Acute-phase and 1-year follow-up results of a randomized controlled trial of CBT versus Befriending for first-episode psychosis: the ACE project

Abstract

There is some preliminary evidence that ACE promotes better early recovery in functioning and this finding needs to be replicated in other independent research centres with larger samples.

Early intervention in psychosis: concepts, evidence and future directions

“…Psychosocial treatments in early psychosis have been extensively studied, and there are positive findings pointing to the value of cognitive therapies in accelerating and maximizing symptomatic and functional recovery (81,82). Increasingly there has been attention to the fact that medications, while assisting in symptomatic recovery, do not, by themselves, contribute to a return to functioning.…”

Conventional and alternative preventive treatments in the first stages of schizophrenia

“…This model posits that dysfunctional interpretations of anomalous experiences contribute, against a background of pre-existing biopsychosocial vulnerability, to the emergence and maintenance of psychotic symptoms 37, 38 . Results from trials of CBT in the ARMS and early schizophrenia suggest that the therapy is moderately effective in reducing transitions to psychosis 39,40,41 , reducing relapse rates 42 , speeding recovery 43 , reducing subclinical and clinical positive symptom severity 39,40,44 and improving perceived quality of life 45 . However, durability of CBT in absence of continued treatment is unclear with reports of both durable effects in the ARMS 39 and lack thereof in FEP 42,44,45 .…”

“…Results from trials of CBT in the ARMS and early schizophrenia suggest that the therapy is moderately effective in reducing transitions to psychosis 39,40,41 , reducing relapse rates 42 , speeding recovery 43 , reducing subclinical and clinical positive symptom severity 39,40,44 and improving perceived quality of life 45 . However, durability of CBT in absence of continued treatment is unclear with reports of both durable effects in the ARMS 39 and lack thereof in FEP 42,44,45 . Lack of sustained effect of CBT may in part be due to the limited duration of treatment and more longitudinal trials with longer duration of CBT treatment are therefore needed 7,42 .…”

La thérapie cognitivo-comportementale des psychoses en début d'évolution: étude ouverte en milieu clinique

“…Cependant, la généralisation de ces résultats en milieux cliniques (c'est-à-dire, la validité externe) de la TCCp reste à explorer 5 . Parmi les études de TCCp publiées, 7 avaient pour échantillon des patients souffrant de psychoses débutantes [6][7][8][9][10][11][12] , l'intervention pendant cette « période critique » 13,14 étant particulièrement intéressante, compte tenu de la possibilité d'influencer favorablement l'évolution à long terme. Aucune de ces études n'a démontré une efficacité supérieure statistiquement significative de la TCCp par rapport à une condition contrôle.…”

“…Deuxièmement, l'intervention est parfois très brève. En effet, 4 études ont expérimenté un programme de TCCp d'une durée égale ou inférieure à 14 semaines 6,7,10,12 . Aussi, 4 études rapportent une participation moyenne moins de 12 heures de TCCp par patient 7,[10][11][12] .…”