Acute phase proteins as prospective risk markers for arterial stiffness: The Malmö Diet and Cancer cohort

Abstract

Background and objectivesArterial stiffness plays a significant role in the development and progression of adverse cardiovascular events and all-cause mortality. This observational study aims to explore the relationship between six acute phase proteins namely, ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin, complement C3 and C-reactive protein (CRP), and carotid-femoral pulse wave velocity (c-f PWV) in a population-based cohort, and to also explore the effect of low-grade inflammation on the relationship between diabetes and c-f PWV.MethodThe study consisted of participants from the Malmö Diet and Cancer study with data from baseline examinations (1991–1994) and follow-up examinations (2007–2012). Arterial stiffness was measured at follow-up by determining c-f PWV. After excluding participants with missing data, the total study population included 2338 subjects. General linear models were used to assess the relationship between baseline acute phase proteins and c-f PWV.ResultsAfter adjusting for traditional risk factors the participants in the 4th quartile vs 1st quartile of alpha-1-antitrypsin (geometric mean: 10.32 m/s vs 10.04 m/s) (p<0.05), C3 (10.35 m/s vs 10.06 m/s) (p<0.05) and CRP (10.37 m/s vs 9.96 m/s) (p<0.001) showed significant association with c-f PWV. Diabetes at follow-up was also associated with high c-f PWV, however, this relationship was independent of low grade inflammation.ConclusionAlpha-1-antitrypsin, C3 and CRP are associated with arterial stiffness. The results indicate that low grade inflammation is associated with arterial stiffness in addition to established cardiovascular risk factors.

A GTPase-activating protein–binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells

“…At necropsy, no differences were exhibited between groups with respect to fasting hypercholesterolemia (LDLR Ϫ/Ϫ versus MAVS Ϫ/Ϫ ;LDLR Ϫ/Ϫ and 975 Ϯ 34 versus 1012 Ϯ 37 mg/dl; p ϭ NS), hypertriglyceridemia (296 Ϯ 25 versus 316 Ϯ 40 mg/dl; p ϭ NS), weight (34.0 Ϯ 2.1 versus 33.7 Ϯ 1.0 g; p ϭ NS), or diabetes in the homeostatic model assessment of insulin resistance (56) (HOMA-IR; 17 Ϯ 5 versus 16 Ϯ 7; p ϭ NS). MAVS deficiency did not globally reduce diet-induced increases in the inflammation associated with insulin resistance (57,58) as indicated by the circulating biomarker haptoglobin (7, 57) (supporting data S12). Atheroma lesion area, assessed by Mac2 staining at the level of the aortic sinus, was unaltered (p ϭ 0.88; supporting S13).…”

Diabetic Retinopathy: Changes in Levels of Orosomucoids in Patients Supplemented with Beta Glucan and Vitamin D

“…Literature shows that persistent increased levels of acute inflammation proteins can predict significant increase in weight in middle age population. This relation can lead to the assumption about possible subsequent connection with metabolic syndrome, cardiovascular diseases, diabetes and other health problems (Muhammad et al, 2017;Engstrom et al, 2003;Jensen and Whitehead, 1998). Association of elevated levels of ORM, haptoglobin and CRP with an elevated risk of DM development was already described (Duh et al, 2017;Muhammad et al, 2017).…”

“…Association of elevated levels of ORM, haptoglobin and CRP with an elevated risk of DM development was already described (Duh et al, 2017;Muhammad et al, 2017). This high risk of diabetes related to high levels of acute inflammatory protein can be accepted with one condition: additional possible mechanisms involved must be evaluated and described (Muhammad et al, 2017). High ORM levels on DM1 reflect endothelial dysfunction and subclinical atherosclerosis and can be considered as an early marker of renal injury (El-Beblawy et al, 2016).…”

“…This relation can lead to the assumption about possible subsequent connection with metabolic syndrome, cardiovascular diseases, diabetes and other health problems (Muhammad et al, 2017;Engstrom et al, 2003;Jensen and Whitehead, 1998). Association of elevated levels of ORM, haptoglobin and CRP with an elevated risk of DM development was already described (Duh et al, 2017;Muhammad et al, 2017). This high risk of diabetes related to high levels of acute inflammatory protein can be accepted with one condition: additional possible mechanisms involved must be evaluated and described (Muhammad et al, 2017).…”

“…Prevalence of Diabetes Mellitus (DM) shows steep incline, both in DM Type 1 (DM1) and less steeply in DM Type 2 (DM2) (Duh et al, 2017;Muhammad et al, 2017). Diabetic patients are endangered by various complications, influencing the quality of their life functions.…”