Acute phase response in calves following infection with Pasteurella haemolytica, Ostertagia ostertagi and endotoxin administration

Conner, Joe; Eckersall, P.D.; Wiseman, A; Bain, R.K.; Douglas, T. A.

doi:10.1016/s0034-5288(18)31206-2

Cited by 71 publications

(68 citation statements)

References 8 publications

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“…Other authors have also found haptoglobin and serum amyloid A to be useful prognostic indicators in diseased cattle (10,13,14,15,20). Proteins such as fibrinogen, alpha-1-antitrypsin, and acid-soluble glycoproteins responded moderately in this and other infection models (8,10,23).…”

Section: Discussionmentioning

confidence: 65%

ITIH4 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 4) Is a New Acute-Phase Protein Isolated from Cattle during Experimental Infection

et al. 2004

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We have isolated from calf serum a protein with an apparent M r of 120,000. The protein was detected by using antibodies against major acute-phase protein in pigs with acute inflammation. The amino acid sequence of an internal fragment revealed that this protein is the bovine counterpart of ITIH4, the heavy chain 4 of the inter-alpha-trypsin inhibitor family. The response of this protein in the sera was determined for animals during experimental bacterial and viral infections. In the bacterial model, animals were inoculated with a mixture of Actinomyces pyogenes, Fusobacterium necrophorum, and Peptostreptococcus indolicus to induce an acute-phase reaction. All animals developed moderate to severe clinical mastitis and exhibited remarkable increases in ITIH4 concentration in serum (from 3 to 12 times the initial values, peaking at 48 to 72 h after infection) that correlated with the severity of the disease. Animals with experimental infections with bovine respiratory syncytial virus (BRSV) also showed increases in ITIH4 concentration (from two-to fivefold), which peaked at around 7 to 8 days after inoculation. Generally, no response was seen after a second infection of the same animals with the virus. Because of the significant induction of the protein in the animals in the mastitis and BRSV infection models, we can conclude that ITIH4 is a new positive acute-phase protein in cattle.The acute-phase response occurs in animals as a consequence of infection, inflammation, or trauma. It is a nonspecific response mediated by inflammation-related cytokines (mainly by interleukin-6 [IL-6], IL-1, and tumor necrosis factor alpha) and is characterized by several systemic reactions, including fever, catabolism of muscle protein, alterations in sleep and appetite patterns, and changes in the concentrations of a group of serum proteins called acute-phase proteins (APP) (3,22,27,40).APP have been studied extensively in humans and in many animal species, mostly rats (38), though the panel of these proteins is probably not complete. The APP response differs among species. For domestic animals, the studies on APP are relatively recent (reviewed in reference 18). For cattle, several APP, including serum amyloid A, haptoglobin, alpha-1-acid glycoprotein, and alpha-1-proteinase inhibitor (alpha-1-antitrypsin), have been shown to increase in different inflammatory processes, in both in vivo (9,14,18,20,23,25,32) and in vitro models (2, 31). The course of infection in human patients is monitored by the determination of APP in blood samples (43), and a similar clinical use has been proposed for veterinary medicine (15,18,26) as well as for monitoring the health status of animals during farm production and at slaughter (42).In previous works from our laboratory, a new 120-kDa plasma glycoprotein, designated major acute-phase protein or pig MAP, was described as an APP occurring in pigs with turpentine-induced inflammation (16,29). This protein, which is also called porcine inter-alpha-trypsin inhibitor human-related protein (pig IHRP) (...

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Section: Discussionmentioning

confidence: 65%

ITIH4 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 4) Is a New Acute-Phase Protein Isolated from Cattle during Experimental Infection

et al. 2004

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“…Conner et al (1989) showed that intra-tracheal aerosol inoculation with Mannheimia haemolytica in calves raised the levels of haptoglobin, α 1 -antitrypsin, and seromucoid. Horadagoda and Eckersall (1994) also evaluated calves intra-tracheally infected with M. haemolytica.…”

Section: Acute Phase Proteins In Calf Diseasesmentioning

confidence: 99%

Acute phase proteins and their use in the diagnosis of diseases in ruminants: a review

Tóthová¹,

Nagy²,

Kováč³

2014

Vet. Med.

162

160

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ABSTRACT:The acute phase response is a complex systemic early-defence system of reactions activated by trauma, infection, tissue damage, inflammation, stress or neoplasia. One of the most important elements of this response is the increased hepatic synthesis of some plasma proteins, collectively known as acute phase proteins. The discovery of these new biomarkers has allowed the clinical monitoring of different diseases; therefore, their clinical application has been studied widely in human medicine in order to improve the diagnosis, evaluation, treatment, prognosis and therapeutics of many diseases. Although a wide range of studies have been carried out to determine the usefulness of acute phase proteins in several diseases also in animals, they are still relatively under-utilised in veterinary medicine, predominantly in farm animals. The acute phase response and clinical application of acute phase proteins in ruminants are reviewed in this article, including their diagnostic use in clinical practice and application in the monitoring of treatment, which is one of the most promising practical uses of these proteins.

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“…Para as demais proteínas de fase aguda avaliadas (Tabela 1), verificou-se que os seus valores medianos oscilaram conforme a seguir discriminado: ceruloplasmina entre 31,3 e 56,7 mg/dl; transferrina entre 523,4 e 685 mg/dl; e, haptoglobina entre 8,28 e 22,5 mg/dl. A concentração sérica de glicoproteína ácida altera-se significativamente após um processo inflamatório (CONNER et al, 1989), sendo relatado um significativo aumento nos seus valores em quadros A concentração sérica de glicoproteína ácida altera-se significativamente após um processo inflamatório (CONNER et al, 1989), sendo relatado um significativo aumento nos seus valores em quadros de broncopneumonia induzidos em bezerros inoculados com Mannheimia haemolytica (FAGLIARI et al, 2003) e de mastite em novilhas gestantes (HIRVONEN; PYORALA; JOUSIMIES-SOMER, 1996). À semelhança do que foi observado na presente pesquisa, relatou-se o aumento da glicoproteína ácida no puerpério fisiológico de bovinos, sendo que nesta espécie animal o retorno aos patamares de normalidade ocorria tardiamente, somente a partir do 21º dia pós-parto (SHELDON et al, 2001).…”

Section: Resultsunclassified

Influência do puerpério sobre o proteinograma sérico de caprinos da raça Saanen obtido por eletroforese em gel de poliacrilamida

et al. 2008

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Recebido para publicação 28/02/08 Aprovado em 16/02/09 AbstractAiming to evaluate the puerperal influence on the proteinogram of Saanen goats, 108 samples of blood serum from 12 goats were collected, and the results were presented at nine times: just after parturition, 1, 3, 5, 7, 10, 15, 21 and 30 days after parturition. Total amount of serum proteins were determined by the biuret technique, and the sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) was used to the protein fractionation. In this last method, 17 protein bands were observed, from which molecular weights varied between 25 KDa and 275 KDa. In addition, it was possible to identify the following protein fractions: immunoglobulin A (180 KDa), ceruloplasmin (115 KDa), transferrin

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Acute phase response in calves following infection with Pasteurella haemolytica, Ostertagia ostertagi and endotoxin administration

Cited by 71 publications

References 8 publications

ITIH4 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 4) Is a New Acute-Phase Protein Isolated from Cattle during Experimental Infection

ITIH4 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 4) Is a New Acute-Phase Protein Isolated from Cattle during Experimental Infection

Acute phase proteins and their use in the diagnosis of diseases in ruminants: a review

Influência do puerpério sobre o proteinograma sérico de caprinos da raça Saanen obtido por eletroforese em gel de poliacrilamida

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