Acute‐Phase Proteins in Wound Healing

Ah, Gordon

doi:10.1002/9780470719923.ch5

Cited by 10 publications

(1 citation statement)

References 42 publications

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“…6,30 As in arthritis, acute-phase proteins and chronic inflammatory events seem to be involved in wound healing. 31,32 We have also demonstrated that fastregenerative AIRmax SS mice are extremely susceptible to pristane-induced arthritis, showing the high levels of cytokines involved in chronic inflammation. 13 Further, the different abilities of AIRmax and AIRmin mice to induce an initial polymorphonuclear cell influx and to repair damaged tissue might both in part explain their different susceptibility to lung tumor development after urethane treatment.…”

Section: Discussion Of Findings and Relevant Literaturementioning

confidence: 92%

Acute Inflammation Loci Are Involved in Wound Healing in the Mouse Ear Punch Model

Canhamero¹,

Garcia²,

Franco³

2014

Advances in Wound Care

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Molecular biology techniques are being used to aid in determining the mechanisms responsible for tissue repair without scar formation. Wound healing is genetically determined, but there have been few studies that examine the genes responsible for tissue regeneration in mammals. Research using genetic mapping is extremely important for understanding the molecular mechanisms involved in the different phases of tissue regeneration. This process is complex, but an early inflammatory phase appears to influence lesion closure, and the present study demonstrates that acute inflammation loci influence tissue regeneration in mice in a positive manner. Mapping studies of quantitative trait loci (QTL) have been undertaken in recent years to examine candidate genes that participate in the regeneration phenotype. Our laboratory has identified inflammation modifier QTL for wound healing. Mouse lines selected for the maximum (AIRmax) or minimum (AIRmin) acute inflammatory reactivity (AIR) have been used to study not only the tissue repair but also the impact of the genetic control of inflammation on susceptibility to autoimmune, neoplasic, and infectious diseases. Murphy Roths Large and AIRmax mice are exclusive in their complete epimorphic regeneration, although middle-aged inbred mice may also be capable of healing. Inflammatory reactions have traditionally been described in the literature as negative factors in the process of skin injury closure. Inflammation is exacerbated due to the early release of mediators or the intense release of factors that cause cell proliferation after injury. The initial release of these factors as well as the clean-up of the lesion microenvironment are both crucial for following events. In addition, the activation and repression of some genes related to the regeneration phenotype may modulate lesion closure, demonstrating the significance of genetic studies to better understand the mechanisms involved in the initiation of wound repair processes. The pleiotropic effects of the QTL are important in the identification of the genes responsible for tissue repair processes, especially when combined with global gene expression research. Microarray analysis complements the biological information obtained in QTL mapping, making this tool essential for gene identification. This approach will allow the investigation of future targets for therapeutic wound healing treatments.

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Section: Discussion Of Findings and Relevant Literaturementioning

confidence: 92%

Acute Inflammation Loci Are Involved in Wound Healing in the Mouse Ear Punch Model

Canhamero¹,

Garcia²,

Franco³

2014

Advances in Wound Care

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Role of Endoplasmic Reticulum and Golgi Apparatus in the Biosynthesis of Plasma Glycoproteins

Molnár

1976

The Enzymes of Bioligical Membranes

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Slc11a1 (Nramp1) alleles interact with acute inflammation loci to modulate wound-healing traits in mice

et al. 2007

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Lines of mice were obtained by selective breeding for maximum (AIRmax) or minimum (AIRmin) acute inflammation. They present distinct neutrophil influx and show frequency disequilibrium of the solute carrier family 11a member 1 (Slc11a1) alleles. This gene is involved in ion transport at the endosomes within macrophages and neutrophils, interfering in their activation. Homozygous AIRmax and AIRmin sublines for the Slc11a1 gene were produced to examine the interaction of this gene with the acute inflammatory loci. The present work investigated wound-healing traits in AIRmax and AIRmin mice, in F(1) and F(2) intercrosses, and in Slc11a1 sublines. Two-millimeter ear punches were made in the mice and hole closure was measured during 40 days. AIRmax mice demonstrated significant tissue repair while AIRmin mice did not. Significant differences between the responses of male and female mice were also observed. Wound-healing traits demonstrated a correlation with neutrophil influx in F(2) populations. AIRmax( SS )showed higher ear-wound closure than AIRmax( RR ) mice, suggesting that the Slc11a1 S allele favored ear tissue repair. QTL analysis has detected two inflammatory loci modulating ear wound healing on chromosomes 1 and 14. These results suggest the involvement of the acute inflammation modifier QTL in the wound-healing phenotype.

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Acute‐Phase Proteins in Wound Healing

Cited by 10 publications

References 42 publications

Acute Inflammation Loci Are Involved in Wound Healing in the Mouse Ear Punch Model

Acute Inflammation Loci Are Involved in Wound Healing in the Mouse Ear Punch Model

Role of Endoplasmic Reticulum and Golgi Apparatus in the Biosynthesis of Plasma Glycoproteins

Slc11a1 (Nramp1) alleles interact with acute inflammation loci to modulate wound-healing traits in mice

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