoracic Surgery in the Treatment of Lung Cancer

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