Acute Phase Reactants in Allergic Airway Disease

Abstract

Acute phase reactants have been implicated for their involvement as proinflammatory molecules in various inflammatory diseases. However, little is known regarding their role in the allergic airway disease. The aim of the present study was to examine the blood concentrations of three acute-phase proteins, namely C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen in patients with allergic rhinitis and asthma. Three study groups include: non-smoker allergic rhinitis (n = 50), non-smoker asthma (n = 20), and non-allergic, non-smoker healthy control subjects (n = 20). Patients who have had recent upper or lower respiratory tract infection and trauma, any rheumatological illnesses, malignancy or obesity were excluded. Blood samples were obtained from all the patients and control subjects and were analyzed for serum CRP, SAA and plasma fibrinogen. The mean CRP and fibrinogen values in the rhinitis and asthma groups were not significantly different when compared to the control group. However, the mean SAA levels of both groups were found to be significantly higher than those of the control group (p = 0.002 for rhinitis, p = 0.02 for asthma). There was no significant correlation between the FEV 1 values and the levels of the serum markers. This study demonstrates that acute phase reactant SAA rises in patients with allergic rhinitis and patients with asthma. We therefore suggest that SAA may have a role in the inflammatory airway disease.acute phase proteins; C-reactive protein; Serum amyloid A; fibrinogen; allergic rhinitis; asthma; inflammation

Changes in High-Sensitivity C-Reactive Protein in Serum and Exhaled Breath Condensate after Intensive Exercise in Patients with Allergic Asthma

“…It has also been shown that in patients with asymptomatic asthma increased levels of amyloid A were present [24]. Taking these findings into account, it is very likely that systemic inflammation may exist in asthma.…”

Signal Relay by CC Chemokine Receptor 2 (CCR2) and Formylpeptide Receptor 2 (Fpr2) in the Recruitment of Monocyte-derived Dendritic Cells in Allergic Airway Inflammation

“…This dynamic regulation of chemoattractant receptors on myeloid cells including DCs represents an important host response during disease states (38). In the inflamed lung, recruited inflammatory DCs immediately encounter a variety of bacteria-and host-derived TLR agonists such as LPS, PGN, HMGB1, fragment of fibronectin, and hyaluronic acid oligosaccharides (31,39,40), which reduce CCR2 but increase Fpr2 expression and function, enabling the cells to reach small airways in response to the Fpr2 agonist CRAMP produced in the inflamed tissue (41)(42)(43)(44).…”

Airway Remodeling in Asthma and its Influence on Clinical Pathophysiology

“…Proliferation of epithelial cells and prominent goblet cell hyperplasia are characteristic histological findings in asthmatic airway, and these changes are thought to be originated from epithelial damage caused by eosinophils (Büyüköztürk et al 2004). To date, the study on experimental models with mice demonstrated that Th2 cytokines including interleukin (IL)-4, IL-9 and IL-13 play important roles in induction of goblet cell hyperplasia (Elias et al 1999).…”