Acute phase proteins in dogs naturally infected with the Giant Kidney Worm (<i>Dioctophyme renale</i>)

Schmidt, Elizabeth Moreira dos Santos; Kjelgaard‐Hansen, Mads; Thomas, Funmilola Clara; Tvarijonaviciute, Asta; Cerón, José J.; Eckersall, P.D.

doi:10.1111/vcp.12400

Cited by 6 publications

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“…These increases are related to the inflammatory response induced by pro-inflammatory cytokines interleukin-1, interleukin-6 and alpha tumor necrosis factor, which stimulate synthesis and release of APP by the liver (Gruys et al 2005, Eckersall 2008. In our study, these results could evidence an acute inflammatory response as the median concentrations of CRP and Hp were above the reference intervals for dogs (CRP <12µg/mL, Hp<3 g/L) (Eckersall et al 1999, Ceron et al 2005, from 24 hours after the surgical procedure, similarly to those described previously for acute phase proteins after surgical trauma in dogs (Conner et al 1988, Dabrowski et al 2007, Tvarijonaviciute et al 2011, Kjelgaard-Hansen et al 2013, Schmidt et al 2016.…”

Section: Discussionsupporting

confidence: 88%

“…CRP is the major acute phase protein in dogs and also a consistent marker of inflammation in this species, stimulated by the inflammatory response increasing up to 10-to 100-fold (Ceron et al 2005, Eckersall 2008. Haptoglobin is considered a moderate acute phase protein in dogs and has also been used as a nonspecific biomarker of inflammation, but there is an APP pattern that has been described in dogs with hyperadrenocorticism (McGrotty et al 2003, Caldin et al 2009 and in dogs infected by the giant kidney worm (Dioctophyme renale) (Schmidt et al 2016), with increased Hp concentration indicating a stress response due to increased endogenous cortisol concentration (Caldin et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…In order to improve the surgical procedure and monitoring of the postoperative period, it is necessary to identify markers that are useful to evaluate the intensity of the trauma caused by the procedure. Recent investigations have demonstrated changes in APP concentrations in dogs related to the extent and progression of diseases, as well as their the inflammatory response in infectious, parasitic, trauma, degenerative diseases and neoplastic diseases (Bayramli & Ulutas 2008, Koster et al 2009, Tecles et al 2009, Méndez et al 2014, Schmidt & Eckersall 2015, Hillström et al 2016, Schmidt et al 2016. However, although the acute phase response was investigated in dogs undergoing elective soft tissue surgeries (Serin & Ulutas 2010, Kjelgaard-Hansen et al 2013, Kum et al 2013, surgical correction of obstructive airway syndrome (Planellas et al 2015), nephrectomy (Schmidt et al 2016), and ovariohysterectomy as the treatment of pyometra (Dabrowski et al 2007(Dabrowski et al , 2009 few studies have evaluated the PFA concentrations and the acute phase response dynamics in dogs undergoing minimally invasive surgical procedures (Mathon et al 2011, Tvarijonaviciute et al 2011, Kjelgaard-Hansen et al 2013.…”

Section: Introductionmentioning

confidence: 99%

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Acute phase proteins in bitches subjected to conventional and minimally invasive ovariohysterectomy

et al. 2018

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The aim of this study was to evaluate and to compare the possible inflammatory changes by screening acute phase proteins concentrations in healthy bitches subjected to ovariohysterectomy. Minimally invasive and conventional (laparotomy) ovariohysterectomies were performed in 17 client-owned adult female mixed breed dogs. Nine animals were subjected to minimally invasive and eight animals to conventional ovariohysterectomy. Blood samples were taken before surgery, 24, 48 hours, and seven days postoperatively. Serum C-reactive concentration was determined by a commercial ELISA kit and serum haptoglobin concentration was measured via hemoglobin binding assay, both previously validated for use in dogs. As the data did not meet the normal distribution criteria, the nonparametric Kruskall-Wallis was performed to compare quantitative variables between groups. One-way ANOVA and the Friedman test were used for multiple comparisons between time points, with a P<0.05 considered significant. C-reactive protein concentration was significantly different (P<0.0001) at 24 hours postoperatively between groups. There was no significant difference in haptoglobin concentration between groups. C-reactive protein and haptoglobin concentrations were significantly different at 24 and 48 hours postoperatively for minimally invasive and conventional ovariohisterectomies. These findings provided an overview of the short-term inflammatory effects produced by minimally invasive and conventional ovariohysterectomies.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acute phase proteins in bitches subjected to conventional and minimally invasive ovariohysterectomy

et al. 2018

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“…Grant e Forrester (2008), afirmam que a hiperproteinemia nos exames pode ser um indício de dioctofimose. Durante a resposta aguda na dioctofimose canina, Schmidt et al (2016) observaram um aumento na concentração de haptoglobina (proteína da fase aguda de processos inflamatórios) o que pode ter contribuído na hiperproteinemia dos cães parasitados.…”

Section: Discussionunclassified

PARASITISMO POR Dioctophyme renale ENCONTRADO EM CÃES DE ABRIGOS DO MUNICÍPIO DE SÃO MATEUS DO SUL, ESTADO DO PARANÁ

Zanchett

Pedrassani

2020

AVS

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Dioctophyme renale é um nematódeo zoonótico que parasita os rins de carnívoros domésticos e silvestres no Brasil. Entre os cães têm maior prevalência em errantes, principalmente, por conta dos hábitos menos seletivos, tornando interessante o estudo com os mesmos. Animais que vivem em abrigos, geralmente apresentam histórico de viver em ambiente precário, acesso restrito à água limpa e alimento adequado e, em superpopulação, favorecendo a disseminação da dioctofimose. Por conta disso, este trabalho teve o objetivo de verificar a ocorrência do parasitismo por D. renale em cães de abrigos do município de São Mateus do Sul, estado do Paraná. Os animais foram transportados por uma Organização Não Governamental (ONG) até o Hospital Veterinário Escola para procedimento de ovariosalpingohisterectomia (OSH). Os resultados das análises hematológica, bioquímica e da urina foram comparados entre cães parasitados e não parasitados pelo teste t de Student e a idade foi avaliada pelo teste exato de Fisher (p≤ 0,05). Entre agosto e novembro de 2018, o abrigo encaminhou 38 fêmeas, sem raça definida para OSH e destas, três (7,89%) apresentaram ovos do parasito na urina. Um, dentre os três cães positivos para D. renale foi a óbito durante a cirurgia e na necropsia uma fêmea do parasito foi observada no rim esquerdo. A creatinina foi significativamente mais alta nos cães que apresentaram ovos do parasito na urina (p=0,015). Não foram observadas diferenças entre cães que apresentaram ou não ovos do parasita na urina em relação aos fatores: dosagem de ureia e de proteínas plasmáticas totais, hemograma, leucograma, análise física da urina, assim como idade (p>0,05). É possível concluir que em cães do município, principalmente, os de abrigos, os exames rotineiros de urinálise e dosagem de creatinina, mesmo naqueles aparentemente saudáveis, são importantes para um diagnóstico precoce de parasitismo por D. renale.

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“…When this article was published in the journal, there was an error in the third paragraph of the Results and in Table 1.…”

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confidence: 99%

Erratum

2017

Veterinary Clinical Pathol

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Acute phase proteins in dogs naturally infected with the Giant Kidney Worm (Dioctophyme renale)

Abstract: There is a particular acute phase response profile in dogs with kidney worm infection. Nephrectomy induced a short-term inflammatory process.

Cited by 6 publications

References 38 publications

Acute phase proteins in bitches subjected to conventional and minimally invasive ovariohysterectomy

Acute phase proteins in bitches subjected to conventional and minimally invasive ovariohysterectomy

PARASITISMO POR Dioctophyme renale ENCONTRADO EM CÃES DE ABRIGOS DO MUNICÍPIO DE SÃO MATEUS DO SUL, ESTADO DO PARANÁ

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